COMPREHENSIVE MALE PROFILES II (SALIVA AND BLOOD SPOT) – Hormone Lab UK

COMPREHENSIVE MALE PROFILES II (SALIVA AND BLOOD SPOT)

  • £589.00


  • Comprehensive Male Profiles II (Saliva & Blood) Tests for 13 Essential Hormones: Saliva: Cortisol Cx4 (Morning, Afternoon, Evening & Bed Time) Blood Spot:  Estradiol (E2), Testosterone (T), DHEA-S (DS),Prostate Specific Antigen (PSA) Sex Hormone Binding Globulin (SHBG),  Free Triiodothyronine (fT3), Free Thryoxine (fT4), Thyroid Stimulating Hormone (TSH) and Thyroid Peroxidase Antibody (TPO) in Men. 
  • Safe and Easy to use
  • Test can be done at the comfort of your home
  • Free delivery in the UK and Ireland
  • Customers are responsible for shipment to laboratory. Please see more information on shipping page.
  • No additional laboratory cost and tax.
  • The Test Kit Pack includes:    

    • Test Requisition Form includes Symptom Checklist    
    • Requisition Form to complete including your personal and medical history    
    • Contains collection instructions       
    • Instructions on How to Use blood spot and Saliva Collection Kit
  • Test Result: You will receive your test result via email within 5-7 working days after Laboratory receives your sample. On your test result you will see your hormone levels in graphics .An easy to understand explanation regarding the functions of the tested hormones by our laboratory professional. You will also see Laboratory's comments on your test result which gives tips and advice on what to do next, a healthy diet, what kind of exercise you should do and some reading materials how to maintain your hormone level balanced.

Having too much or too little of a particular hormone in the body can cause hormonal imbalance in the body. Hormone Imbalance Symptoms are:

  • Burned Out Feeling, Hot Flashes, Decreased Sweating, Cold Body Temperature,  Decreased Stamina, Decreased Flexibility, Slow Pulse Rate, Memory Lapses, Sleep Disturbances, Poor Concentration, Dizzy spells
  • Mood Swings, Decreased Mental Sharpness, Nervous, Headaches, Depressed, Apathy, Anxious, Stress, Aggressive Behaviours, Irritable, Difficulty Sleeping, Mental Fatigue, Morning Fatigue, Increased Forgetfulness, Evening Fatigue,  
  • Allergies, Sensitivity to Chemicals,
  • Decreased Urine Flow,  Increased Urinary Urges
  • Bone Loss, Swelling or Puffy Eyes/face, Nails Breaking or Brittle 
  • Rapid Heartbeat, Low Blood Sugar, High / Low Blood Pressure, Heart Palpitations
  • Oily Skin or Hair, Acne, Thinning skin, Decreased Muscle Size, Neck or Back Pain, Sore Muscles, Increased Joint Pain 
  • Sugar cravings, Alcohol Carving, Food Carving
  • Decreased Erection, Decreased Libido 
  •  Hearing Loss, Ringing in Ears
  • Weight Gain - Breast or Hips, Weight Gain – waist / belly fat
  • Rapid Aging , Infertility Problems, Goiter 

 

Once you received your test result we strongly recommend you to consult your test results with your Doctor or GP to know whether or not any further actions need to be carried out and get started with ample treatment if is needed.

The test must be used within 12 months after purchase date.

