Add on Neurotransmitter (Neuro Advanced Profile + Saliva Hormones)

Regular price £479.00

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Neuro Advanced Profile + Saliva Hormones in dried urine and saliva containing following 20 tests:

  • Gamma-aminobutyric acid (GABA),
  • Glutamine (Glu),
  • Glycine (Gly),
  • Dopamine (DA),
  • Epinephrine (Epi),
  • Norepinephrine (NE),
  • Histamine (HIST),
  • 5-hydroxytryptophan (5-HT),
  • Phenethylamine (PEA),
  • Dopamine metabolite's (DOPAC),
  • Homovanillic acid (HVA),
  • 5-hydroxyindole 3-acetic acid (5-HIAA),
  • Normetanephrine (NMN),
  • Vanillylmandelic acid (VMA),
  • Creatinine (Crtn).
  • Estradiol (E2) in saliva
  • Progesterone (Pg) in saliva
  • Testosterone (T) in saliva
  • DHEAS (DS) in saliva
  • Cortisol (C) in saliva
  • Test requires dried urine sample
  • Test sample can be collected at the comfort of your home
  • Free delivery in the UK 
  • Customers are responsible for shipping their sample to the laboratory. 
  • Test kit includes laboratory fee: no additional laboratory cost and tax.
  • Click to see >> Advanced Neurotransmitter Test Report
  • Test must be used within 12 months after purchase date. 

Test Result Report: You will receive your test result via email within 3-5 working days after Laboratory receives your sample. On your test result, you will find your hormone levels in graphics and numbers, which makes it easy to understand. You will also find the Laboratory's comments made by Hormone Specialist PhD Dr suggests how to balance your hormones if there are any imbalanced hormones and what to do next. 

The Test Kit pack includes

  • Test Requisition Form includes Symptom Checklist
  • Requisition Form to complete including your personal and medical history
  • Contains collection instructions
  • Cards for collecting dried urine sample
  • Instructions on How to Use Collection Kit
  • Return Envelope
  • Shipping instruction

NEUROTRANSMITTERS PLAY A KEY ROLE in mental conditions, such as depression & anxiety, can occur when neurotransmitter levels are out of balance.

ARE YOU AFFECTED? Just a few causes of suboptimal neurotransmitter levels are stress, diet, toxins, drugs, alcohol & nicotine.

NEUROTRANSMITTERS & YOUR HEALTH

  • Do you suffer with anxiety or depression? 
  • Do you struggle to fall asleep or stay asleep throughout the night? 
  • Men, has your libido fizzled?
  • Women, do you dread the weeks before your period?

If you answered yes to these questions, an underlying neurotransmitter imbalance may be the cause. Simple testing may help you find personalized solutions.

Neurotransmitters & Their Impact

Neurotransmitters are chemical messengers used by the nervous system to relay information from one nerve to another.

The body relays information through the nervous system about anything that it experiences, hears, touches, smells or ingests – continuously communicating back and forth between the brain and the body.

Optimal neurotransmitter balance is required to maintain proper health. Imbalances can cause the brain and the body to be over- or understimulated, producing neurological or psychological symptoms.

Can a Dysregulated Nervous System Impact Health?

Like hormones, neurotransmitters require a delicate balance to keep the body functioning at a peak level.

Genetics, environment, chemicals and nutritional deficiencies are a few factors that can result in over- or under-production of neurotransmitters. Once out of balance, the nervous system begins to compensate – which, in time, can lead to neurological or psychological symptoms.

Some of the more common psychological conditions today are known to be accompanied by neurotransmitter imbalances. However, it’s also possible for individuals to present with similar symptoms yet have unique foundational imbalances. Testing helps clarify these root issues.

Neurotransmitters & Symptoms

Do These Symptoms Sound Familiar?

If you regularly suffer from 3 or more of these symptoms, you might have a neurotransmitter imbalance.

  • ADD/ADHD,
  • Aggression,
  • Anxiety,
  • Fatigue,
  • Forgetfulness,
  • Hyperactivity,
  • Impulsive behaviors,
  • Insomnia,
  • Low libido,
  • Mood swings,
  • Obsessive-compulsive disorder (OCD),
  • Panic attacks,
  • Poor concentration,
  • Pre-menstrual dysphoric disorder (PMDD),
  • Severe PMS,
  • Sleeping problems

Neurotransmitters You Should Know

There are many neurotransmitters in the body. The primary messengers are divided into two groups.

