Weight Management Test + Cardio Test (PROFILE)

Regular price £629.00

Tax included.

Weight Management Test plus Cardio Test (Profile) is for following 18 tests in saliva and blood spot both in men and women. Tests are:

  • Thyroid Stimulating Hormone (TSH)
  • Vitamin D (D2, D3)
  • Fasting Insulin (In)
  • Haemoglobin A1c (HbA1c) in blood spot
  • Cortisol Morning 
  • Cortisol Noon
  • Cortisol Evening
  • Cortisol Night in saliva
  • Estradiol (E2)
  • Testosterone (T)
  • DHEAS (DS)
  • Progesterone (Pg) in saliva 
  • Add on High-Sensitivity C-Reactive Protein (hsCRP)
  • Add on Triglycerides (TG)
  • Add on Total Cholesterol (CH)
  • Add on LDL Cholesterol (LDL)
  • Add on VLDL Cholesterol (VLDL)
  • Add on HDL Cholesterol (HDL) in blood spot
  • Test requires Saliva and Blood (dry blood spot) sample
  • Test kit Contains Saliva and Blood Spot collection kits
  • Collecting sample easily at comfort of your home
  • Free Delivery in the UK (International delivery start from £3.99)
  • Customers are responsible for shipping their sample to laboratory.
  • Test kit includes laboratory fee. No additional cost or tax.
  • Test Result: You will receive your test result via email within 3-5 working days after Laboratory receives your sample. On your test result you will see your hormone levels in graphics and numbers. You will also see Laboratory's comments by Hormone Specialist Phd Dr. on your test result which suggests a healthy diet, what kind of exercise you should do and some reading materials how to maintain your hormone level balanced. After receiving your test result we strongly recommend you to show your test result to your GP and see if you need any treatment or further action needs to be taken. 
  • Click to see Sample Test Result Report
  • The test must be used within 12 months after purchase date.

Weight Management Plus Cardio Test (PROFILE) Pack Includes: 

  • Test Requisition Form includes Symptom Checklist    
  • Requisition Form to complete including your personal and medical history    
  • Contains collection instructions       
  • Instructions on How to Use saliva & blood spot Collection Kit
  • Return envelope
  • Shipping instructions
Weight Management Profile PLUS CARDIO (Blood/Saliva)

There has been marked increase in obesity rates over past eight years in the UK and around the world.  It is not a coincidence that this is the age when people start to see the impacts of hormonal imbalance. Providers can help by addressing the hormonal connection to obesity to help patients manage their weight and reduce related disease risks.

Our innovative Weight Management Profile detects hormonal imbalances that contribute to obesity, weight gain and difficulty losing or sustaining a healthy weight. Used as a screening tool, the profile also serves as a powerful early indicator of insulin resistance and risks for metabolic syndrome and diabetes.

Purpose

  •  Identify hormonal imbalances associated with weight gain and obesity
  •   Detect early risk markers for insulin resistance, metabolic syndrome and diabetes

Who Benefits from Profile Testing?

Menopausal women / andropausal men with unexplained weight gain, obesity, abdominal fat, high BMI (body mass index), hypo metabolism. Commonly related symptoms include loss of lean muscle, increased appetite and/or sugar cravings, chronic stress, and low thyroid symptoms.

Advantages of Saliva and Blood Spot Testing

  • Convenient sample collection at home - no phlebotomist required
  • Easy shipment of samples from home to the lab
  • Samples stable for several weeks at room temperature
  • Excellent correlation with serum/plasma assays

What is Included in the Profile?

Estradiol (E2) at optimal physiological levels in women promotes a healthy distribution of fat in hips, thighs, breasts, and under the skin (subcutaneously). However, in excess and in the absence of progesterone, oestrogen predisposes to unhealthy surplus weight gain in these tissues. Men generally have much lower levels of estradiol and higher testosterone, which is responsible for greater muscle mass and less fat distribution in areas of the body normally seen in women. In overweight men testosterone levels drop and oestrogens rise, leading to the same problematic weight gain in the hips, thighs, and breasts (referred to as gynecomastia) as seen in women.

Progesterone (Pg) in addition to keeping oestrogen levels in check, aids weight management by supporting thyroid metabolism, helping the body use and eliminate fats, and acting as a natural diuretic. In the proper ratios, progesterone and oestrogen help to control the way insulin is released and body fat stored. As the precursor of cortisol, progesterone supports adrenal regulation of blood glucose, while its natural calming properties may relieve stress-related overeating and food cravings.

Testosterone (T) and DHEA-S (DS) are androgens that increase lean muscle mass and metabolic rate. As androgen levels decline, muscle mass also decreases with a corresponding increase in adiposity. Low androgens can also reduce vitality and tolerance for exercise. Weight gain itself, with its resulting hormone imbalances can trigger a drop in testosterone in men. The aromatase enzyme within fat tissue converts androgens to oestrogens, contributing to a female-type body fat distribution, including breast tissue development. In women with polycystic ovarian syndrome (PCOS), high testosterone and DHEA are linked to insulin resistance and weight gain, particularly in the abdomen.

Cortisol (C) imbalances can create problems with blood sugar control, sleep patterns, appetite, food cravings, and exercise tolerance. Under stress, excessive cortisol production particularly in concert with insulin, promotes fat storage in abdominal adipose tissue. This visceral type of fat is closely associated with insulin resistance and metabolic syndrome and thus more hazardous to health. Chronically elevated cortisol is a known risk factor for pre-diabetes and cardiovascular disease.