MORE INFORMATION ON MALE HORMONE PROFILES

Why Profiles?
When patients have hormone-related symptoms, it is usually not a clear-cut case of one hormone level being abnormal, or even one hormone system. In fact, because of the role that hormones play as chemical messengers to wake up the genome in specific target tissues throughout the body, it makes sense that all hormone systems work in concert with each other to maintain a state of balance. This could be likened to the instruments in an orchestra playing together in harmony; when one instrument is off key or playing too loudly or softly (analogous to too much or too little hormone), the overall harmony is affected. In a similar manner, the adrenal, thyroid, and sex hormones work in harmony, and when one or more of the hormones in any one system become unbalanced, this affects the harmony or balance of the whole system. Symptoms common to hormonal imbalances in the endocrine systems are seen as the body struggles to maintain balance, but does not succeed. Without an overall picture of which hormone systems are affected, it is often difficult to know the best clinical course of action for correcting the imbalance.
Hormone “Profiles” at ZRT are multiple hormone tests bundled into one convenient kit. Priced lower than the sum of the individual tests, these provide a more economical method to assess a patient’s overall hormonal status, giving a better picture of the hormone imbalances that are causing symptoms. Instead of treating a secondary hormonal imbalance caused by an abnormality in only one of the hormonal systems (e.g., low libido caused by low testosterone), you can address the underlying issues that lie at the root of the problem, and therefore, better guide your patients towards overall wellness.
The Problem – Andropause and Low Testosterone
As men age, their levels of testosterone begin to decline, usually beginning around the mid-40s. This heralds what is commonly known as andropause, the male counterpart to menopause. While this is a natural part of aging, the decline in testosterone production by the testes can be more precipitous in some men than others. Excessive weight gain, stress, lack of exercise, and many medications further contribute to a man’s ability to manufacture testosterone, resulting in even lower testosterone levels and leading to symptoms of andropause. These symptoms may include low libido, irritability, depression, loss of muscle mass and strength, weight gain, metabolic syndrome, erectile dysfunction, sleep disturbances, osteoporosis, and adverse changes in the blood lipid profile. Symptoms of androgen deficiency and low testosterone levels are used to establish a diagnosis of hypogonadism. This low testosterone condition was found to increase significantly with age in the Massachusetts Male Aging Study. In the Hypogonadism in Males (HIM) study, hypogonadism was diagnosed in 38.7% of men over 45 years old who presented to primary care offices. However, while this is certainly an option, the solution to the problem may not be a simple case of restoring testosterone levels. For example, some practitioners find that testosterone therapy may be of little benefit unless problems affecting cortisol production are addressed first. The body’s response to stress is mediated by increased cortisol production, and this prepares the body for “fight or flight” by shutting down other processes, including testosterone production. Correcting disorders such as adrenal fatigue or chronic stress may therefore lead to improved testosterone levels and resolve symptoms, without requiring testosterone therapy. Increasing cortisol levels, along with several other endocrine changes, have been reported in men,highlighting the need to obtain a complete hormone profile before initiating any hormone replacement.

 

Saliva and Dried Blood Spot Testing.

