Neurotransmitters (Advanced Profile)+ Add on Cortisol & Cortisone (UDH I)

Neurotransmitter testing is a diagnostic procedure designed to measure the levels of different neurotransmitters in the body. These chemical messengers are vital for communication between nerve cells in the brain and the nervous system as a whole. They play a crucial role in regulating essential functions such as mood, behaviour, cognition, and more. By analyzing neurotransmitter levels, this testing offers valuable insights into the balance and activity of these essential chemicals within an individual's system. It can help identify any imbalances or deficiencies in specific neurotransmitters that may be linked to various neurological and psychiatric conditions, including depression, anxiety, attention deficit hyperactivity disorder (ADHD), and many others. Additionally, the Neuro Advanced Profile, which includes the add-on of cortisol and cortisone hormone testing using dried urine, offers a comprehensive evaluation with 38 tests.

Neuro Advanced Profile + Add on Cortisol & Cortisone Hormones (UDH I) in dried urine containing the following 38 tests:

Neuro Advanced Profile (Neurotransmitters)

• Gamma-aminobutyric acid (GABA),
• Glutamate (Glu),
• Glycine (Gly),
• Dopamine (DA),
• Epinephrine (Epi),
• Norepinephrine (NE),
• Histamine (HIST),
• Serotonin (5-hydroxytryptophan (5-HT),
• Phenethylamine (PEA),
• Dopamine metabolites (DOPAC),
• Homovanillic acid (HVA),
• 5-hydroxyindole 3-acetic acid (5-HIAA),
• Normetanephrine (NMN),
• Vanillylmandelic acid (VMA),
• Tryptophan,
• Kynurenine,
• Kynurenic acid,
• 3-Hydroxykynurenine,
• Xanthurenic acid,
• Taurine,
• Glutamine,
• Histidine,
• N-Methylhistamine,
• Tyrosine,
• Tyramine

• Free Cortisol (FCx4),
• Free Cortisone (FCnx4),
• Creatinine (Crtnx5)

Key Features

• Comprehensive Assessment: Neurotransmitter testing provides a comprehensive evaluation of multiple neurotransmitters, allowing for a more detailed understanding of an individual's neurochemical profile. 
• Objective Assessment: Neurotransmitter testing provides an objective measurement of neurotransmitter levels in the body. This can help healthcare providers obtain a more accurate and quantitative understanding of an individual's neurochemical profile, supplementing subjective clinical evaluations.
• Personalised Treatment Approach: By identifying specific neurotransmitter imbalances, testing helps healthcare providers develop personalised treatment strategies tailored to the individual's needs. This can include targeted medication selection, nutrient supplementation, lifestyle modifications, and other interventions to restore balance and optimize neurotransmitter function.
• Diagnostic Aid: Neurotransmitter testing can assist in diagnosing and understanding certain mental health conditions. It can provide objective data that complements clinical assessments, helping clinicians differentiate between different disorders and contributing factors. For example, it may reveal imbalances associated with depression, anxiety, ADHD, or other neurological and psychiatric conditions.
• Targeted Interventions: Neurotransmitter testing can help identify specific deficiencies or imbalances that may be contributing to symptoms or health conditions. This information allows for more targeted interventions, focusing on restoring balance and optimizing neurotransmitter function.
• Monitoring Treatment Progress: The testing can be used to monitor the effectiveness of treatment interventions over time. By measuring neurotransmitter levels before and during treatment, healthcare providers can gauge the impact of interventions and make necessary adjustments to optimise outcomes.
• Differential Diagnosis: Neurotransmitter imbalances can manifest in various mental health conditions and neurological disorders. Neurotransmitter testing can aid in the differential diagnosis process, helping healthcare providers differentiate between different conditions and contributing factors.
• Individualised Nutritional Support: Neurotransmitter testing may reveal deficiencies or imbalances that can be addressed through targeted nutrient supplementation. By identifying specific nutritional needs based on neurotransmitter levels, individuals can be provided with personalised recommendations to support optimal neurotransmitter function.
• Holistic Approach: Neurotransmitter testing promotes a holistic approach to mental health and well-being. It recognises the interplay between neurochemistry, lifestyle factors, and environmental influences, helping to guide treatment decisions beyond pharmaceutical interventions alone.
• Neurotransmitters test is suitable for both adults and children.
• Non-invasive at-home sample collection – 4 strips of dried urine collected throughout the day and ease of storage and shipment.
•  Accurate, timely, and dependable results.
• Dynamic metabolic pathways are complete with precursors, metabolites, enzymes, and cofactors to guide therapies for optimal neurotransmitter support.
• Personalised, clinical literature-cited report to explain the results and provide treatment considerations.
• The test is suitable for both adults and children.
• Free delivery in the UK 
• Customers are responsible for shipping their samples to the Laboratory. 
• The test kit includes a laboratory fee: no additional laboratory cost or tax.
• Click to see >> Advanced Neurotransmitter Test Report
• The test must be used within 12 months after the purchase date. 
• Test Result Report: You will receive your test result via email within 3-5 working days after the Laboratory receives your sample. On your test result, you will find your hormone levels in graphics and numbers, which makes it easy to understand. You will also find the Laboratory's comments made by Specialist PhD. Dr suggests how to balance your hormones if there are any imbalanced hormones and what to do next. 

