Male Hormone Test Profile II

Regular price £379.00

Tax included.

Male Hormone Test Profile II (Comprehensive) is for testing 13 essential hormones in men as follows:

  • Cortisol Morning
  • Cortisol Noon
  • Cortisol Evening
  • Cortisol Night in saliva in saliva
  • Estradiol (E2)
  • Testosterone (T)
  • Dehydroepiandrosterone DHEA-S (DS)
  • Prostate-Specific Antigen (PSA)
  • Sex Hormone Binding Globulin (SHBG)
  • Free Triiodothyronine (fT3)
  • Free Thyroxine (fT4)
  • Thyroid Stimulating Hormone (TSH)
  • Thyroid Peroxidase Antibody (TPO) in blood spot in Men. 
  • Easy and simple to use male hormone test kit 
  • Collecting your sample at the comfort of your home
  • Free delivery in the UK 
  • Customers are responsible for shipping their sample to the laboratory. 
  • The test kit includes a laboratory fee. No additional laboratory cost and tax.
  • Male Hormone Test Profile II Test Result: You will receive your test result via email within 3-5 working days after Laboratory receives your sample. On your test result, you will see your hormone levels in graphics and numbers. You will also see Laboratory's comments on how to balance your hormones made by Hormone Specialist PhD Dr on your test result report. 
  • Click to see Sample Test Result Report

Comprehensive Male Hormone Test Kit Pack includes:    

  • Test Requisition Form includes Symptom Checklist
  • Requisition Form to complete including your personal and medical history
  • Contains collection instructions
  • Vial(s) for collecting saliva and lancet (finger pricks) with blood (dry blood spot) Card
  • Instructions on how to use Collection Kit
  • Return Envelope
  • Shipping instructions

Having a low or high level of a particular hormone in the body can cause hormonal imbalance. General male hormones, hormonal imbalance and their symptoms are explained below.

The Hormones Tested in our Male Profiles and Why 

Estradiol (Estrogen)

Estradiol is tested because too much of it, relative to testosterone levels, suppresses testosterone receptors in target tissues and eventually leads to feminising effects in men, such as breast enlargement. In healthy young men, testosterone is at its highest level, and estradiol is very low. However, as men age, this shifts to a higher estradiol/testosterone ratio. Even if testosterone levels are normal, symptoms can indicate functional testosterone deficiency because of the effects of higher than normal estradiol levels. There are several mechanisms by which relative levels of estradiol and testosterone can change. Weight gain, whether or not this results from low testosterone, results in increased production of aromatase in fat cells, which converts testosterone to estradiol. Rising estradiol levels also cause the liver to produce more SHBG, which has a greater affinity for testosterone than estradiol. This acts to suppress further the amount of circulating free testosterone. Estradiol also decreases luteinizing hormone (LH) production by negative feedback on the pituitary gland, which in turn acts to decrease testicular testosterone production. High estradiol levels can be controlled by weight reduction to reduce the amount of aromatase-producing adipose tissue. There are nutritional and pharmaceutical approaches to aromatase inhibition.

Testosterone 

Testosterone is the primary indicator of male hypogonadism and andropause. Many things can contribute to low testosterone levels, including high cortisol levels and high estrogen levels, as described above. Testosterone production in the testes is controlled by the hypothalamic-pituitary-testicular axis, and so dysfunctions of the hypothalamus or pituitary can affect levels, as well as the negative feedback effect of estradiol on LH levels to suppress testosterone production. 

Prostate-Specific Antigen (PSA)

PSA is a measure of prostate health, and high levels can indicate the presence of BPH or advancing prostate cancer. As prostate cells start to become crowded, they produce PSA, which acts to suppress angiogenesis and therefore reduce the blood supply to the surrounding tissue to prevent it from further growth. High levels are therefore seen only as a result of growth that is fairly rapid. It is important to test PSA levels prior to starting testosterone therapy, as a sharp increase in PSA can indicate prostate problems. 

Dehydroepiandrosterone DHEA-S (DS)

DHEA-S is a precursor for the production of estrogens and testosterone and is therefore normally present in greater quantities than all the other steroid hormones. It is mostly found in the circulation in its conjugated form, DHEA sulfate (DHEA-S). Its production, which occurs in the adrenal glands, declines gradually with age. Like cortisol, it is involved with immune function, and a balance between the two is essential. Low DHEA can result in reduced libido and general malaise. 