Minimally-invasive home test kit.
Testosterone therapy is also not recommended for patients with signs of benign prostatic hypertrophy (BPH) or prostate cancer. While it is now known that testosterone itself does not cause either of these, it is thought to have the potential to exacerbate the problem when already present. This may in fact be a result of local aromatase production in prostate tumors, which increases local conversion of testosterone to estradiol, 
which in turn stimulates tumor growth. Research now indicates a complex relationship between estrogens and androgens in the etiology of prostate cancer, while serum levels of individual endogenous sex hormones have been found to be unrelated to prostate cancer risk. Studies show that estrogens play both adverse and beneficial roles mediated by different types of estrogen receptor. Testosterone’s effects on the prostate are mediated by its more active metabolite, dihydrotestosterone (DHT), produced by the action of 5-alpha reductase type II (5-alpha reductase type I is the predominant form in the skin, and is responsible for the local action of DHT on hair follicles leading to the development of male pattern baldness). Prostate growth can be controlled by 5-alpha reductase inhibitors, and these may also have a role in prostate cancer prevention and treatment.
The Hormones Tested in our Male Profiles and Why 
Estradiol is tested because too much of it, relative to testosterone levels, suppresses testosterone receptors in target tissues and eventually leads to feminizing effects in men, such as breast enlargement. In healthy young men, testosterone is at its highest level and estradiol is very low. However, as men age, this shifts to a higher estradiol/testosterone ratio. Even if testosterone levels are normal, symptoms can indicate
functional testosterone deficiency because of the effects of higher than normal estradiol levels. There are several mechanisms by which relative levels of estradiol and testosterone can change. Weight gain, whether or not this results from low testosterone, results in increased production of aromatase in fat cells, which converts testosterone to estradiol. Rising estradiol levels also cause the liver to produce more SHBG, which has a greater affinity for testosterone than estradiol. This acts to suppress further the amount of circulating free testosterone. Estradiol also decreases luteinizing hormone (LH) production by negative feedback on the pituitary gland, which in turn acts to decrease testicular testosterone production. High estradiol levels can be controlled by weight reduction to decrease the amount of aromatase-producing adipose tissue. There are nutritional and pharmaceutical approaches to aromatase inhibition.
Progesterone is present in men but at a much lower level than found in premenopausal women. Some men supplement with topical progesterone to help with sleep, to support adrenal cortisol production (progesterone is a cortisol precursor), and to counterbalance the effects of estrogens on the prostate. It has also been used as a mild antiandrogen in patients with BPH and to reduce male pattern baldness, because of its competition with testosterone and DHT for androgen receptors. Salivary progesterone levels can, therefore, be useful to monitor supplementation. 
Testosterone is the primary indicator of male hypogonadism and andropause. Many things can contribute to low testosterone levels, including high cortisol levels and high estrogen levels, as described above.Testosterone production in the testes is controlled by the hypothalamic-pituitary-testicular axis, and so dysfunctions of the hypothalamus or pituitary can affect levels, as well as the negative feedback effect of estradiol on LH levels to suppress testosterone production. 
SHBG binds and transports both testosterone and estrogens in the bloodstream, and it therefore regulates the relative amounts of free and bound hormone and consequently their bioavailability to target tissues. SHBG is a protein produced by the liver in response to exposureto any type of estrogen. Testosterone binds about three times more tightly to SHBG than does estradiol, so this increase in SHBG as a result of estrogen exposure causes the relative proportion of bioavailable testosterone to estradiol to decrease even further, exacerbating the symptoms of testosterone deficiency. Many factors, in addition to estrogen exposure, can affect SHBG levels. Thyroid hormone increases SHBG production, whereas insulin, on the other hand, decreases SHBG levels. In young men, testosterone levels are usually high and SHBG low, making most of the testosterone bioavailable. However, as men age, gain weight, and their estrogen levels increase, SHBG also rises, decreasing bioavailable testosterone. Measuring SHBG in blood provides an indication of the overall exposure to estrogens, as well as the bioavailable (free) fraction of testosterone (calculated from the ratio of testosterone to SHBG). 
PSA is a measure of prostate health and high levels can indicate the presence of BPH or advancing prostate cancer. As prostate cells start to become crowded, they produce PSA, which acts to suppress angiogenesis and therefore reduce the blood supply to the surrounding tissue to prevent it from further growth. High levels are therefore seen only as a result of growth that is fairly rapid. It is important to test PSA levels prior to starting testosterone therapy, as a sharp increase in PSA can indicate prostate problems. 
DHEA is a precursor for the production of estrogens and testosterone, and is therefore normally present in greater quantities than all the other steroid hormones. It is mostly found in the circulation in its conjugated form, DHEA sulfate (DHEA-S). Its production, which occurs in the adrenal glands, declines gradually with age. Like cortisol, it is involved with immune function and a balance between the two is essential. Low DHEA can result in reduced libido and general malaise. 
Cortisol is an indicator of adrenal function and exposure to stressors. Under normal circumstances, adrenal cortisol production shows a diurnal variation and is highest early in the morning, soon after waking, falling to lower levels in the evening. Normal cortisol production shows a healthy ability to respond to stress. Low cortisol levels can indicate adrenal fatigue (a reduced ability to respond to stressors), and can leave the body more vulnerable to poor blood sugar regulation and immune system dysfunction. Chronically high cortisol is a consequence of high, constant exposure to stressors, and this has serious implications for long-term health including an increased risk of cancer, osteoporosis, and possibly Alzheimer’s disease10. Free T4, free T3, TSH, and TPO tests can can indicate the presence of an imbalance in thyroid function, which can cause a wide variety of symptoms, including feeling cold all the time, low stamina, fatigue (particularly in the evening), depression, low sex drive, weight gain, and high cholesterol.
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