Test ID: SU-844 | Sample Type: Saliva + Dried Urine | Technology: LC-MS | Laboratory: ZRT Laboratory, CLIA-certified | Specialist Laboratory Interpretation: Included | Results: 3–5 working days after the laboratory receives your samples | Suitable For: Children and Adults | Collect Sample At Home: No Clinic Visit Required
If tiredness, poor sleep, feeling constantly wired, mood changes or brain fog are affecting everyday life, this combined kit provides hormone and neurotransmitter-related information to explore with your practitioner. It also adds selected hormone measurements when these concerns overlap with menstrual changes, menopausal symptoms or reduced libido.
Four saliva cortisol measurements provide a daily profile, alongside Estradiol, Estriol, Estrone, progesterone, testosterone and DHEA-S. The Advanced urinary neurotransmitter panel adds selected compounds, precursors and metabolites, bringing 36 measurements together in one report with reference ranges and specialist interpretation.
Collect four saliva samples and four timed dried urine samples at home. Your numerical and graphical results help you prepare a focused discussion about your symptoms and appropriate next steps.
What Does the Combined Neurotransmitter and Saliva Hormone Test II Measure?
The panel includes 10 saliva hormone measurements and 26 urinary markers, giving 36 measurements in total.
Saliva Hormone Profile Includes:
| Estradiol (E2) Test | Estriol (E3) Test |
| Estrone (E1) Test | Progesterone (Pg) Test |
| Testosterone (T) Test | DHEA-S (DS) Test |
| Morning Cortisol Test | Before-Lunch Cortisol Test |
| Before-Dinner Cortisol Test | Bedtime Cortisol Test |
These are 10 measurements of seven hormones, with cortisol measured four times.
Neuro Advanced Profile Includes:
| Gamma-aminobutyric acid (GABA) Test | Glutamate (Glu) Test |
| Glycine (Gly) Test | Dopamine (DA) Test |
| Epinephrine / Adrenaline (Epi) Test | Norepinephrine / Noradrenaline (NE) Test |
| Histamine (HIST) Test | Serotonin (5-HT) Test |
| Phenethylamine (PEA) Test | DOPAC Test |
| Homovanillic Acid (HVA) Test | 5-Hydroxyindoleacetic Acid (5-HIAA) Test |
| Normetanephrine (NMN) Test | Vanillylmandelic Acid (VMA) Test |
| Tryptophan (Trp) Test | Kynurenine (Kyn) Test |
| Kynurenic Acid (KynAc) Test | 3-Hydroxykynurenine (3-OHKyn) Test |
| Xanthurenate (Xanth) Test | Taurine Test |
| Glutamine Test | Histidine Test |
| N-Methylhistamine Test | Tyrosine Test |
| Tyramine Test | Creatinine (Crtn) Test |
Creatinine is included in the 26-marker profile to help account for urine concentration.
Sample Saliva Test Result Report | Advanced Neurotransmitter Test Report
Not Sure Which Test Is Right for You?
Email info@hormonelab.co.uk with your age, gender, symptoms, medications, supplements, current treatments and questions. We will forward your enquiry to our doctors and aim to respond within 24 hours with a test suggestion.
Could This Combined Profile Help You Explore Your Symptoms?
Fatigue, poor sleep, mood changes, brain fog and reduced libido often occur together. This combined profile provides complementary hormone and urinary neurotransmitter-related measurements, with the added detail of a four-point saliva cortisol profile.
Your practitioner can review the findings alongside your symptom history, routine, cycle stage where applicable and current treatments to make your consultation more focused.
Persistent Tiredness or Fluctuating Energy
Do you feel exhausted despite adequate rest, experience afternoon energy slumps or struggle to maintain stamina?
Markers assessed include:
- Cortisol rhythm (4 measurements)
- DHEA-S
- Testosterone
- Dopamine
- Norepinephrine
- Epinephrine
- Phenethylamine (PEA)
How testing may help: Morning, before-lunch, before-dinner and bedtime cortisol results provide measured daily patterns to review alongside the times you feel tired or more alert. DHEA-S, testosterone and the urinary profile add information when energy concerns occur with low motivation or changes in concentration.
Low Mood, Irritability or Frequent Mood Changes
Mood changes can affect relationships, motivation and daily wellbeing, sometimes alongside menstrual or menopausal concerns.