• Test Requisition Form includes Symptom Checklist
• Requisition Form to complete, including your personal and medical history
• Contains collection instructions
• Cards for collecting a dried urine sample
• Instructions on How to Use Collection Kit
• Return Envelope
• Shipping instruction

• Regulation of Mood and Emotions: Neurotransmitters such as serotonin, dopamine, and norepinephrine are involved in regulating mood, emotions, and feelings of pleasure and reward. Imbalances in these neurotransmitters have been associated with mood disorders like anxiety, depression and bipolar disorder.
• Control of Motor Functions: Neurotransmitters like acetylcholine, dopamine, and gamma-aminobutyric acid (GABA) play a crucial role in controlling and coordinating motor functions. They help regulate muscle movements, balance, and coordination.
• Cognitive Function and Learning: Neurotransmitters like glutamate, acetylcholine, and dopamine contribute to cognitive function, learning, and memory. They facilitate the transmission of signals in brain regions responsible for cognition, attention, and information processing.
• Regulation of Sleep and Wakefulness: Neurotransmitters such as serotonin and norepinephrine help regulate sleep and wakefulness cycles. They influence the timing and quality of sleep, as well as the transition between different sleep stages.
• Modulation of Pain Perception: Certain neurotransmitters, such as endorphins and enkephalins, are involved in the modulation of pain perception. They can inhibit or dampen the transmission of pain signals, resulting in pain relief.
• Autonomic Functions: Neurotransmitters regulate various autonomic functions, including heart rate, blood pressure, digestion, and respiration. Neurotransmitters like acetylcholine and norepinephrine are particularly involved in the autonomic nervous system's control over these functions.
• Regulation of Appetite and Satiety: Neurotransmitters such as serotonin and neuropeptide are involved in the regulation of appetite, satiety, and food intake. Imbalances in these neurotransmitters can contribute to eating disorders and weight management issues.

Overall, neurotransmitters play a vital role in numerous physiological and psychological processes, maintaining the proper functioning of the nervous system and influencing various aspects of human behaviour and experience.

ARE YOU AFFECTED?

Imbalances in neurotransmitters can have significant effects on mental and physical health. Here are some potential outcomes of neurotransmitter imbalances:

