Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — SHBG

Why a Hormone Profile Is Better Than a Single Test. When men experience hormone-related symptoms (like low libido, fatigue, weight gain, or mood changes), it’s rarely just one hormone causing the issue. A simple testosterone check may miss the bigger picture.

Fertility Mapping: Navigating Fertility with PCOS and Insulin Resistance (Part II)By Dr. Alison McAllister Polycystic Ovary Syndrome (PCOS) is a complex, multifactorial condition influenced by disruptions in hormone receptors, metabolism, neurotransmitter function, and nutrient balance. As a lifelong disorder, PCOS is a leading contributor to infertility, weight gain, and an increased risk for cardiometabolic issues. In this blog post, we dive deeper into laboratory testing, helping healthcare providers understand which tests are critical for women suspected of having PCOS. Lab Testing for PCOS PCOS is most commonly diagnosed through the Rotterdam Criteria, a diagnostic framework that considers various indicators, including...

Saliva hormone testing is one of the most accurate and convenient ways to measure bioavailable hormones — the fraction that is actually active in your body's tissues. Unlike standard blood tests, which measure total hormone levels including protein-bound fractions that cells cannot use, saliva testing captures only the free, unbound hormones that drive real physiological effects. This guide explains how saliva testing works, which hormones it measures, why it is clinically superior for monitoring hormone therapy, and how to choose the right test for your health goals.

Low testosterone in older men, often referred to as “male menopause” or even “andropause” is fairly well known — and testosterone replacement therapy in this age group has not been without its share of controversy, particularly with respect to heart health. Proper testing and dosing are all-important, as well as understanding a man’s physiology and all the factors that affect testosterone levels. For example, when giving testosterone transdermally it is critical to use testing methods such as dried blood spot or saliva to properly assess absorption of testosterone into the body, avoiding the problem of overdosing to achieve “normal” serum levels. But while...

By Dr. Allison Smith, ZRT Laboratory Sex Hormone Binding Globulin (SHBG) is one of the most overlooked variables in hormone health. It directly controls how much testosterone is biologically active in your body — yet it rarely appears on standard blood panels. Whether you're dealing with symptoms of low testosterone, androgen excess, or unexplained hormonal imbalance, understanding SHBG is essential to getting the full picture. What is SHBG? SHBG is a protein produced primarily in the liver that binds tightly to testosterone — and to a lesser degree, oestradiol (E2) and dihydrotestosterone (DHT) — and carries them through the bloodstream....