Thyroid Stimulating Hormone (TSH) elevations, even within the high-normal range, are linked with hypothyroidism, low metabolic rate and obesity. Hypothyroidism is linked to elevated cortisol and can also be a consequence of oral oestrogen therapy, which increases the production of binding proteins that reduce thyroid hormone bioavailability.

Vitamin D (D2, D3) deficiency is common in obesity and particularly associated with hyperinsulinemia and visceral fat. Whether by cause or effect, identifying and correcting vitamin D3 deficiency may improve insulin sensitivity.

Fasting Insulin (In), when elevated, is a marker of insulin resistance which precedes metabolic syndrome, PCOS, and type 2 diabetes. Increased levels, particularly in concert with cortisol lead to central obesity and increased inflammatory and other cardiovascular disease markers. Hyperinsulinemia also contributes to decreased testosterone levels in men, but increased testosterone and decreased ovulation in women.

Haemoglobin A1C (HbA1c) is an indirect measure of the average circulating glucose levels over the previous three months. An HbA1c of more than 6% is predictive of type 2 diabetes and cardiovascular disease risk.

ADDITIONAL BLOOD SPOT TESTS: 

Total Cholesterol (CH): Cholesterol is required by the body as a precursor to steroid hormone synthesis and as a component of cell membranes. However, in excessive amounts it is a strong component of coronary heart disease risk because of its contribution to coronary atherosclerosis. Atherosclerotic plaque is largely composed of cholesterol. As with other risk factors, high blood cholesterol levels are more significant when other cardiometabolic parameters are already abnormal, or in patients who already have diabetes or cardiovascular disease. The current National Cholesterol Education Program recommendations for total cholesterol levels are: <200 mg="" dl="borderline" 200="" -="" 239="" high="" data-mce-fragment="1">240 mg/dL = high.

High-Sensitivity C-Reactive Protein (hsCRP): C-reactive protein (CRP) is an established marker of inflammation and has recently been suggested to be an important contributor to the pro-inflammatory and prothrombotic elements of cardiovascular disease (CVD) risk. Extremely high CRP levels are seen in acute inflammatory states, but the small elevations that are indicative of the pro-inflammatory and pro -thrombotic states implicated in the metabolic syndrome require high sensitivity assays, and are thus referred to as hs-CRP levels.  Levels below 3.0 mg/L are considered to be normal; 3.1—10 mg/L is elevated, in the context of CVD risk, and above 10 mg/ L is very high, more likely indicating an acute inflammatory event due to infection or trauma.

Triglycerides (TG): Triglycerides enter the circulation as the end-product of digesting dietary fat, and they are also synthesized by the liver. They are an important energy source for the body and are stored in fat cells. Elevated blood levels, or hypertriglyceridemia, often found in untreated diabetes and obesity, are an established indicator of atherogenic dyslipidemia. The National Cholesterol Education Program defines fasting triglyceride levels of 150 mg/dL or above as one of the diagnostic criteria for metabolic syndrome, although some studies have shown that fasting levels lower than 100 mg/dL should be considered as a more optimal cutoff in coronary heart disease risk assessment. The inflammatory state leading to the development of atherosclerosis may be triggered by “postprandial dysmetabolism,” a condition characterized by unusually high levels of glucose and triglycerides after a meal. Postprandial hypertriglyceridemia indicates the presence of remnant lipoproteins, which are believed to promote atherosclerosis, and it is also linked with insulin resistance and obesity. Several studies have found that triglyceride levels measured 2-4 hours after a meal are highly predictive of cardiovascular events, especially in women. Nonfasting levels >200 mg/dL are suggestive of postprandial dysmetabolism. 

HDL Cholesterol (HDL): Cholesterol bound to high-density lipoprotein (HDL) in the blood is known as HDL cholesterol. A low level of circulating HDL cholesterol is one of the established criteria for the diagnosis of metabolic syndrome, and has long been regarded as a powerful predictor of cardiovascular disease in both diabetics and non-diabetics. In a large cohort from the Framingham Study, a high total cholesterol/HDL cholesterol or LDL cholesterol/HDL cholesterol ratio were associated with increased coronary heart disease risk, and a high HDL cholesterol level was associated with reduced risk, in both men and women. Currently, the LDL cholesterol/HDL cholesterol ratio is regarded as a reliable tool for the evaluation of cardiovascular disease risk. While absolute values of each are still considered by the National Cholesterol Education Program (NCEP) as the optimal diagnostic indicators, the ratios that are currently accepted by doctors and researchers are as follows: total cholesterol:HDL cholesterol ratio – optimally below 4; LDL cholesterol:HDL cholesterol ratio – optimally below 3. The current NCEP recommendation to reduce risk of cardiovascular disease is to maintain an HDL cholesterol level >40 mg/dL in both men and women.

LDL Cholesterol (LDL):

VLDL Cholesterol (VLDL):

Clinical Utility

The Weight Management Profile allows providers to identify specific hormone imbalances associated with excess weight gain or obesity, vitamin D deficiency, and hypothyroidism in their patients. As a risk assessment panel it allows for early detection of insulin resistance, metabolic syndrome, and type 2 diabetes. The comprehensive test report is designed to help clinicians recommend effective treatments to rebalance hormone levels, address vitamin D and thyroid deficiencies, reduce overall risk for metabolic syndrome, and potentially avoid the onset of type 2 diabetes.