Test ID: SB-647M | Sample Type: Saliva + Dried Blood Spot | Technology: LC-MS/MS | Results Time: 3–5 Working Days After Laboratory Receives Sample | Laboratory: ZRT Laboratory – CLIA Certified | Hormone Specialist Doctor Interpretation: Included | Suitable For: Adults and Children | Collect Sample At Home: No Clinic Visit Required
What Does This Test Measure?
Saliva — Sex & Stress Hormones (LC-MS/MS): Estradiol (E2), Estriol (E3), Estrone (E1), Progesterone, Testosterone, DHEAS, Cortisol (4-point: morning, noon, evening, night).
Blood Spot — Full Thyroid Panel: TSH, Free T3, Free T4, Total T4, TPO Antibodies, Thyroglobulin Antibodies.
13 markers total — a clinically complete picture of androgenic balance, adrenal stress load, oestrogen metabolism, and thyroid function in a single at-home kit.
Related Symptoms
Persistent fatigue, low libido, erectile dysfunction, unexplained abdominal weight gain, poor exercise recovery, brain fog, low mood, feeling cold, dry skin, hair thinning, acne, gynaecomastia, insomnia, chronic stress, burnout, or symptoms of low testosterone with normal standard blood results.
Did You Know?
Hypothyroidism suppresses Leydig cell testosterone production and compounds every symptom of low testosterone. Cortisol-driven T3 suppression produces identical symptoms with a completely normal TSH. And excess oestradiol from aromatase conversion can suppress testosterone and libido while total testosterone appears normal. This test assesses the entire interconnected system — something standard panels do not do.
Who Should Consider This Test?
- Persistent fatigue or exhaustion that does not improve with rest or sleep
- Low libido or reduced sexual interest
- Erectile dysfunction or reduced sexual performance
- Unexplained weight gain, particularly around the abdomen
- Poor recovery from exercise or sustained high workload
- Brain fog, poor concentration, or low mood
- Feeling cold, dry skin, or hair thinning
- Acne or gynaecomastia alongside other hormonal symptoms
- Insomnia, night waking, or unrefreshing sleep
- Chronic stress or burnout
- Symptoms of low testosterone with normal or inconclusive standard blood results
- Currently on TRT or levothyroxine and wanting comprehensive hormonal monitoring
- Men over 35 seeking a complete androgenic, thyroid, and adrenal health baseline
Why This Test Is Particularly Important for Men
- Hypothyroidism suppresses Leydig cell testosterone production — compounding every symptom of low testosterone while thyroid disease goes undetected on a TSH-only test
- Cortisol-driven T3 suppression produces hypothyroid symptoms with a completely normal TSH — only detectable when Free T3 is measured alongside the 4-point cortisol rhythm
- Excess oestradiol from aromatase conversion suppresses testosterone via the HPG axis — causing symptoms of androgen deficiency with normal total testosterone values
- The 4-point cortisol rhythm reveals which phase of the day is driving androgenic and thyroid suppression — something a single cortisol measurement cannot identify
- TPO and Tg antibodies detect autoimmune thyroid disease years before TSH becomes abnormal — the most common cause of thyroid dysfunction in men under 50
Not Sure Which Test Is Right for You?
Email us at info@hormonelab.co.uk with your gender, age, symptoms, medications, and any current treatments. We will forward your enquiry to our doctors and respond within 24 hours.
How It Works
- Order your kit — delivered directly to your door
- Collect saliva at four time points (morning before 9am, noon, evening, night) and blood spot via finger-prick
- Post your samples to ZRT Laboratory using the return instructions provided
- Receive your full report by email within 3–5 working days
What You Receive
- All 13 marker results with male-specific reference ranges
- Visual charts for all seven saliva hormones, your full cortisol curve, and thyroid panel values
- Written interpretation by a Hormone Specialist PhD Doctor
- Personalised next-step recommendations
- Laboratory fee included — no hidden charges
Why We Use ZRT Laboratory
All testing is performed by ZRT Laboratory — a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries.
- Pioneers of at-home dried blood spot (DBS) and saliva hormone testing
- Advanced LC-MS/MS technology for clinical-grade accuracy
- Qualified for the CDC Hormone Standardization (HoSt) Program
- Personalised reference ranges based on age and sex
Through our partnership with ZRT Laboratory, Hormone Lab UK delivers internationally recognised, research-backed hormone testing to people across the UK and Europe — from the comfort of home.
Frequently Asked Questions
Why do men need oestrogen tested?
Men produce oestradiol through aromatase conversion of testosterone. Excess oestradiol suppresses testosterone, causes gynaecomastia, and drives fat accumulation. Measuring all three oestrogens alongside testosterone reveals whether the androgen-oestrogen ratio is clinically balanced.
Why saliva instead of blood for sex hormones?
Saliva measures bioavailable (free, active) hormones — the fraction actually reaching your cells. Blood tests measure total hormone including the bound, inactive fraction, which can mask imbalances most relevant to symptoms.
Can I use this test if I am on TRT or levothyroxine?
Yes. This test is particularly valuable for men on TRT wanting to understand their oestradiol balance, cortisol pattern, and thyroid function alongside testosterone.
Why measure cortisol at four time points?
A single cortisol measurement cannot distinguish between adrenal burnout, high morning reactivity, evening elevation, or night excess — each with different effects on testosterone and thyroid function. The 4-point profile captures the full daily adrenal rhythm.
Does the price include the laboratory fee?
Yes. The full laboratory analysis fee is included. There are no additional charges. You are only responsible for posting your samples to the laboratory.
How long is the kit valid for?
The kit must be used within 12 months of the purchase date.
