Weight Management Test (PROFILE) is for both men and women. The test is for following hormones and vitamins: Thyroid Stimulating Hormone (TSH), Vitamin D (D2, D3), Fasting Insulin (In), Haemoglobin A1c (HbA1c) in blood spot, Cortisol Morning, Cortisol Noon, Cortisol Evening, Cortisol Night in saliva, Estradiol (E2), Testosterone (T), DHEAS (DS), Progesterone (Pg) in saliva.
Test Result: You will receive your test result 3-5 working days after the laboratory receives your sample. You will see your hormone levels in graphics and numbers on your test result. You will also see laboratory comments by Hormone Specialist PhD Dr in the comments: you will find Dr analysis of your hormone levels and what to do next.
- Collect samples from the comfort of your home and post them to our lab.
- The test must be used within 12 months after the purchase date.
- The test kit includes a laboratory fee: no additional laboratory cost and tax.
- Customers are responsible for shipping their samples to the laboratory.
The Purpose of Weight Management Profile Test
Our innovative Weight Management Profile Test detects hormonal imbalances that contribute to obesity, weight gain and difficulty losing or sustaining a healthy weight. It is used as a screening tool; the profile also serves as a powerful early indicator of insulin resistance and risks for metabolic syndrome and diabetes.
- Identify hormonal imbalances associated with weight gain and obesity.
- Detect early risk markers for insulin resistance, metabolic syndrome and diabetes.
Who Benefits from Profile Testing?
Menopausal women and andropausal men can benefit from the test if they have unexplained weight gain, obesity, abdominal fat, high BMI (body mass index) and hypometabolism. Commonly related symptoms include loss of lean muscle, increased appetite and sugar cravings, chronic stress, and low thyroid symptoms.
Advantages of Saliva and Blood Spot Testing
- Convenient sample collection at home - no phlebotomist required
- Easy shipment of samples from home to the lab
- Samples stable for several weeks at room temperature
- Excellent correlation with serum/plasma assays
Estradiol (E2) (Estrogen - Oestrogen)
Estradiol (Estrogen) is at optimal physiological levels in women promotes a healthy distribution of fat in hips, thighs, breasts, and under the skin (subcutaneously). However, in excess and the absence of progesterone, oestrogen predisposes to unhealthy surplus weight gain in these tissues. Men generally have much lower levels of estradiol and higher testosterone, which is responsible for greater muscle mass and less fat distribution in areas of the body normally seen in women. In overweight men testosterone levels drop, and oestrogens raise leading to the same problematic weight gain in the hips, thighs, and breasts (referred to as gynecomastia) as seen in women.
Progesterone is in addition to keeping oestrogen levels in check, aids weight management by supporting thyroid metabolism, helping the body use and eliminate fats, and acting as a natural diuretic. In the proper ratios, progesterone and oestrogen help to control the way insulin is released and body fat stored. As the precursor of cortisol, progesterone supports adrenal regulation of blood glucose, while its natural calming properties may relieve stress-related overeating and food cravings.
Testosterone (T) And DHEAS (DS)
Testosterone and DHEA-S (DS) are androgens that increase lean muscle mass and metabolic rate. As androgen levels decline, muscle mass also decreases with a corresponding increase in adiposity. Low androgens can also reduce vitality and tolerance for exercise. Weight gain itself, with its resulting hormone imbalances; can trigger a drop in testosterone in men. The aromatase enzyme within fat tissue converts androgens to oestrogens, contributing to a female-type body fat distribution, including breast tissue development. In women with the polycystic ovarian syndrome (PCOS), high testosterone and DHEA are linked to insulin resistance and weight gain, particularly in the abdomen.
Imbalances can create problems with blood sugar control, sleep patterns, appetite, food cravings, and exercise tolerance. Under stress, excessive cortisol production, particularly in concert with insulin, promotes fat storage in abdominal adipose tissue. This visceral type of fat is closely associated with insulin resistance and metabolic syndrome and thus more hazardous to health. Chronically elevated cortisol is a known risk factor for pre-diabetes and cardiovascular disease.
Thyroid Stimulating Hormone (TSH)
TSH elevations, even within the high-normal range, are linked with hypothyroidism, low metabolic rate and obesity. Hypothyroidism is linked to elevated cortisol and can also be a consequence of oral oestrogen therapy, which increases the production of binding proteins that reduce thyroid hormone bioavailability.
Vitamin D (D2, D3)
Vitamin D deficiency is common in obesity and particularly associated with hyperinsulinemia and visceral fat. Whether by cause or effect, identifying and correcting vitamin D2 and D3 deficiency may improve insulin sensitivity.
Fasting Insulin (In)
Fasting insulin, when elevated, is a marker of insulin resistance which precedes metabolic syndrome, PCOS, and type 2 diabetes. Increased levels, particularly in concert with cortisol, lead to central obesity and increased inflammatory and other cardiovascular disease markers. Hyperinsulinemia also contributes to decreased testosterone levels in men, but increased testosterone and decreased ovulation in women.
Haemoglobin A1C (HbA1c)
Haemoglobin is an indirect measure of the average circulating glucose levels over the previous three months. An HbA1c of more than 6% is predictive of type 2 diabetes and cardiovascular disease risk.
The Weight Management Profile allows providers to identify specific hormone imbalances associated with excess weight gain or obesity, vitamin D deficiency, and hypothyroidism in their patients. As a risk assessment panel, it allows for early detection of insulin resistance, metabolic syndrome, and type 2 diabetes. The comprehensive test report is designed to help clinicians recommend effective treatments to rebalance hormone levels, address vitamin D and thyroid deficiencies, reduce overall risk for metabolic syndrome, and potentially avoid the onset of type 2 diabetes.