Markers assessed include:
- Estradiol (E2)
- Estriol (E3)
- Estrone (E1)
- Progesterone
- Serotonin (5-HT)
- Dopamine (DA)
- GABA
- Tryptophan
- 5-HIAA
- DOPAC
- HVA
How testing may help: The saliva results provide selected hormone measurements, while the urine results add neurotransmitters, precursors and metabolites. Reviewing both sets together provides broader laboratory information when emotional changes overlap with sleep, energy or reproductive-health concerns.
Feeling Anxious, Tense, Overwhelmed or Unable to Switch Off
Feeling constantly alert, tense or unable to relax can affect work, sleep and everyday life.
Markers assessed include:
- Cortisol rhythm
- GABA
- Glutamate
- Glycine
- Serotonin
- Norepinephrine
- Epinephrine
- Normetanephrine
- VMA
How testing may help: Four timed saliva cortisol results provide a daily profile to review alongside when you feel tense or overwhelmed. The urinary measurements add information for discussing these concerns with your practitioner, together with your sleep, routine and treatment history.
Poor Concentration, Forgetfulness or Brain Fog
Difficulty focusing, reduced productivity, memory lapses and mental fatigue can make everyday tasks harder.
Markers assessed include:
- Dopamine
- Norepinephrine
- Serotonin
- Glutamate
- Tyrosine
- Tryptophan
- Kynurenine
- Kynurenic Acid
- 3-Hydroxykynurenine
- Estradiol
How testing may help: Urinary compounds, precursors and metabolites add laboratory information to a review of concentration concerns. The saliva hormone results provide another set of findings when brain fog overlaps with disturbed sleep, menstrual changes, menopausal symptoms or changing energy levels.
Difficulty Falling Asleep, Staying Asleep or Waking Refreshed
Trouble switching off, frequent waking or unrefreshing sleep can affect both daytime energy and emotional wellbeing.
Markers assessed include:
- Cortisol rhythm
- Serotonin
- GABA
- Glycine
- Glutamate
- Histamine
- Taurine
How testing may help: Four saliva cortisol measurements provide a daily pattern, including a bedtime result, to review alongside your sleep diary and routine. The other hormone and urinary results add information when sleep concerns occur with mood changes, night sweats or reduced wellbeing.
Reduced Motivation or Enjoyment
A lack of enthusiasm, drive or enjoyment can affect your work, relationships and daily activities.
Markers assessed include:
- Dopamine
- DOPAC
- HVA
- Phenethylamine (PEA)
- Tyrosine
- Testosterone
- DHEA-S
How testing may help: Dopamine is measured alongside its urinary metabolites and the precursor tyrosine. Testosterone and DHEA-S add hormone measurements to review when reduced motivation overlaps with tiredness or changes in sexual wellbeing.
Difficulty Coping With Everyday Stress
Some people feel constantly overwhelmed, emotionally exhausted or unable to unwind after stressful situations.
Markers assessed include:
- Cortisol (morning, before lunch, before dinner, bedtime)
- DHEA-S
- Norepinephrine
- Epinephrine
- GABA
- Serotonin
How testing may help: Timed saliva cortisol results provide a daily profile alongside DHEA-S and urinary neurotransmitter-related findings. Reviewing these with a note of when you feel wired or exhausted helps you prepare a focused discussion about stress, sleep and appropriate next steps.
Low Libido or Changes in Sexual Wellbeing
Reduced sexual desire can occur alongside changes in mood, energy, relationships or stress.
Markers assessed include:
- Testosterone
- DHEA-S
- Estradiol
- Progesterone
- Dopamine
- Serotonin
How testing may help: Selected saliva hormone measurements provide information to review alongside reduced libido and any hormone treatments. The urinary profile adds findings when sexual wellbeing concerns overlap with mood, motivation or sleep changes.
Menstrual Changes, PMS or Premenstrual Mood Symptoms
Cycle-related irritability, emotional sensitivity and changes in wellbeing can make some days feel harder than others.
Markers assessed include:
- Estradiol
- Estrone
- Estriol
- Progesterone
- Serotonin
- Dopamine
- GABA
How testing may help: The saliva results provide estrogen and progesterone measurements to review alongside your symptoms and cycle stage. The urinary findings add information when menstrual concerns occur with changes in mood, sleep or concentration. Follow the saliva collection-day guidance to support interpretation.
Hot Flushes, Night Sweats or Vaginal Dryness
These concerns can occur during perimenopause and menopause, sometimes alongside changes in sleep and emotional wellbeing.
