Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — progesterone supplementation

Hot flushes, night sweats, anxiety, insomnia and brain fog — menopause can feel overwhelming. But what is actually happening biochemically? In this case study, Dr. Kate Placzek and Dr. Allison Smith walk through the test results of Julia, a newly postmenopausal woman, showing exactly how hormone and neurotransmitter imbalances drive menopausal symptoms — and what can be done about it.

When sex hormone test results show both oestradiol (E2) and progesterone (Pg) within normal ranges, yet symptoms persist, the Pg/E2 ratio provides a critical additional layer of clinical insight. A low ratio points to oestrogen dominance; a high ratio to progesterone dominance — each requiring a different therapeutic response. This article explains how the ratio is calculated, when it is clinically relevant, and how a real-world case illustrates its practical value.

The latest research confirms what Dr. John Lee and Dr. David Zava argued decades ago: maintaining healthy progesterone levels in proper balance with oestrogen is one of the most powerful tools women have for preventing and recovering from breast cancer. This article outlines seven practical steps to restore hormone balance and reduce breast cancer risk.

A landmark study published in Nature confirmed what Dr. John Lee and Dr. David Zava argued over a decade ago: natural progesterone — unlike synthetic progestins — can slow or even shrink ER+/PR+ breast cancer tumours. This article explains the receptor science behind the findings and what it means for women’s hormone health.

Explore the complex relationship between hormonal contraception, mood changes, and depression risk — particularly in teenagers and women sensitive to hormonal fluctuations. Learn the difference between natural progesterone and synthetic progestins, how estrogen and progesterone influence neurotransmitters like serotonin and GABA, and why some women may experience depressive symptoms, anxiety, or emotional changes while using hormonal contraceptives. Discover how hormone and neurotransmitter testing may help provide deeper insight into mood-related symptoms linked to birth control use.