Male Comprehensive Hormone Profile II

Male Comprehensive Hormone Profile II – 14-Marker Blood Spot Test (Hormones + Full Thyroid Panel)

Test ID: B-243M | At-Home Blood Spot Collection | Results in 3–5 Working Days | Designed for Men

The Male Comprehensive Hormone Profile II is our most advanced men’s hormone blood spot test, measuring 14 essential markers across sex hormones, adrenal function, and a complete thyroid panel. Using highly accurate LC-MS/MS technology through our CLIA-certified partner, ZRT Laboratory, this test is ideal for men experiencing complex hormonal symptoms, andropause, thyroid dysfunction, chronic fatigue, or unexplained changes in body composition, mood, or performance.

What Does This Test Measure?

Sex Hormones (8 Markers)

• Estrone (E1) – an oestrogen present in men; elevated levels are linked to fat gain and hormonal imbalance
• Estradiol (E2) – the primary oestrogen; men need balanced E2 for bone density and cardiovascular health, but excess causes low libido and gynaecomastia
• Estriol (E3) – a weaker oestrogen that helps assess overall oestrogen load in men
• Progesterone (Pg) – supports testosterone production and counteracts oestrogen dominance in men
• Testosterone (T) – the primary male sex hormone; critical for energy, muscle mass, libido, mood, and metabolic health
• DHEA-S (DS) – an adrenal precursor hormone that declines with age; linked to vitality, immune function, and testosterone production
• Cortisol (C) – the stress hormone; chronically elevated cortisol directly suppresses testosterone
• Sex Hormone Binding Globulin (SHBG) – regulates how much testosterone is biologically available; high SHBG causes low-T symptoms even when total testosterone appears normal

Full Thyroid Panel (6 Markers)

• Thyroid Stimulating Hormone (TSH) – the primary screening marker for thyroid function
• Free Triiodothyronine (fT3) – the active thyroid hormone; low fT3 is linked to fatigue, weight gain, and depression
• Free Thyroxine (fT4) – the storage thyroid hormone converted to fT3; key for assessing conversion issues
• Thyroid Peroxidase Antibody (TPOab) – elevated levels indicate autoimmune thyroid disease (Hashimoto’s)
• Thyroglobulin (Tgbn) – a marker for thyroid tissue health and autoimmune activity
• Total Thyroxine (TT4) – measures total thyroxine including protein-bound hormone

Who Is This Test For?

This test is ideal for men experiencing complex or overlapping symptoms that may involve both hormonal and thyroid imbalance, including:

• Persistent fatigue, morning or evening exhaustion
• Low libido or erectile dysfunction
• Loss of muscle mass or increased body fat
• Mood swings, depression, or anxiety
• Brain fog, poor concentration, or increased forgetfulness
• Sleep disturbances or insomnia
• Hot flashes or night sweats (andropause symptoms)
• Unexplained weight gain or slow metabolism
• Hair thinning or loss
• Decreased stamina or physical performance
• High cholesterol or elevated triglycerides
• Heart palpitations or rapid heartbeat
• Cold intolerance or low body temperature
• Bone loss or decreased muscle size
• Fertility concerns

Why Test Hormones and Thyroid Together?

Thyroid and sex hormones are deeply interconnected in men. Thyroid dysfunction can suppress testosterone, raise SHBG, and worsen symptoms of andropause — and vice versa. Many men are treated for low testosterone when the root cause is actually thyroid dysfunction. Testing both systems together gives you and your doctor a complete clinical picture, avoiding misdiagnosis and enabling more targeted treatment.

Understanding Your Key Hormone Systems

Testosterone, Oestrogen & SHBG

Testosterone is the cornerstone of male hormonal health — essential for energy, muscle mass, libido, bone density, and psychological wellbeing. As men age, testosterone declines while oestrogen (produced by conversion of testosterone via aromatase) can rise. High oestrogen in men is linked to gynaecomastia, fat gain, low libido, and mood issues. SHBG regulates how much testosterone is free and active — high SHBG is a common and frequently overlooked cause of low-testosterone symptoms.

DHEA-S & Adrenal Function

DHEA-S is produced by the adrenal glands and is a key precursor to testosterone and other androgens. It peaks in early adulthood and declines steadily with age. Low DHEA-S is associated with fatigue, low mood, reduced immunity, and declining testosterone. It is an important marker of adrenal reserve and overall hormonal vitality in men.

Cortisol & Stress Response

Cortisol follows a daily rhythm — highest in the morning, lowest at night. Chronically elevated cortisol, driven by prolonged stress, directly suppresses testosterone production and disrupts the entire hormonal cascade. Long-term cortisol imbalance is linked to metabolic dysfunction, osteoporosis, cardiovascular disease, and cognitive decline.

Thyroid Function

Thyroid hormones regulate metabolism, energy, temperature, and mood in men. Hypothyroidism is often underdiagnosed in men because symptoms overlap with low testosterone and andropause. This panel includes fT3, fT4, TPO antibodies, thyroglobulin, and TT4 — giving a complete picture of thyroid function and autoimmune activity (Hashimoto’s thyroiditis), which affects men as well as women.

How Does the Test Work?

1. Order your kit – delivered directly to your door across the UK
2. Collect your sample at home – a simple finger-prick blood spot collection, no clinic visit required
3. Post your sample – send it to our ZRT Laboratory using standard post (shipping cost is your responsibility)
4. Receive your results – within 3–5 working days of the lab receiving your sample
5. Review your report – detailed hormone level graphics, numerical values, and specialist commentary from a PhD Hormone Specialist Doctor

👉 View a Sample Test Result Report

What’s Included in the Kit?

• Blood spot collection card
• Lancets for finger-prick sampling
• Full step-by-step instructions
• Laboratory fee (no additional lab costs or hidden charges)
• Valid for 12 months from purchase date

Why We Use ZRT Laboratory

All testing is performed by ZRT Laboratory — a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries.

• Pioneers of at-home dried blood spot (DBS) hormone testing
• Advanced LC-MS/MS and ICP-MS technology for clinical-grade accuracy
• Qualified for the CDC Hormone Standardization (HoSt) Program for testosterone and estradiol
• Personalised reference ranges based on age and sex

Through our partnership with ZRT Laboratory, Hormone Lab UK delivers internationally recognised, research-backed hormone testing to men across the UK and Europe — from the comfort of home.