Free T4, Free T3, TSH, and TPO

These tests can indicate the presence of an imbalance in thyroid function, which can cause a wide variety of symptoms, including feeling cold all the time, low stamina, fatigue (particularly in the evening), depression, low sex drive, weight gain, and high cholesterol. If you experience any or a combination of those above symptoms, it’s worth to get your hormone level checked using our comprehensive 12-panel male test. This test can help you to identify if you have a hormonal imbalance in your body and eliminate any recurring doubts and fears about what you are feeling.

Sex Hormone Binding Globulin (SHBG)

SHBG binds and transports both testosterone and estrogens in the bloodstream, and it, therefore, regulates the relative amounts of free and bound hormone and consequently their bioavailability to target tissues. SHBG is a protein produced by the liver in response to exposure to any type of estrogen. Testosterone binds about three times more tightly to SHBG than does estradiol, so this increase in SHBG as a result of estrogen exposure causes the relative proportion of bioavailable testosterone to estradiol to decrease even further, exacerbating the symptoms of testosterone deficiency. Many factors, in addition to estrogen exposure, can affect SHBG levels. Thyroid hormone increases SHBG production, whereas insulin, on the other hand, decreases SHBG levels. In young men, testosterone levels are usually high and SHBG low, making most of the testosterone bioavailable. However, as men age, gain weight, and their estrogen levels increase, SHBG also rises, decreasing bioavailable testosterone. Measuring SHBG in the blood provides an indication of the overall exposure to estrogens, as well as the bioavailable (free) fraction of testosterone (calculated from the ratio of testosterone to SHBG). 

Why Profile Hormone Testing?

When patients have hormone-related symptoms, it is usually not a clear-cut case of one hormone level being abnormal or even one hormone system. In fact, because of the role that hormones play as chemical messengers to wake up the genome in specific target tissues throughout the body, it makes sense that all hormone systems work in concert with each other to maintain a state of balance. This could be likened to the instruments in an orchestra playing together in harmony; when one instrument is off key or playing too loudly or softly (analogous to too much or too little hormone), the overall harmony is affected. In a similar manner, the adrenal, thyroid, and sex hormones work in harmony, and when one or more of the hormones in any one system becomes unbalanced, this affects the harmony or balance of the whole system. Symptoms common to hormonal imbalances in the endocrine systems are seen as the body struggles to maintain balance, but does not succeed. Without an overall picture of which hormone systems are affected, it is often difficult to know the best clinical course of action for correcting the imbalance. Hormone “Profiles” at ZRT are multiple hormone tests bundled into one convenient kit. Priced lower than the sum of the individual tests, these provide a more economical method to assess a patient’s overall hormonal status, giving a better picture of the hormone imbalances that are causing symptoms. Instead of treating a secondary hormonal imbalance caused by an abnormality in only one of the hormonal systems (e.g., low libido caused by low testosterone), you can address the underlying issues that lie at the root of the problem, and therefore, better guide your patients towards overall wellness.

The Problem – Andropause and Low Testosterone

As men age, their levels of testosterone begin to decline, usually beginning around the mid-40s. This heralds what is commonly known as andropause, the male counterpart to menopause. While this is a natural part of ageing, the decline in testosterone production by the testes can be more precipitous in some men than others. Excessive weight gain, stress, lack of exercise, and many medications further contribute to a man’s ability to manufacture testosterone, resulting in even lower testosterone levels and leading to symptoms of andropause. These symptoms may include low libido, irritability, depression, loss of muscle mass and strength, weight gain, metabolic syndrome, erectile dysfunction, sleep disturbances, osteoporosis, and adverse changes in the blood lipid profile. Symptoms of androgen deficiency and low testosterone levels are used to establish a diagnosis of hypogonadism. This low testosterone condition was found to increase significantly with age in the Massachusetts Male Aging Study. In the Hypogonadism in Males (HIM) study, hypogonadism was diagnosed in 38.7% of men over 45 years old who presented to primary care offices. However, while this is certainly an option, the solution to the problem may not be a simple case of restoring testosterone levels. For example, some practitioners find that testosterone therapy may be of little benefit unless problems affecting cortisol production are addressed first. The body’s response to stress is mediated by increased cortisol production, and this prepares the body for “fight or flight” by shutting down other processes, including testosterone production. Correcting disorders such as adrenal fatigue or chronic stress may, therefore, lead to improved testosterone levels and resolve symptoms, without requiring testosterone therapy. Increasing cortisol levels, along with several other endocrine changes, have been reported in men, highlighting the need to obtain a complete hormone profile before initiating any hormone replacement.