• Mood Disorders: Alterations in neurotransmitter levels, particularly serotonin, dopamine, and norepinephrine, are associated with mood disorders such as depression, bipolar disorder, and anxiety disorders. Low levels of serotonin, for example, have been linked to depressive symptoms, while imbalances in dopamine can contribute to mood swings and instability.
• Cognitive Impairment: Disruptions in neurotransmitter balance can impact cognitive function, memory, attention, and information processing. For instance, deficiencies in acetylcholine have been associated with memory impairment and cognitive decline seen in conditions like Alzheimer's disease.
• Sleep Disturbances: Imbalances in neurotransmitters can affect the regulation of sleep-wake cycles. Insufficient serotonin or disruptions in the balance of other neurotransmitters can lead to sleep disorders, such as insomnia or excessive sleepiness.
• Neurological Disorders: Neurotransmitter imbalances have been implicated in various neurological conditions. For example, disruptions in dopamine function are associated with Parkinson's disease, a disorder characterized by motor symptoms, while abnormalities in glutamate and GABA transmission are implicated in epilepsy and seizures.
• Impaired Motor Function: Imbalances in neurotransmitters involved in motor control, such as dopamine, can lead to motor abnormalities. Parkinson's disease, for instance, is characterized by a deficiency of dopamine, resulting in movement difficulties, tremors, and muscle rigidity.
• Addiction and Substance Abuse: Neurotransmitter imbalances, particularly involving dopamine, play a significant role in addiction and substance abuse. Substance use can alter neurotransmitter levels and affect reward pathways in the brain, leading to dependence and addiction.
• Hormonal Imbalances: Neurotransmitters can influence the release and regulation of hormones in the body. Imbalances in neurotransmitters may disrupt the normal functioning of the endocrine system, affecting hormone production, metabolism, and various physiological processes.
• Digestive Disorders: Neurotransmitter imbalances, such as disruptions in serotonin levels, can impact the digestive system. Low serotonin levels have been associated with gastrointestinal issues like irritable bowel syndrome (IBS) and other functional gastrointestinal disorders.

Neurotransmitters & Your Health

• Do you suffer from anxiety or depression?

• Do you struggle to fall asleep or stay asleep throughout the night? 

•  Has your libido fizzled?

• Women, do you dread the weeks before your period?

Premenstrual Symptoms: Changes in neurotransmitter levels, such as fluctuations in serotonin and gamma-aminobutyric acid (GABA), can contribute to premenstrual symptoms in women. Low serotonin levels, in particular, have been linked to mood swings, irritability, and other emotional symptoms experienced before menstruation.

If you answered yes to these questions, an underlying neurotransmitter imbalance might be the cause. Simple testing may help you find personalised solutions.

Neurotransmitters play a crucial role in relaying information and maintaining proper health. Here are some key points about neurotransmitters and their impact:

• Communication: Neurotransmitters facilitate communication between nerve cells (neurons) in the brain and throughout the nervous system. They transmit signals across synapses, the small gaps between neurons, allowing information to be relayed and processed.
• Neurological Function: Neurotransmitters regulate various neurological functions, including sensory perception, motor control, cognition, and emotions. They contribute to the overall functioning and coordination of the nervous system.
• Psychological Function: Imbalances in neurotransmitters can affect psychological well-being and mental health. For example, serotonin is involved in regulating mood, sleep, and appetite, while dopamine plays a role in motivation, reward, and pleasure. Imbalances in these neurotransmitters and others can contribute to conditions such as depression, anxiety, bipolar disorder, and schizophrenia.
• Neurotransmitter Imbalances: When neurotransmitters are not in proper balance, it can lead to neurological or psychological symptoms. For example, low levels of serotonin may be associated with depressive symptoms, while excessive dopamine activity may contribute to psychosis or mania. Imbalances can result from genetic factors, environmental influences, lifestyle choices, and underlying medical conditions.
• Impact on Physical Health: Neurotransmitters also influence physical health beyond the nervous system. For instance, neurotransmitters such as norepinephrine and acetylcholine play a role in regulating heart rate, blood pressure, digestion, and other autonomic functions.
• Treatment Approaches: Understanding neurotransmitter imbalances can help guide treatment approaches. Medications targeting specific neurotransmitter systems (e.g., selective serotonin reuptake inhibitors for depression) aim to restore balance and alleviate symptoms. Lifestyle changes, therapy, and other interventions may also be recommended to support optimal neurotransmitter function.

Optimal neurotransmitter balance is required to maintain proper health. Imbalances can cause the brain and the body to be over-or understimulated, producing neurological or psychological symptoms.

Genetics, environment, chemicals, and nutritional deficiencies are a few factors that can result in over-or under-production of neurotransmitters. Once out of balance, the nervous system begins to compensate – which, in time, can lead to neurological or psychological symptoms.

Some of the more common psychological conditions today are known to be accompanied by neurotransmitter imbalances. However, it’s also possible for individuals to present with similar symptoms yet have unique foundational imbalances. Testing helps clarify these root issues.

