Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — Estrogen Metabolism

Discover how the estrobolome — the gut microbiome’s role in oestrogen metabolism — influences hormonal balance, estrogen dominance, and conditions such as PCOS, endometriosis, and breast cancer. Learn how diet, dysbiosis, and liver detoxification pathways interact with your hormones, and how targeted testing can help you monitor and support healthy oestrogen clearance.

Single nucleotide variations (SNVs) in the enzymes that metabolise estrogen can significantly alter breast cancer risk — in some cases by as much as 12-fold when multiple variants combine. In this detailed scientific overview, Jillian Harrington PhD of ZRT Laboratory explains how variations in CYP11A1, CYP19A1 (aromatase), CYP1B1, COMT and MnSOD affect the estrogen metabolism pathway, why catechol estrogens are dangerous, and how methylation testing can reveal individual vulnerability.

What do heavy metals, neurotransmitters and hormone imbalances have in common? In this detailed case study, Dr. Kate Placzek examines Loretta — a 62-year-old postmenopausal woman with breast cancer — and shows how comprehensive testing can reveal the complex biochemical picture behind a cancer diagnosis. A compelling read for anyone interested in the role of hormones and toxic exposure in breast health.

Estrogen dominance — an excess of oestrogen relative to progesterone — is one of the most common hormonal imbalances in women. From heavy periods and mood swings to breast tenderness and weight gain, the symptoms are wide-ranging. Discover the causes, what to test, and how to restore balance.

One in eight women will be diagnosed with breast cancer in their lifetime. But many risk factors are modifiable — including hormone imbalance and excess weight. Discover the two most important actions women can take to reduce breast cancer risk, and how hormone testing can help identify hidden imbalances before they become a problem.