Excitatory:

  • Dopamine, generally regarded as the brain’s pleasure and reward center, plays the central role in addiction, improves attention, focus and motivation, and modulates movement control.
  • Epinephrine and Norepinephrine regulate the “fight or flight” response, elevate blood pressure and heart rate, stimulate wakefulness and reduce digestive activity.
  • Glutamate functions as the “on” switch in the brain. It’s the major excitatory neurotransmitter that decreases sleep, optimizes learning, memory and mood and improves libido.
  • Histamine plays a role in the body as a neurotransmitter that increases metabolism, promotes wakefulness and suppresses appetite.
  • PEA (phenylethylamine) promotes energy, elevates mood, regulates attention, aggression and serves as a biomarker for ADHD.

Inhibitory:

  • GABA functions as the “off” switch in the brain. It’s the major inhibitory neurotransmitter that improves mood, relieves anxiety and promotes sleep.
  • Glycine plays a dual role as a neurotransmitter and amino acid that serves as a building block to proteins, improves sleep quality, calms aggression and serves as an anti-inflammatory agent.
  • Serotonin, generally regarded as the “happiness molecule,” contributes to the feeling of calm and well-being that eases depression and anxiety, supports sleep and decreases appetite.

Neurotransmitter Imbalance & Chronic Conditions

Numerous neurotransmitter imbalances may cause persistent health concerns:

  • Anxiety & Depression: Imbalances are often associated with Glutamate (panic attacks), PEA, Histamine, Serotonin, as well as Epinephrine and Norepinephrine.
  • Fatigue: An imbalance between excitatory and inhibitory neurotransmitters is likely.
  • Impulsivity: GABA, Dopamine and Serotonin are three chemical messengers commonly linked to disorders like ADD, ADHD and OCD.
  • Insomnia: Glutamate, Histamine, Dopamine, GABA and Serotonin are several chemical messengers often linked to sleep disturbances and insomnia.
  • PMS or PMDD: Imbalances such as Serotonin, Dopamine, Norepinephrine and GABA are often involved

Neurotransmitter Testing – Giving a Diagnostic Edge in Treating Mood Disorders.

Mental health disorders affect millions of people and profoundly contribute to the burden of disease in society.

The current treatment paradigm in addressing poor brain health relies on diagnostic tools that encompass the evaluation of clinical signs and symptoms. Despite the lack of testable biomarkers for mood disorders, for many patients, treatments can generally be effective. However, even after treatment frequent relapse episodes can still occur. Furthermore, a large number of patients suffer from treatment-resistant depression . Therefore, selection of the best therapeutic regimen for each patient remains a challenge, and is often discovered through a time-consuming process of trial and error. Also, no single approach works for everyone with any one disorder.

Targeted neurotransmitter testing can help health care practitioners achieve a diagnostic edge beyond the traditional psychological inventory by identifying specific imbalances in neurotransmitter levels. Based on neurotransmitter test results, practitioners can identify specific biochemical heterogeneities for each particular patient, and objectively monitor therapeutic responses during and after intervention. Neurotransmitter testing objectively enhances medical assessment and represents a major advance in the personalization of the treatment of mood disorders.

How Neurotransmitters Relay Information within the Body

The brain orchestrates the delicate interplay between the body and the mind. Structural brain units, the neurons, discharge neurotransmitters. These neurotransmitters provide a communication platform for the brain to fuel internal systems with information. Anything the body senses, feels, hears, smells, touches, or ingests serves as an input that prompts an astoundingly fast response. In the central and peripheral nervous system, neurotransmitters operate as chemical messengers that relay the signal and receive feedback via electrochemical impulses to regulate cognition, memory, emotions, respiration, heart rate and contractility, digestion, metabolism, blood flow and pressure, and hormonal responses. When released from peripheral organs, neurotransmitters can also behave as hormones by diffusing to distant sites via the circulation.

Clinical Utility of Urinary Neurotransmitter Analysis

The etiology of mood disorders is profoundly complex and likely encompasses many different types of neurotransmitters, how they achieve balance in the brain and in the gut axis, and how they each interplay with other hormone systems throughout the body. Appropriate balancing of neurotransmitter signals allows the body to maintain equilibrium. When brain and peripheral neurochemistry become unbalanced, the body will struggle to re-establish physiological integrity, which may present in the form of suboptimal psychological well-being. Excessive or deficient levels of certain neurotransmitters in both the brain and in the periphery are associated with a spectrum of neurobiological disorders, such as depression and anxiety. The measurement of specific imbalances may be a very effective neurobiological tool in guiding targeted intervention, aimed at addressing the individual excess or deficiency in question.