• ADD/ADHD,
• Aggression,
• Anxiety,
• Fatigue,
• Forgetfulness,
• Hyperactivity,
• Impulsive behaviours,
• Insomnia,
• Low libido,
• Mood swings,
• Obsessive-compulsive disorder (OCD),
• Panic attacks,
• Poor concentration,
• Pre-menstrual dysphoric disorder (PMDD),
• Severe PMS,
• Sleeping problems

• Behavioral and Emotional Issues: Imbalances in neurotransmitters can contribute to behavioral and emotional issues in children. For example, low levels of serotonin have been associated with anxiety, depression, and mood disorders in children. Imbalances in dopamine may contribute to attention deficit hyperactivity disorder (ADHD) or impulsive behavior.
• Learning and Cognitive Difficulties: Neurotransmitter imbalances can affect learning and cognitive function in children. For instance, imbalances in acetylcholine and glutamate may impact memory, attention, and information processing, which can affect academic performance and cognitive development.
• Sleep Disturbances: Disruptions in neurotransmitter balance can lead to sleep disturbances in children. Imbalances in serotonin and melatonin, which regulate sleep-wake cycles, can result in difficulties falling asleep, staying asleep, or experiencing restful sleep.
• Developmental Disorders: Neurotransmitter imbalances have been implicated in various developmental disorders, such as autism spectrum disorder (ASD). Imbalances in neurotransmitters like serotonin, dopamine, and gamma-aminobutyric acid (GABA) have been associated with ASD symptoms, including social communication difficulties and repetitive behaviors.
• Sensory Processing Issues: Neurotransmitter imbalances can contribute to sensory processing issues in children. Disruptions in neurotransmitter systems involved in sensory integration, such as serotonin and dopamine, can affect how children process and respond to sensory stimuli, leading to sensory sensitivities or sensory-seeking behaviors.
• Treatment Considerations: Addressing neurotransmitter imbalances in children often involves a multifaceted approach. Depending on the specific imbalance and symptoms, interventions may include medication, behavioral therapies, dietary changes, and lifestyle modifications. Working with healthcare professionals, such as pediatricians, psychiatrists, or developmental specialists, can help determine appropriate treatment strategies.

It's important to note that children's neurotransmitter imbalances can be influenced by a variety of factors, including genetic predisposition, prenatal and early life experiences, environmental influences, and comorbid conditions. Professional evaluation and individualised treatment planning are crucial for identifying and addressing neurotransmitter imbalances in children.

Neurotransmitters You Should Know
There are many neurotransmitters in the body. The primary messengers are divided into two groups.

Excitatory:

• Dopamine, generally regarded as the brain’s pleasure and reward centre, plays the central role in addiction, improves attention, focus and motivation, and modulates movement control.
• Epinephrine and Norepinephrine regulate the “fight or flight” response, elevate blood pressure and heart rate, stimulate wakefulness and reduce digestive activity.
• Glutamate functions as the “on” switch in the brain. It’s the major excitatory neurotransmitter that decreases sleep, optimizes learning, memory, and mood, and improves libido.
• Histamine plays a role in the body as a neurotransmitter that increases metabolism, promotes wakefulness, and suppresses appetite.
• PEA (phenylethylamine) promotes energy, elevates mood, regulates attention, aggression and serves as a biomarker for ADHD.

Inhibitory:

• GABA functions as the “off” switch in the brain. It’s the major inhibitory neurotransmitter that improves mood, relieves anxiety, and promotes sleep.
• Glycine plays a dual role as a neurotransmitter and amino acid that serves as a building block to proteins, improves sleep quality, calms aggression, and serves as an anti-inflammatory agent.
• Serotonin, generally regarded as the “happiness molecule,” contributes to the feeling of calm and well-being that eases depression and anxiety, supports sleep and decreases appetite.

• Anxiety & Depression: Imbalances are often associated with Glutamate (panic attacks), PEA, Histamine, Serotonin, as well as Epinephrine and Norepinephrine.
• Fatigue: An imbalance between excitatory and inhibitory neurotransmitters is likely.
• Impulsivity: GABA, Dopamine, and Serotonin are three chemical messengers commonly linked to disorders like ADD, ADHD, and OCD.
• Insomnia: Glutamate, Histamine, Dopamine, GABA, and Serotonin are several chemical messengers often linked to sleep disturbances and insomnia.
• PMS or PMDD: Imbalances such as Serotonin, Dopamine, Norepinephrine, and GABA are often involved

Mental health disorders affect millions of people and profoundly contribute to the burden of disease in society. 