Markers assessed include:
- Estradiol
- Estriol
- Estrone
- Progesterone
- DHEA-S
- Cortisol
How testing may help: The hormone results provide measurements to review alongside your symptoms, cycle stage and any hormone treatment. Four-point cortisol and the urinary profile add information when these concerns overlap with tiredness, poor sleep or mood changes.
Changes in Weight or Body Composition
Changes in weight or body composition may occur alongside tiredness, reduced activity or changes in wellbeing.
Markers assessed include:
- Cortisol
- Estradiol
- Progesterone
- Testosterone
- DHEA-S
- Dopamine
How testing may help: Selected hormone and urinary neurotransmitter-related results add information to a broader review when body-composition concerns overlap with changes in energy, mood or motivation. Your practitioner can discuss the findings alongside diet, activity and health history.
Reduced Strength or Stamina
Reduced stamina, slower recovery or changes in strength can affect exercise and daily activities.
Markers assessed include:
- Testosterone
- DHEA-S
- Cortisol
How testing may help: These hormone measurements provide information to discuss alongside changes in physical wellbeing, activity and recovery. The combined report adds further findings when these concerns occur with tiredness, low motivation or poor sleep.
Why Test Hormones and Neurotransmitters Together?
Hormonal and nervous-system signalling are involved in mood, sleep, energy and sexual wellbeing. The saliva profile provides selected reproductive and adrenal hormone measurements, including a daily cortisol profile. The urinary profile provides a separate set of neurotransmitter-related measurements.
Combining both panels gives your practitioner broader laboratory information within one report, rather than considering either set of findings in isolation.
The urinary panel measures parent neurotransmitters alongside related metabolites, including dopamine with DOPAC and HVA, serotonin with 5-HIAA, and histamine with N-methylhistamine. Reviewing related compounds together provides a broader biochemical picture than considering individual markers alone.
Choosing Between Related Panels
The 33-marker SU-840 kit includes the same selected saliva hormones and Advanced urinary profile with one morning cortisol measurement. SU-844 extends saliva cortisol testing to four collection times.
The 49-marker SU-841 kit combines seven saliva hormone measurements with timed urinary cortisol, cortisone and melatonin-metabolite measurements. The 57-marker Elite kit further extends that urinary combination with additional norepinephrine and epinephrine measurements.
Saliva and Dried Urine Collection Instructions
Collect your samples at home using the materials provided in your SU-844 kit. This panel requires four saliva samples and four dried urine samples. Saliva and urine samples can be collected on separate days.
Before You Begin
Read the full instructions supplied with your kit. Record all current medications, supplements and hormone treatments on your Test Requisition Form.
- Three days before collection: Avoid anti-ageing or anti-wrinkle facial creams and biotin (vitamin B7), including hair and nail supplements.
- The day before and the day of testing: ZRT recommends avoiding bananas, pineapple, nuts, nut butters, alcohol, nicotine, protein powders and protein shakes.
- Before saliva collection: Do not eat, drink anything other than water, or brush your teeth before the first sample or during the two hours before subsequent samples.
Choosing Your Collection Day
Men, children and women who do not menstruate: Collect on any day of the month. If you use hormone treatments, also follow the guidance below.
Women with regular periods: For saliva hormone testing, choose your collection day according to your usual cycle length. Day 1 is the first day of menstrual flow, rather than spotting.
| Usual Cycle Length | Saliva Collection Day |
|---|---|
| 23–26 days | Day 17, 18 or 19 |
| 27–30 days | Day 21, 22 or 23 |
| 31–34 days | Day 25, 26 or 27 |
| Shorter or longer cycles | 5–7 days before your next expected period |
Women with irregular or infrequent periods: Collect on any non-bleeding day.
For dried urine collection: Avoid menstruation or any time blood could enter your urine sample. Urine collection does not require a specific menstrual-cycle day.
Saliva Collection Timing
Begin your morning saliva collection within 30 minutes of waking, using the large 10 ml tube. Use a small 5 ml tube for each later collection.
| Sample | Saliva Collection Time |
|---|---|
| 1 | Upon waking; begin within 30 minutes |
| 2 | Before lunch |
| 3 | Before dinner |
| 4 | Before bed |
How to Collect Saliva
- Wash your hands with soap and water and dry them with a clean towel.
- Rinse your mouth with water, then wait five minutes.
- Allow saliva to pool in your mouth and transfer it into the tube. Fill the tube at least halfway, excluding bubbles. Collection usually takes 15–30 minutes.