Clinical Validity of Urinary Neurotransmitter Assessment

The importance of effectively assessing and treating mood disorders cannot be overstated. Objectivity is a key element to the therapeutic approach to mood disorders. Currently, the standard of care dictates a trial and error pharmaceutical approach is taken with each patient based on both self and clinician assessments. However, without information yielded from objective clinical testing, selection of the most effective treatment for each particular patient with a mood disorder continues to be a challenge. While this may prove effective for some patients, the potential for harm during those interim treatment failures is a real concern for clinicians and patients alike. Urinary neurotransmitter testing is performed with the goal that therapeutic interventions may be introduced to address, alleviate, and improve a patient’s well-being and has a breadth of data to support the efficacy of the test in clinical practice. Evaluation of neurotransmitter levels in urine provides valuable information about the heterogeneity of patient biochemistry, epigenetics, and how the body functions as a whole. Although the urine test is not a direct measure of brain neurotransmitter levels, it provides relevant information with respect to neurotransmitter regulation in the brain, which can be altered by treatment. The levels in urine often parallel levels in the central nervous system, and the test may therefore assist in the selection of patients with mood issues who might respond to specific pharmaceutical or over-the-counter treatment interventions. In other words, the test provides a means to glean a functional systemic perspective regarding each neurotransmitter in the periphery, which ultimately operates under the control of the brain. How do neurotransmitters end up in urine? Some neurotransmitters are produced in the brain and transported across the blood-brain barrier into blood, and others are produced in the periphery (e.g., norepinephrine and epinephrine). Nephrons, the functional units of the kidney, filter circulating neurotransmitters or their precursors from the blood into urine. For some neurotransmitters, urinary measurements correlate with levels in the central nervous system (e.g., glutamate, PEA), and for others, what ends up in urine is only reflective of peripheral biosynthesis (e. g., serotonin, GABA, dopamine, norepinephrine, epinephrine). Regardless of production origin, neurotransmitter excretion reflects the overall systemic neurotransmitter tone, dysregulation of which may contribute to disease states. The ability to identify abnormality across specific areas of the catecholamine and PEA, GABA/ glutamate, serotonin, histamine, and glycine pathways allows healthcare providers to develop a tailored treatment plan to the specific areas associated with imbalance. 

Dried Urine – A Convenient Testing Option

The nature of urine collection is non-invasive and preferable over the traditional invasive collection approaches such as measurement of cerebrospinal fluid. Even with liquid urine collection the patient experiences the enormous hassle of collecting all urine voids over a 24-hour period into a large jug. To circumvent this inconvenience some labs have settled for collecting only the 2nd void, limiting neurotransmitter results to a single morning time point snapshot. ZRT Laboratory offers an alternative to the liquid urine collection method by offering a simple and convenient collection of four separate urine samples at specific time points throughout the day – 1st morning, 2nd morning (approximately 2 hours after the first collection), early evening, and bedtime. Urine is collected onto filter strips by urinating directly on the strip, or by dipping the filter card in a cup containing the collected urine. The urine cards are then allowed to dry overnight, and sent to ZRT for testing. The convenience of the collection method warrants patient compliance and ease of incorporation into clinical practice.

Considerations 

  • The neurotransmitter test assumes proper kidney function. Neurotransmitter levels are reported in µg/g creatinine, where creatinine is measured from the same sample. This test should not be used in individuals with compromised renal function. 
  • The sample can become very dilute due to increased fluid consumption during the day. Therefore, on the day of testing, individuals should restrict their liquid intake to normal consumption.
  • On the day of testing, individuals are advised to refrain from consuming alcohol, nicotine, bananas, pineapple, and walnuts as they may interfere with testing.

Saliva Testing

Symptom Categories & Corresponding Symptoms – Male

Male Estrogen/Progesterone Deficiency Symptoms

Bone loss, depressed, heart palpitations, hot flashes, neck or back pain, nights sweats and sleeping difficulties

Male Estrogen Dominance/ Progesterone Deficiency Symptoms

Cold body temperature, Irritable, low libido, prostate problems, increased urinary urge, decreased urine flow, breast or hips weight gain.

Male Low Androgens (DHEA/Testosterone Deficiency) Symptoms

Allergies, apathy, body temperature cold, bone loss, burned-out feeling, depressed, decreased erections, evening fatigue, mental fatigue, morning fatigue, decreased flexibility, forgetfulness, headaches, heart palpitations, hot flashes, irritable, joint pain, low libido, decreased mental sharpness, decreased muscle size, muscle soreness, night sweats, rapid aging, ringing in ears, skin thinning, decreased stamina, stress, triglycerides elevated, waist Weight gain.

Male High Androgens (DHEA/Testosterone Deficiency) Symptoms

Acne, aggressive behaviour, anxiety, blood pressure high, hair or shin oily, irritable, nervous, sleeping difficulty, sugar craving, breast or hips weight gain.