The current treatment paradigm in addressing poor brain health relies on diagnostic tools that encompass the evaluation of clinical signs and symptoms. Despite the lack of testable biomarkers for mood disorders, for many patients, treatments can generally be effective. However, even after treatment, frequent relapse episodes can still occur. Furthermore, a large number of patients suffer from treatment-resistant depression. Therefore, the selection of the best therapeutic regimen for each patient remains a challenge and is often discovered through a time-consuming process of trial and error. Also, no single approach works for everyone with any one disorder.

Targeted neurotransmitter testing can help healthcare practitioners achieve a diagnostic edge beyond the traditional psychological inventory by identifying specific imbalances in neurotransmitter levels. Based on neurotransmitter test results, practitioners can identify specific biochemical heterogeneities for each particular patient and objectively monitor therapeutic responses during and after the intervention. Neurotransmitter testing objectively enhances medical assessment and represents a major advance in the personalization of the treatment of mood disorders.

The brain orchestrates the delicate interplay between the body and the mind. Structural brain units, the neurons, discharge neurotransmitters. These neurotransmitters provide a communication platform for the brain to fuel internal systems with information. Anything the body senses, feels, hears, smells, touches, or ingests serves as an input that prompts an astoundingly fast response. In the central and peripheral nervous system, neurotransmitters operate as chemical messengers that relay the signal and receive feedback via electrochemical impulses to regulate cognition, memory, emotions, respiration, heart rate and contractility, digestion, metabolism, blood flow and pressure, and hormonal responses. When released from peripheral organs, neurotransmitters can also behave as hormones by diffusing to distant sites via circulation.

The Benefit of Testing Free Cortisol, Free Cortisone, and Creatinine with Neurotransmitters Test

Testing Free Cortisol, Free Cortisone, Creatinine along with neurotransmitters can provide several benefits in assessing neurochemical health and related conditions. Here are some potential benefits of combining these tests:

• Comprehensive Neuroendocrine Assessment: Combining neurotransmitter testing with Free Cortisol, Free Cortisone, and Creatinine evaluation allows for a comprehensive assessment of both neurotransmitter and hormonal balance. This holistic approach can provide a more complete understanding of the interactions between neurochemicals and hormones in the body.
• Stress Response Evaluation: Cortisol and cortisone are key hormones involved in the stress response. By measuring Free Cortisol and Free Cortisone levels, along with neurotransmitters, the test can help evaluate how the body's stress response system is functioning and identify any dysregulation that may contribute to stress-related conditions.
• Mood and Mental Health Assessment: Neurotransmitters play a vital role in mood regulation, cognition, and mental well-being. By combining neurotransmitter testing with cortisol assessment, the test can provide insights into the interplay between neurotransmitters and stress hormones, helping to understand the neuroendocrine factors influencing mood disorders, anxiety, and other mental health conditions.
• Adrenal Function Evaluation: Cortisol and cortisone are produced by the adrenal glands. Testing Free Cortisol and Free Cortisone levels, alongside neurotransmitters, can help assess adrenal gland function and identify conditions such as adrenal insufficiency or Cushing's syndrome, which may have both neurological and hormonal implications.
• Sleep and Energy Balance: Cortisol and neurotransmitters are involved in regulating sleep patterns and energy levels. By analyzing cortisol levels and neurotransmitter profiles, the test can aid in identifying imbalances that may contribute to sleep disorders, fatigue, and fluctuations in energy levels.
• Personalized Treatment Approaches: The combined results of neurotransmitter testing and Free Cortisol, Free Cortisone, and Creatinine evaluation allow for a more personalized treatment approach. Healthcare providers can tailor interventions, such as medication selection, nutritional support, lifestyle modifications, and stress management techniques, based on a comprehensive understanding of both neurochemical and hormonal imbalances.