- Screw the cap on securely.
- Write your name, collection date and time on the tube label, then return the tube to its bag.
- Repeat at the remaining collection times required for your panel.
If you make a collection mistake, rinse the tube with hot water without soap, shake out the remaining water and allow it to air-dry before restarting at the appropriate time.
Freeze saliva samples if they will not be shipped within 24 hours.
Dried Urine Collection Timing
Collect four urine samples:
| Sample | Collection Time |
|---|---|
| 1 | Your first urination immediately upon waking |
| 2 | Your second urination, approximately two hours after the first collection |
| 3 | Just before dinner |
| 4 | Just before bedtime |
Before the first urine collection, do not eat, drink anything other than water, or take vitamins or supplements. Follow your healthcare provider’s advice about medication timing.
Limit fluid intake to no more than approximately 240 ml (8 oz) during the hour before each urine collection to avoid diluting your sample.
How to Collect Dried Urine
- Remove a collection card from its bag and write your name, collection date and time on it.
- Open the cover and fold it away from the filter paper. Avoid touching the filter paper.
- Fully saturate the paper by urinating directly onto it, or collect urine in a clean cup and dip the paper up to the top black dashed line.
- Hang or tape the card somewhere secure, ensuring the wet paper does not touch anything.
- Allow it to dry completely for at least six hours. Once dry, refold the card, place it in its bag and seal it. Do not leave samples outside the bag for longer than 24 hours.
- Repeat for each collection time.
Missed a urine collection? Collect that sample at the same time the following day. Record the actual date and time on the card and Test Requisition Form.
If You Use Hormone Treatments
Record all hormone treatments on your form. Do not stop prescribed treatment without your healthcare provider’s advice.
- Topical or oral hormones: Follow the kit’s timing instructions. The previous evening’s dose should generally be at least 12 hours before morning collection; oral progesterone may be taken at bedtime.
- Prevent contamination: Use gloves or an applicator for topical hormones for at least two days before collection. Avoid applying hormones to your face, lips or neck. Change sheets, pillowcases and towels the night before collection and avoid surfaces that may contain hormone residue.
- Patches, vaginal rings, pellets or injections: Follow the laboratory’s guidance to collect halfway between doses.
- Troches or sublingual hormones: The laboratory does not recommend saliva testing with these therapies. Discuss blood spot testing with your healthcare provider.
- 7-Keto DHEA: The laboratory advises avoiding it for three days before collection. This does not apply to regular DHEA.
- Steroid medicines: Ask your healthcare provider about appropriate collection timing.
- On the urine collection day: Take your morning hormone dose after the first urine sample and wash your hands thoroughly. Collect the bedtime sample before nighttime hormones. The laboratory advises avoiding vaginal hormone use until after the final urine sample; discuss any timing adjustment with your healthcare provider.
Returning Your Samples
Complete the Test Requisition Form in full. Place all labelled samples, the completed form and any additional paperwork into the test kit box. Ensure urine cards are completely dry and sealed, then return the kit according to the supplied return instructions.
A return envelope is provided. It is not prepaid; customers are responsible for return postage to the laboratory.
Important: Urine samples that are wet, unsealed, excessively diluted or more than 30 days old will not be processed, replaced or refunded.
Read the full laboratory collection instructions.
Advanced LC-MS Technology
This kit uses LC-MS analysis for its saliva hormone and dried urine panels, with specialist laboratory interpretation included to help explain your results.
Convenient At-Home Collection
Complete four saliva collections and four dried urine collections using the supplied materials. No blood draw or clinic visit is required. Follow the kit’s preparation and storage instructions carefully.
How the Test Works
- Order your kit and receive the collection materials.
- Choose your collection day using the supplied hormone-testing guidance.
- Collect four timed saliva samples and four timed dried urine samples.
- Prepare and return the samples according to the kit instructions.
- Receive your report by email, normally within 3–5 working days after the laboratory receives your samples.
What Your Kit Includes
The kit includes the requisition form and symptom checklist, collection materials, detailed collection and shipping instructions, and a return envelope.
Free UK delivery and laboratory analysis are included. The return envelope is not prepaid.
What You Receive With Your Results
Your report includes the 36 measurements in numerical and graphical form, reference ranges, the saliva hormone profile, four-point cortisol results, urinary neurotransmitter-related results and specialist laboratory commentary.
