Test ID: SB-652 | Sample Type: Saliva + Dried Blood Spot | Technology: LC-MS/MS | Results Time: 3-5 Working Days After Laboratory Receives Sample | Laboratory: ZRT Laboratory - CLIA Certified | Hormone Specialist Doctor Interpretation: Included | Suitable For: Adults and Children | Collect Sample At Home: No Clinic Visit Required
What Does This Test Measure?
Saliva - Sex Hormones (LC-MS/MS): Estradiol (E2), Estriol (E3), Estrone (E1), Progesterone, Testosterone, DHEAS.
Saliva - 4-Point Cortisol Profile: Morning, Noon, Evening, and Night Cortisol.
Blood Spot - Full Thyroid Panel: TSH, Free T3, Free T4, Total T4, TPO Antibodies, Thyroglobulin Antibodies.
Blood Spot - CardioMetabolic Panel: Fasting Insulin, HbA1c, HDL Cholesterol, Triglycerides, Total Cholesterol, hsCRP.
22 markers total - the most comprehensive at-home male health profile available in the UK, covering androgenic balance, the full daily cortisol rhythm, autoimmune thyroid function, and cardiometabolic risk in a single kit.
Related Symptoms
Persistent fatigue, unexplained weight gain, low libido, erectile dysfunction, poor exercise recovery, brain fog, low mood, feeling cold, dry skin, hair thinning, acne, gynaecomastia, sugar cravings, energy crashes, elevated cholesterol or triglycerides on previous testing, insomnia, chronic stress, burnout, or symptoms of low testosterone with normal standard blood results.
Who Should Consider This Test?
- Persistent fatigue that does not improve with rest or sleep
- Unexplained weight gain, particularly around the abdomen
- Low libido, erectile dysfunction, or reduced sexual performance
- Poor recovery from exercise or sustained high workload
- Brain fog, poor concentration, or low mood
- Feeling cold, dry skin, hair thinning, or slow metabolism
- Acne, scalp hair loss, or gynaecomastia
- Sugar cravings, energy crashes, or afternoon slumps
- Elevated cholesterol, triglycerides, or blood sugar on previous testing
- Insomnia, night waking, or unrefreshing sleep
- Chronic stress or burnout
- Symptoms of low testosterone with normal or inconclusive standard blood results
- Currently on TRT and wanting a comprehensive hormonal, thyroid, and metabolic picture
- Diagnosed or suspected Hashimoto's thyroiditis or autoimmune thyroid disease
- Family history of thyroid disease, heart disease, diabetes, or metabolic syndrome
- Men over 35 seeking the single most comprehensive at-home androgenic and metabolic health assessment available
Why This Test Is Particularly Important for Men
- Cortisol is the primary suppressor of testosterone and the primary driver of male cardiometabolic deterioration - through pregnenolone steal, Leydig cell suppression, visceral fat, aromatase-driven oestradiol excess, T3 conversion impairment, and insulin resistance, all simultaneously; the 4-point profile identifies which phase of the day is driving this cascade
- Thyroid dysfunction is a major and systematically missed cause of low testosterone - hypothyroidism directly suppresses testosterone synthesis; cortisol-driven T3 suppression produces identical symptoms with a normal TSH; Hashimoto's is present years before TSH becomes abnormal
- The 4-point cortisol profile is the essential lens for interpreting all other results - each time point (morning, noon, evening, night) has distinct androgenic, thyroid, and metabolic consequences that a single measurement cannot reveal
- Insulin resistance and testosterone decline are mutually reinforcing and thyroid-compounded - fasting insulin is the earliest detectable marker, elevated years before HbA1c becomes abnormal
- hsCRP is the convergence biomarker of the entire male hormonal-metabolic axis - elevated simultaneously by low testosterone, cortisol dysregulation, insulin resistance, oestradiol excess, and Hashimoto's autoimmunity
Not Sure Which Test Is Right for You?
Email us at info@hormonelab.co.uk with your gender, age, symptoms, medications, and any current treatments. We will forward your enquiry to our doctors and respond within 24 hours.
How It Works
- Order your kit - delivered directly to your door
- Collect saliva at four time points (morning before 9am, noon, evening, night) and blood spot via finger-prick
- Post your samples to ZRT Laboratory using the return instructions provided
- Receive your full report by email within 3-5 working days
What You Receive
- All 22 marker results with male-specific reference ranges
- Visual charts for all sex hormones, your full 4-point cortisol daily curve, thyroid panel, and all six cardiometabolic markers
- Integrated clinical interpretation of how testosterone, oestradiol, cortisol, thyroid markers, and cardiometabolic results interact as a single male hormonal-metabolic system by a Hormone Specialist PhD Doctor
- Cortisol-thyroid T3 interaction, Hashimoto's autoimmunity, and insulin resistance assessments
- Personalised next-step recommendations
- Laboratory fee included - no hidden charges
Why We Use ZRT Laboratory
All testing is performed by ZRT Laboratory - a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries.
- Pioneers of at-home dried blood spot (DBS) and saliva hormone testing
- Advanced LC-MS/MS technology for clinical-grade accuracy
- Qualified for the CDC Hormone Standardization (HoSt) Program
- Personalised reference ranges based on age and sex
Through our partnership with ZRT Laboratory, Hormone Lab UK delivers internationally recognised, research-backed hormone testing to people across the UK and Europe - from the comfort of home.
Frequently Asked Questions
Why is this better than standard NHS blood tests?
Standard NHS testing measures total testosterone by immunoassay, uses TSH as the sole thyroid marker, and does not assess cortisol rhythm, thyroid antibodies, fasting insulin, or hsCRP. This test measures free, bioavailable testosterone by LC-MS/MS, provides the full 4-point cortisol rhythm, screens for Hashimoto's, and assesses insulin resistance and cardiovascular inflammation - revealing root causes that standard panels systematically miss.
Can I use this test if I am on TRT or levothyroxine?
Yes. This test is particularly valuable for men on TRT or thyroid medication wanting a complete picture of how their treatment is affecting their entire androgenic, thyroid, and cardiometabolic system.
Is this suitable for men with Hashimoto's or suspected thyroid disease?
Yes - this is the most comprehensive thyroid assessment available in an at-home test for men, with both TPO and Tg antibodies alongside the full thyroid panel, 4-point cortisol, and insulin markers that directly drive autoimmune thyroid activity.
Does the price include the laboratory fee?
Yes. The full laboratory analysis fee is included. There are no additional charges. You are only responsible for posting your samples to the laboratory.
How long is the kit valid for?
The kit must be used within 12 months of the purchase date.