The aetiology of mood disorders is profoundly complex and likely encompasses many different types of neurotransmitters, how they achieve balance in the brain and in the gut axis, and how they each interplay with other hormone systems throughout the body. Appropriate balancing of neurotransmitter signals allows the body to maintain equilibrium. When brain and peripheral neurochemistry become unbalanced, the body will struggle to re-establish physiological integrity, which may present in the form of suboptimal psychological well-being. Excessive or deficient levels of certain neurotransmitters in both the brain and the periphery are associated with a spectrum of neurobiological disorders, such as depression and anxiety. The measurement of specific imbalances may be a very effective neurobiological tool in guiding targeted intervention aimed at addressing the individual excess or deficiency in question.

The importance of effectively assessing and treating mood disorders cannot be overstated. Objectivity is a key element to the therapeutic approach to mood disorders. Currently, the standard of care dictates a trial-and-error pharmaceutical approach is taken with each patient based on both self and clinician assessments. However, without information yielded from objective clinical testing, the selection of the most effective treatment for each particular patient with a mood disorder continues to be a challenge. While this may prove effective for some patients, the potential for harm during those interim treatment failures is a real concern for clinicians and patients alike. Urinary neurotransmitter testing is performed with the goal that therapeutic interventions may be introduced to address, alleviate, and improve a patient’s well-being and has a breadth of data to support the efficacy of the test in clinical practice. Evaluation of neurotransmitter levels in urine provides valuable information about the heterogeneity of patient biochemistry, epigenetics, and how the body functions as a whole. Although the urine test is not a direct measure of brain neurotransmitter levels, it provides relevant information with respect to neurotransmitter regulation in the brain, which can be altered by treatment. The levels in urine often parallel levels in the central nervous system, and the test may therefore assist in the selection of patients with mood issues who might respond to specific pharmaceutical or over-the-counter treatment interventions. In other words, the test provides a means to glean a functional systemic perspective regarding each neurotransmitter in the periphery, which ultimately operates under the control of the brain. How do neurotransmitters end up in urine? Some neurotransmitters are produced in the brain and transported across the blood-brain barrier into the blood, and others are produced in the periphery (e.g., norepinephrine and epinephrine). Nephrons, the functional units of the kidney, filter circulating neurotransmitters or their precursors from the blood into the urine. For some neurotransmitters, urinary measurements correlate with levels in the central nervous system (e.g., glutamate, PEA), and for others, what ends up in urine is only reflective of peripheral biosynthesis (e. g., serotonin, GABA, dopamine, norepinephrine, epinephrine). Regardless of production origin, neurotransmitter excretion reflects the overall systemic neurotransmitter tone, the dysregulation of which may contribute to disease states. The ability to identify abnormality across specific areas of the catecholamine and PEA, GABA/ glutamate, serotonin, histamine, and glycine pathways allows healthcare providers to develop a tailored treatment plan for the specific areas associated with imbalance. 

The nature of urine collection is non-invasive and preferable over the traditional invasive collection approaches, such as the measurement of cerebrospinal fluid. Even with liquid urine collection, the patient experiences the enormous hassle of collecting all urine voids over a 24-hour period into a large jug. To circumvent this inconvenience, some labs have settled for collecting only the 2nd void, limiting neurotransmitter results to a single morning time point snapshot. ZRT Laboratory offers an alternative to the liquid urine collection method by offering a simple and convenient collection of four separate urine samples at specific time points throughout the day – 1st morning, 2nd morning (approximately 2 hours after the first collection), early evening, and bedtime. Urine is collected onto filter strips by urinating directly on the strip or by dipping the filter card in a cup containing the collected urine. The urine cards are then allowed to dry overnight and sent to ZRT for testing. The convenience of the collection method warrants patient compliance and ease of incorporation into clinical practice.

• The neurotransmitter test assumes proper kidney function. Neurotransmitter levels are reported in µg/g creatinine, where creatinine is measured from the same sample. This test should not be used in individuals with compromised renal function. 
• The sample can become very dilute due to increased fluid consumption during the day. Therefore, on the day of testing, individuals should restrict their liquid intake to normal consumption.
• On the day of testing, individuals are advised to refrain from consuming alcohol, nicotine, bananas, pineapple, and walnuts as they may interfere with testing.