Male Low Cortisol Deficiency Symptoms

Low blood pressure, low blood sugar, chemical sensitivity, depressed, dizzy spells, fatigue, infertility, irritable, joint pain, decreased mental sharpness, slow pulse rate, decreased stamina, stress, sugar cravings, swelling or puffy eyes/face.

Male High Cortisol Deficiency Symptoms

Anxious, high blood pressure, depression, forgetfulness, hot flashes, decreased mental sharpness, decreased muscle size, nervousness, night sweats, rapid ageing, skin thinning, sleeping difficulty, stress, sugar cravings, Triglycerides elevated, waist weight gain.

If any symptoms mentioned above are persisting, you might consider using our comprehensive 10-panel hormone test. This test has clear instructions on how to use safely and comfortably. Saliva testing produces a non-invasive use as it does not require the use of any needle or instruments that other testing kits may provide.

Symptom Categories & Corresponding Symptoms – Female

Female Estrogen/Progesterone Deficiency Symptoms

Aches & pains, acne, bone loss, depressed, foggy thinking, increased facial or body hair, heart palpitations, hot flashes, incontinence, infertility, memory lapse, night sweats, rapid ageing, rapid heartbeat, skin thinning, sleep disturbance, tearfulness, increased urinary urge, vaginal dryness and weight Gain-Waist.

Female Estrogen Dominance/ Progesterone Deficiency Symptoms

Anxious, bleeding changes, cold body temperature, breast cancer, fibrocystic breasts, tender breasts, depressed, headaches, infertility, irritable, mood swings, nervousness, uterine fibroids, water retention and hips weight gain.

Female Low Androgens (DHEA/Testosterone Deficiency) Symptoms

Aches & pains, allergies, bone loss, depressed, evening fatigue, morning fatigue, fibromyalgia, headaches, incontinence, decreased libido, memory lapse, decreased muscle size, rapid ageing, skin thinning, stamina degreased and vaginal dryness.

Female High Androgens (DHEA/Testosterone Deficiency) Symptoms

Acne, breast cancer, increased facial or body hair, hair-scalp loss, irritable, triglycerides elevated, and waist weight gain.

Female Low Cortisol Deficiency Symptoms

Aches & pains, allergies, low blood pressure, low blood sugar, cold body temperature, chemical sensitivity, evening fatigue, morning fatigue, fibromyalgia, slow pulse rate, decreased stamina, stress and sugar craving.

 Female High Cortisol Deficiency Symptoms

Anxious, high blood pressure, bone loss, breast cancer, depressed, foggy thinking, hot flashes, infertility, irritable, memory lapse, decreased muscle size, nervous, night sweats, rapid ageing, rapid heartbeat, skin thinning, sleep disturbance, stress, uterine fibroids and waist weight gain.

If any symptoms mentioned above are persisting, you might consider using our comprehensive 5-panel hormone test. This test has clear instructions on how to use safely and comfortably. Saliva testing produces a non-invasive use as it does not require the use of any needle or instruments that other testing kits may provide.

SALIVA TESTING

Saliva testing is used for measuring hormones like cortisol, estrogen, progesterone, DHEA and testosterone. Its non-invasive collection asks patients to spit into a plastic tube. This sampling method allows patients to collect saliva at home at specific times, which is important for accurately measuring hormone levels.

Why do we test hormones in saliva? 

Steroid hormones in the blood are 95-99% bound to carrier proteins such as SHBG, albumin, and CBG. Saliva levels reflect the unbound fraction, which diffuses freely into tissues, and is often described as the “bioavailable” fraction. In many applications, the bioavailable fraction is a more useful clinical parameter than a total serum level. In other applications, such as those where samples must be collected daily or even several times a day, saliva collection is simply more practical. Saliva is preferred to serum in situations where venipuncture stress can affect results, and considered to be the gold standard for collection of adrenal stress hormones in particular. Saliva is also a method of choice for biobehavioral research on hormones and for diurnal cortisol testing, which both require multiple collections making serum testing inconvenient. The simple, noninvasive and flexible collection allowed by ZRT’s test kits is ideal for this process.

  • Salivary cortisol is the method of choice for Cushing’s diagnosis and stress assessment
  • Saliva estradiol/progesterone is effective for monitoring of menstrual cycles and frequently used in fertility studies.
  • Salivary testosterone is a reliable method for diagnosing male hypogonadism
  • Saliva testosterone is comparable to free plasma testosterone in women with PCOS

Saliva testing measures the amount of hormone available to target tissues – the bioavailable amount. For this reason, saliva testing better relates to specific symptoms of excess or deficiency and is a good option for monitoring hormone therapy. ZRT is one of the first labs to measure hormones in saliva and helped establish the method that made saliva hormone testing commercially viable for health care providers and patients around the globe.