It is a well-known fact that “sitting is the new smoking,” and that our health suffers greatly from inactivity. The human body was meant to be in motion for at least an hour or two a day — this is known to keep the cardiovascular system tuned up as well as preventing excessive weight gain. But did you know that exercise affects levels of neurotransmitters in the body and can actually help you prevent or overcome disorders such as depression?
Depression: One of the Leading Causes of Disability Worldwide
The World Health Organisation has estimated that 350 million people are affected by depression, making it the leading cause of disability worldwide. Less than half of those affected have access to effective treatment, and women suffer from depression more than men.
Earlier attributed to a “chemical imbalance,” the causes of depression are now known to encompass multiple factors including oxidative stress, inflammation, changes in neuroactive hormones that affect nerve function and neurotrophins that control nerve growth, and altered brain volume due to changes in brain-derived neurotrophic factor (BDNF).
If you’re concerned about how your neurotransmitter levels may be contributing to low mood, fatigue or anxiety, our Neurotransmitter Test Kit (LCMS) measures serotonin, dopamine, GABA, glutamate, norepinephrine and more from a simple at-home dried urine sample — with specialist interpretation included.
Exercise: One of the Best Ways to Prevent and Treat Depression
Multiple studies have found that regular exercise has an antidepressant effect — but what is the biological basis for this? A recent review describes the evidence showing that physical exercise reduces the oxidative stress and inflammation that can contribute to depression, and that it increases factors that are reduced in depression, including BDNF levels, hippocampal volume, brain capillarisation (increasing blood supply to the brain), neuronal plasticity, telomere length, and the activity of the monoamine neurotransmitters serotonin, dopamine, and norepinephrine.
Besides, exercise can simply make you feel good — that “runner’s high” feeling comes from the release of endorphins in response to exercise, which have a euphoric effect. Recently, the endocannabinoid anandamide has also been implicated in mediating the benefits of exercise on mood, contributing to a reduction in depression and anxiety.
Exercise Increases Neurotransmitters Depleted in Depressed Patients
Raising brain serotonin levels is the basis of SSRI (selective serotonin reuptake inhibitor) treatment for depressive disorders. Studies have shown that aerobic exercise increases serotonin concentrations, tryptophan availability, and the activity of serotonin receptors. When muscles are working, they take up branched-chain amino acids (BCAAs) as fuel; these BCAAs compete with tryptophan for transport across the blood–brain barrier, and so the reduction in BCAA levels as they are used up by the muscles allows more tryptophan to enter the brain tissue, where it is available for conversion to serotonin.
Since physical exercise helps to keep serotonin levels high, this should not only improve mood but also help prevent depression, and could potentially be used in therapy in place of pharmaceuticals — at least to treat mild depression.
For those who also want to understand how their stress hormones interact with their neurotransmitter balance, our Neurotransmitter and Cortisol Test combines a full dried urine neurotransmitter panel with a 4-point diurnal cortisol profile — ideal for assessing the relationship between stress, adrenal output and mood.
Yoga Increases GABA
People with joint issues or those who have been advised by their doctors not to undertake strenuous activity can still experience the positive effects of exercise on the brain with more gentle forms of exercise such as yoga. Yoga is known for its calming effects on stress and anxiety, and brain levels of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid) have been found to increase during yoga practice.
A study comparing yoga practice with walking — both for 60 minutes 3 times weekly for 12 weeks — found greater improvements in both mood and anxiety symptoms in the yoga group. Brain imaging showed that increased levels of GABA in the thalamic area of the brain were correlated with these positive mood changes. Conditions exacerbated by stress such as depression, anxiety, PTSD, chronic pain, epilepsy, and mood disorders are all associated with low GABA levels and have been shown to improve using drugs that increase activity of the GABAergic system. It has therefore been suggested that regular yoga practice could benefit people with these disorders.
If you suspect that low GABA or imbalanced adrenal hormones are affecting your stress resilience and mood, our Adrenal Function Saliva Test Kit (LCMS) measures DHEA-S and cortisol across the day to reveal how your adrenal glands are responding to chronic stress.
Feel Good About Exercise
Yes, it’s great to win a medal — but you don’t have to be an Olympian to feel good about exercising. Hearing the Olympians’ stories of hard work and dedication to achieve their sporting goals is certainly inspiring, but we can all experience a little bit of that sense of achievement by just starting somewhere and setting our own goals. We can gradually increase activity to a level where we can feel that we are really doing something to take better care of ourselves, and experience that benefit in mood and a feeling of wellbeing as the brain responds. Don’t overdo it, listen to your body (unless it’s telling you to stay on the couch) and award yourself a gold medal for effort.
Original of this article was published on ZRT Laboratory Blog.