WEIGHT MANAGEMENT PROFILE TEST (SALIVA AND BLOOD SPOT)
Weight Management Profile Test Blood and Saliva
- Aids in early detection of insulin resistance, metabolic syndrome and type 2 diabetes. Includes Blood Spot Tests:Thyroid Stimulating Hormone (TSH), Vitamin D (D2, D3), Fasting Insulin (In), Haemoglobin A1c (HbA1c); Saliva Tests: Estradiol (E2), Progesterone (Pg), Testosterone (T), DHEA(S), Diurnal 4x Cortisol (Cx4).
- Test requires Saliva and Blood (dry blood spot) sample
- Contains Saliva and Blood Spot collection kit
- Test sample can be collected at the comfort of your home
- Free delivery in the UK and Ireland
- Customers are responsible for shipment back to laboratory. Please see more information on shipping page.
- No additional laboratory cost and tax.
- Test Result: You will receive your test result via email within 5 working days after Laboratory receives your sample. On your test result you will see your hormone levels in graphics, numbers and Hormone Specialist Doctor's comment which is very helpful for you to decide what to do next.
- Click to see Sample Test Result Report
Weight Management Profile
There has been marked increase in obesity rates over past eight years in the UK— in 1993, 13% men and 16% of women were obese — in 2011 this rose to 24% for men and 26% for women. It is not a coincidence that this is the age when people start to see the impacts of hormonal imbalance. Providers can help by addressing the hormonal connection to obesity to help patients manage their weight and reduce related disease risks.
Our innovative Weight Management Profile detects hormonal imbalances that contribute to obesity, weight gain and difficulty losing or sustaining a healthy weight. Used as a screening tool, the profile also serves as a powerful early indicator of insulin resistance and risks for metabolic syndrome and diabetes.
- Identify hormonal imbalances associated with weight gain and obesity
- Detect early risk markers for insulin resistance, metabolic syndrome and diabetes
Who Benefits from Profile Testing?
Menopausal women/andropausal men with unexplained weight gain, obesity, abdominal fat, high BMI (body mass index), hypo metabolism. Commonly related symptoms include loss of lean muscle, increased appetite and/or sugar cravings, chronic stress, and low thyroid symptoms.
Advantages of Saliva and Blood Spot Testing
- Convenient sample collection at home - no phlebotomist required
- Easy shipment of samples from home to the lab
- Samples stable for several weeks at room temperature
- Excellent correlation with serum/plasma assays
What is Included in the Profile?
Estradiol (E2) at optimal physiological levels in women promotes a healthy distribution of fat in hips, thighs, breasts, and under the skin (subcutaneously). However, in excess and in the absence of progesterone, oestrogen predisposes to unhealthy surplus weight gain in these tissues. Men generally have much lower levels of estradiol and higher testosterone, which is responsible for greater muscle mass and less fat distribution in areas of the body normally seen in women. In overweight men testosterone levels drop and oestrogens raise leading to the same problematic weight gain in the hips, thighs, and breasts (referred to as gynecomastia) as seen in women.
Progesterone (Pg) in addition to keeping oestrogen levels in check, aids weight management by supporting thyroid metabolism, helping the body use and eliminate fats, and acting as a natural diuretic. In the proper ratios, progesterone and oestrogen help to control the way insulin is released and body fat stored. As the precursor of cortisol, progesterone supports adrenal regulation of blood glucose, while its natural calming properties may relieve stress-related overeating and food cravings.
Testosterone (T) and DHEA-S (DS) are androgens that increase lean muscle mass and metabolic rate. As androgen levels decline, muscle mass also decreases with a corresponding increase in adiposity. Low androgens can also reduce vitality and tolerance for exercise. Weight gain itself, with its resulting hormone imbalances; can trigger a drop in testosterone in men. The aromatase enzyme within fat tissue converts androgens to oestrogens, contributing to a female-type body fat distribution, including breast tissue development. In women with polycystic ovarian syndrome (PCOS), high testosterone and DHEA are linked to insulin resistance and weight gain, particularly in the abdomen.
Cortisol (C) imbalances can create problems with blood sugar control, sleep patterns, appetite, food cravings, and exercise tolerance. Under stress, excessive cortisol production particularly in concert with insulin, promotes fat storage in abdominal adipose tissue. This visceral type of fat is closely associated with insulin resistance and metabolic syndrome and thus more hazardous to health. Chronically elevated cortisol is a known risk factor for pre-diabetes and cardiovascular disease.
Thyroid Stimulating Hormone (TSH) elevations, even within the high-normal range, are linked with hypothyroidism,
Low metabolic rate and obesity. Hypothyroidism is linked to elevated cortisol and can also be a consequence of oral oestrogen therapy, which increases the production of binding proteins that reduce thyroid hormone bioavailability.
Vitamin D (D2, D3) deficiency is common in obesity and particularly associated with hyperinsulinemia and visceral fat. Whether by cause or effect, identifying and correcting vitamin D3 deficiency may improve insulin sensitivity.
Fasting Insulin (In), when elevated, is a marker of insulin resistance which precedes metabolic syndrome, PCOS, and type 2 diabetes. Increased levels, particularly in concert with cortisol lead to central obesity and increased inflammatory and other cardiovascular disease markers. Hyperinsulinemia also contributes to decreased testosterone levels in men, but increased testosterone and decreased ovulation in women.
Haemoglobin A1C (HbA1c) is an indirect measure of the average circulating glucose levels over the previous three months. An HbA1c of more than 6% is predictive of type 2 diabetes and cardiovascular disease risk.
The Weight Management Profile allows providers to identify specific hormone imbalances associated with excess weight gain or obesity, vitamin D deficiency, and hypothyroidism in their patients. As a risk assessment panel it allows for early detection of insulin resistance, metabolic syndrome, and type 2 diabetes. The comprehensive test report is designed to help clinicians recommend effective treatments to rebalance hormone levels, address vitamin D and thyroid deficiencies, reduce overall risk for metabolic syndrome, and potentially avoid the onset of type 2 diabetes.
Our Laboratory was one of the first labs to develop saliva and dried blood spot testing and to commercialize this convenient, accurate method of testing for hormone imbalance and early disease indicators. Patients can collect samples at the optimal time with minimal disruption to their lives and work schedules.