Male Hormone Test Kit Profile I (Comprehensive) is for measuring 12 essential male hormone levels. This test kit is for the following hormones: Estradiol (E2), Testosterone (T), Dehydroepiandrosterone DHEA-S (DS), Cortisol Morning, Cortisol Noon, Cortisol Evening, Cortisol Night in saliva, Prostate-Specific Antigen (PSA), Thyroid Stimulating Hormone (TSH), Free Triiodothyronine (fT3), Free Thyroxine (fT4), Thyroid Peroxidase Antibody (TPO).
Test Result: You will receive your test result 3-5 working days after the laboratory receives your sample. You will see your hormone levels in graphics and numbers on your test result. You will also see laboratory comments by Hormone Specialist PhD Dr in the comments: you will find Dr analysis of your hormone levels and what to do next.
- Collect samples from the comfort of your home and post them to our lab.
- The test must be used within 12 months after the purchase date.
- The test kit includes a laboratory fee: no additional laboratory cost and tax.
- Customers are responsible for shipping their samples to the laboratory.
Having low or high level of a particular hormone in the body can cause hormonal imbalance. General male hormones, hormonal imbalance and their symptoms are explained below.
Estradiol is tested because too much of it, relative to testosterone levels, suppresses testosterone receptors in target tissues and eventually leads to feminising effects in men, such as breast enlargement. In healthy young men, testosterone is at its highest level, and estradiol is very low. However, as men age, this shifts to a higher estradiol/testosterone ratio. Even if testosterone levels are normal, symptoms can indicate functional testosterone deficiency because of the effects of higher than normal estradiol levels. There are several mechanisms by which relative levels of estradiol and testosterone can change. Weight gain, whether or not this results from low testosterone, results in increased production of aromatase in fat cells, which converts testosterone to estradiol. Rising estradiol levels also cause the liver to produce more SHBG, which has a greater affinity for testosterone than estradiol. This acts to suppress further the amount of circulating free testosterone. Estradiol also decreases luteinizing hormone (LH) production by negative feedback on the pituitary gland, which in turn acts to decrease testicular testosterone production. High estradiol levels can be controlled by weight reduction to reduce the amount of aromatase-producing adipose tissue. There are nutritional and pharmaceutical approaches to aromatase inhibition.
Cortisol is an indicator of adrenal function and exposure to stressors. Under normal circumstances, adrenal cortisol production shows a diurnal variation and is highest early in the morning, soon after waking, falling to lower levels in the evening. Normal cortisol production shows a healthy ability to respond to stress. Low cortisol levels can indicate adrenal fatigue (a reduced ability to respond to stressors) and can leave the body more vulnerable to poor blood sugar regulation and immune system dysfunction. Chronically high cortisol is a consequence of high, constant exposure to stressors, and this has serious implications for long-term health, including an increased risk of cancer, osteoporosis, and possibly Alzheimer’s disease.
Testosterone is the primary indicator of male hypogonadism and andropause. Many things can contribute to low testosterone levels, including high cortisol levels and high estrogen levels, as described above. Testosterone production in the testes is controlled by the hypothalamic-pituitary-testicular axis, and so dysfunctions of the hypothalamus or pituitary can affect levels, as well as the negative feedback effect of estradiol on LH levels to suppress testosterone production
Prostate-Specific Antigen (PSA)
PSA is a measure of prostate health, and high levels can indicate the presence of BPH or advancing prostate cancer. As prostate cells start to become crowded, they produce PSA, which acts to suppress angiogenesis and therefore reduce the blood supply to the surrounding tissue to prevent it from further growth. High levels are therefore seen only as a result of growth that is fairly rapid. It is important to test PSA levels prior to starting testosterone therapy, as a sharp increase in PSA can indicate prostate problems.
Dehydroepiandrosterone DHEA-S (DS)
DHEA-S is a precursor for the production of estrogens and testosterone and is therefore normally present in greater quantities than all the other steroid hormones. It is mostly found in the circulation in its conjugated form, DHEA sulfate (DHEA-S). Its production, which occurs in the adrenal glands, declines gradually with age. Like cortisol, it is involved with immune function, and a balance between the two is essential. Low DHEA can result in reduced libido and general malaise.
Free T4, Free T3, TSH, and TPO
These tests can indicate the presence of an imbalance in thyroid function, which can cause a wide variety of symptoms, including feeling cold all the time, low stamina, fatigue (particularly in the evening), depression, low sex drive, weight gain, and high cholesterol. If you experience any or a combination of those above symptoms, it’s worth to get your hormone level checked using our comprehensive 12-panel male test. This test can help you to identify if you have a hormonal imbalance in your body and eliminate any recurring doubts and fears about what you are feeling.
Why Profile Hormone Testing?
When patients have hormone-related symptoms, it is usually not a clear-cut case of one hormone level being abnormal or even one hormone system. In fact, because of the role that hormones play as chemical messengers to wake up the genome in specific target tissues throughout the body, it makes sense that all hormone systems work in concert with each other to maintain a state of balance. This could be likened to the instruments in an orchestra playing together in harmony; when one instrument is off key or playing too loudly or softly (analogous to too much or too little hormone), the overall harmony is affected. In a similar manner, the adrenal, thyroid, and sex hormones work in harmony, and when one or more of the hormones in any one system becomes unbalanced, this affects the harmony or balance of the whole system. Symptoms common to hormonal imbalances in the endocrine systems are seen as the body struggles to maintain balance, but does not succeed. Without an overall picture of which hormone systems are affected, it is often difficult to know the best clinical course of action for correcting the imbalance. Hormone “Profiles” at ZRT are multiple hormone tests bundled into one convenient kit. Priced lower than the sum of the individual tests, these provide a more economical method to assess a patient’s overall hormonal status, giving a better picture of the hormone imbalances that are causing symptoms. Instead of treating a secondary hormonal imbalance caused by an abnormality in only one of the hormonal systems (e.g., low libido caused by low testosterone), you can address the underlying issues that lie at the root of the problem, and therefore, better guide your patients towards overall wellness.
The Problem – Andropause and Low Testosterone
As men age, their levels of testosterone begin to decline, usually beginning around the mid-40s. This heralds what is commonly known as andropause, the male counterpart to menopause. While this is a natural part of ageing, the decline in testosterone production by the testes can be more precipitous in some men than others. Excessive weight gain, stress, lack of exercise, and many medications further contribute to a man’s ability to manufacture testosterone, resulting in even lower testosterone levels and leading to symptoms of andropause. These symptoms may include low libido, irritability, depression, loss of muscle mass and strength, weight gain, metabolic syndrome, erectile dysfunction, sleep disturbances, osteoporosis, and adverse changes in the blood lipid profile. Symptoms of androgen deficiency and low testosterone levels are used to establish a diagnosis of hypogonadism. This low testosterone condition was found to increase significantly with age in the Massachusetts Male Aging Study. In the Hypogonadism in Males (HIM) study, hypogonadism was diagnosed in 38.7% of men over 45 years old who presented to primary care offices. However, while this is certainly an option, the solution to the problem may not be a simple case of restoring testosterone levels. For example, some practitioners find that testosterone therapy may be of little benefit unless problems affecting cortisol production are addressed first. The body’s response to stress is mediated by increased cortisol production, and this prepares the body for “fight or flight” by shutting down other processes, including testosterone production. Correcting disorders such as adrenal fatigue or chronic stress may, therefore, lead to improved testosterone levels and resolve symptoms, without requiring testosterone therapy. Increasing cortisol levels, along with several other endocrine changes, have been reported in men, highlighting the need to obtain a complete hormone profile before initiating any hormone replacement.