Blog — neuroendocrine system

PMS and PMDD are more than hormonal mood swings—they are complex neuroendocrine conditions driven by interactions between sex hormones and neurotransmitters like serotonin, GABA, and cortisol. This article explains the science behind menstrual mood disorders and highlights how advanced hormone and neurotransmitter testing from Hormone Lab UK and ZRT Laboratory can help identify imbalances and guide personalised treatment.

Discover the powerful benefits of neurotransmitters test, how it detects chemical imbalances in the brain, improves mood, focus, sleep, and guides personalized treatments for lasting mental and physical wellness.

Stress, Cortisol, and the Hormonal Loop of Anxiety When the body perceives danger, the brain activates the hypothalamus-pituitary-adrenal (HPA) axis — an internal alarm that releases cortisol, the body’s primary stress hormone. For short-term challenges, cortisol is beneficial. It sharpens focus, boosts energy, and prepares muscles for quick action — the classic “fight or flight” response that once ensured survival. When Stress Becomes Chronic Trouble begins when stress never switches off. Prolonged cortisol exposure interferes with healthy brain function, damaging neurons in the hippocampus (responsible for memory) and the prefrontal cortex (which governs decision-making and emotional control). As these areas...