Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — wellness profile

Single nucleotide variations (SNVs) in the enzymes that metabolise estrogen can significantly alter breast cancer risk — in some cases by as much as 12-fold when multiple variants combine. In this detailed scientific overview, Jillian Harrington PhD of ZRT Laboratory explains how variations in CYP11A1, CYP19A1 (aromatase), CYP1B1, COMT and MnSOD affect the estrogen metabolism pathway, why catechol estrogens are dangerous, and how methylation testing can reveal individual vulnerability.

As the days shorten and sunlight fades, four key hormonal systems come under pressure: vitamin D, serotonin, cortisol and melatonin. For those susceptible to Seasonal Affective Disorder (SAD), the disruption of these interconnected rhythms can trigger depression, fatigue, poor sleep and low mood. This article explains the science behind the SAD hormone pattern — and what you can do to support your body through the darker months.

Norepinephrine and epinephrine follow a distinct diurnal rhythm — rising through the morning, peaking in the afternoon, and falling at night. When this pattern is disrupted by chronic stress, the consequences ripple through every hormonal system in the body. Learn how the stress response works and how dried urine testing can reveal imbalances.