Share the combined report with your practitioner alongside your symptoms, collection times and treatment history. Keeping a note of sleep, energy and stress concerns on your collection day can help make the discussion more focused.
About ZRT Laboratory
All testing is performed by ZRT Laboratory, a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries.
- Pioneers of at-home dried urine neurotransmitter and hormone testing
- Advanced LC-MS/MS technology for clinical-grade accuracy
- Qualified for the CDC Hormone Standardisation (HoSt) Program
- Rigorous internal and external quality assurance programmes
Hormone Lab UK (Testfield UK Ltd) is the official UK test provider for ZRT Laboratory. All samples are analysed by ZRT Laboratory, a CLIA-certified laboratory with over 25 years of experience in hormone, neurotransmitter, and wellness testing.
Kit Fees, Postage and Validity
Laboratory analysis and specialist interpretation are included. Use the kit within 12 months of purchase. Record all medicines, supplements and hormone treatments on the requisition form.
A return envelope is provided. It is not prepaid; customers are responsible for return postage to the laboratory.
Frequently Asked Questions
How can this combined test help me explore my symptoms?
It brings selected saliva hormones, a daily saliva cortisol profile and urinary neurotransmitter-related measurements together in one report. This provides broader laboratory information when sleep, mood, energy, concentration or sexual wellbeing concerns overlap.
What is the benefit of four-point cortisol testing?
It provides saliva cortisol values at morning, before lunch, before dinner and bedtime. Your practitioner can review the measured daily pattern alongside your sleep, routine and the times you feel tired or more alert.
How can the results support a discussion about poor sleep?
The daily cortisol profile includes a bedtime measurement. Reviewing it with the other hormone and urinary findings adds information to your sleep diary, particularly when sleep concerns occur with mood, energy or menopausal symptoms.
Which saliva hormones are included?
Estradiol, Estriol, Estrone, progesterone, testosterone, DHEA-S and cortisol. Cortisol is measured at four collection times.
How are the 36 measurements counted?
The saliva panel includes six hormones measured once plus four cortisol measurements, giving 10 measurements. These are combined with the Advanced 26-marker urinary profile, including creatinine.
How does this compare with the 33-marker SU-840 kit?
Both include the same selected saliva hormones and Advanced urinary profile. SU-844 includes four-point saliva cortisol testing, while the 33-marker SU-840 kit includes one morning cortisol measurement.
How can the report support a discussion about menopausal symptoms?
The estrogen and progesterone measurements provide information to review alongside symptoms, cycle stage and hormone treatment. Four-point cortisol and urinary findings add information when these concerns occur with poor sleep, tiredness or mood changes.
Can the report be useful for PMS or premenstrual mood concerns?
It provides reproductive hormone results alongside urinary neurotransmitter-related findings. Review these with your practitioner and a symptom diary, following the cycle-timing instructions for saliva collection.
How can the results support a discussion about low libido?
Selected hormone measurements, including testosterone, DHEA-S, Estradiol and progesterone, provide information to review alongside sexual wellbeing concerns. The other findings add information when reduced libido overlaps with mood, energy or sleep changes.
Which panels add daily urinary hormone and melatonin-metabolite measurements?
The 49-marker SU-841 kit combines seven saliva hormone measurements with timed urinary cortisol, cortisone and MT6s. The 57-marker Elite kit further adds timed norepinephrine and epinephrine measurements.
How many samples do I collect?
Four saliva samples and four dried urine samples. Their collection schedules differ, so follow the SU-844 timetable above and the instructions supplied with your kit.
When should I collect if I have regular periods?
Choose the saliva collection day according to your usual cycle length using the table above. Day 1 is the first day of menstrual flow. Collect urine on a non-bleeding day.
Can saliva and urine be collected on different days?
Yes. Label every sample with its actual collection date and time, and follow the preparation and storage instructions for each sample type.
What if I use HRT, testosterone or another hormone treatment?
Record all treatments and follow the supplied timing and contamination guidance. Ask your prescriber about any timing adjustment; do not change prescribed treatment without their advice.
What do I receive with my results?
A combined report covering the 36 measurements, with numerical and graphical results, reference ranges, a four-point saliva cortisol profile and specialist laboratory interpretation.
How can I use my report?
Share it with your practitioner alongside your symptoms, sample times, medicines, supplements and hormone treatments. Use the interpretation to prepare questions about the findings and discuss appropriate further assessment or nutrition, lifestyle and wellbeing steps.
