Wellness Metrics Profile +Cardio Profile is for both men and women. The test is for the following 22 hormones and vitamins:
- Thyroid Stimulating Hormone (TSH),
- Vitamin D2,
- Vitamin D3,
- Fasting Insulin (In),
- Haemoglobin A1c (HbA1c) in blood spots.
- Cortisol Morning,
- Cortisol Noon,
- Cortisol Evening,
- Cortisol Night,
- Estradiol (E2),
- Testosterone (T),
- DHEAS (DS),
- Progesterone (Pg) in saliva.
Add on Cardio Profile
- Add on High-Sensitivity C-Reactive Protein (hsCRP),
- Add on Triglycerides (TG),
- Add on Total Cholesterol (CH),
- Add on LDL Cholesterol (LDL),
- Add on VLDL Cholesterol (VLDL),
- Add HDL Cholesterol (HDL) in the blood spot.
Add on Thyroid Profile
- Add on Free Thyroxine Test (fT4),
- Add on Free Triiodothyronine Test (fT3),
- Add on Thyroid Peroxidase Antibody Test (TPO) in blood spot.
Test Result: You will receive your test result 3-5 working days after the laboratory receives your sample. You will see your hormone levels in graphics and numbers on your test result. You will also see laboratory comments by Hormone Specialist PhD Dr in the comments: you will find Dr analysis of your hormone levels and what to do next.
- Collect samples from the comfort of your home and post them to our lab.
- The test must be used within 12 months after the purchase date.
- The test kit includes a laboratory fee: no additional laboratory cost and tax.
- Customers are responsible for shipping their samples to the laboratory.
Wellness Metrics Profile
The adrenal, thyroid, and sex hormones work together to maintain a state of balance in the body. When one or more hormones are outside optimal ranges, this affects the harmony of the whole system. The Wellness Metrics Profile identifies specific imbalances of one or more hormones that govern key aspects of our health, contributing to immunity, mood changes, energy, libido, altered metabolism, increased body fat deposition, and food/sugar cravings, and includes tests identifying increased risks for cardiometabolic disease and diabetes.
The comprehensive test report is designed to help clinicians recommend effective treatments to rebalance sex hormone and adrenal hormone levels, address vitamin D and thyroid deficiencies, reduce overall risk for metabolic syndrome, and potentially avoid type 2 diabetes and other chronic diseases.
Who Benefits from Wellness Metrics Profile Testing?
- Excessive fatigue
- Weight gain, especially in the waist (belly fat)
- Sugar cravings
- Chronic stress
- Low sex drive
- Premenopausal symptoms of estrogen excess or progesterone deficiency
- Menstrual bleeding abnormalities
- Excessive facial/body hair
- Menopausal symptoms
- Hair loss
Estradiol (E2) (Estrogen - Oestrogen)
Estradiol (Estrogen) is at optimal physiological levels in women and promotes a healthy distribution of fat in hips, thighs, breasts, and under the skin (subcutaneously). However, in excess and the absence of progesterone, oestrogen predisposes to unhealthy surplus weight gain in these tissues. Men generally have much lower levels of estradiol and higher testosterone, responsible for greater muscle mass and less fat distribution in areas of the body normally seen in women. In overweight men, testosterone levels drop, and oestrogens rise, leading to the same problematic weight gain in the hips, thighs, and breasts (referred to as gynecomastia) as seen in women.
Progesterone in addition to keeping oestrogen levels in check aids weight management by supporting thyroid metabolism, helping the body use and eliminate fats, and acting as a natural diuretic. In the proper ratios, progesterone and oestrogen help control how insulin is released and body fat stored. In addition, as the precursor of cortisol, progesterone supports adrenal regulation of blood glucose, while its natural calming properties may relieve stress-related overeating and food cravings.
Testosterone (T) And DHEAS (DS)
Testosterone and DHEA-S (DS) are androgens that increase lean muscle mass and metabolic rate. As androgen levels decline, muscle mass also decreases with a corresponding increase in adiposity. Low androgens can also reduce vitality and tolerance for exercise. Weight gain itself, with its resulting hormone imbalances, can trigger a drop in testosterone in men. The aromatase enzyme within fat tissue converts androgens to oestrogens, contributing to a female-type body fat distribution, including breast tissue development. In women with polycystic ovarian syndrome (PCOS), high testosterone and DHEA are linked to insulin resistance and weight gain, particularly in the abdomen.
Imbalances can create problems with blood sugar control, sleep patterns, appetite, food cravings, and exercise tolerance. Under stress, excessive cortisol production, particularly in concert with insulin, promotes fat storage in abdominal adipose tissue. This visceral type of fat is closely associated with insulin resistance and metabolic syndrome and, thus, more hazardous to health. In addition, chronically elevated cortisol is a known risk factor for pre-diabetes and cardiovascular disease.
Thyroid Stimulating Hormone (TSH)
Even within the high-normal range, TSH elevations are linked with hypothyroidism, low metabolic rate and obesity. Hypothyroidism is linked to elevated cortisol and can also be a consequence of oral oestrogen therapy, which increases the production of binding proteins that reduce thyroid hormone bioavailability.
Vitamin D (D2, D3)
Vitamin D deficiency is common in obesity and particularly associated with hyperinsulinemia and visceral fat. Whether by cause or effect, identifying and correcting vitamin D2 and D3 deficiency may improve insulin sensitivity.
Fasting Insulin (In)
When elevated, fasting insulin is a marker of insulin resistance that precedes metabolic syndrome, PCOS, and type 2 diabetes. Increased levels, particularly in concert with cortisol, lead to central obesity and increased inflammatory and other cardiovascular disease markers. Hyperinsulinemia also contributes to decreased testosterone levels in men but increased testosterone and decreased ovulation in women.
Haemoglobin A1C (HbA1c)
Haemoglobin is an indirect measure of the average circulating glucose levels over the previous three months. An HbA1c of more than 6% is predictive of type 2 diabetes and cardiovascular disease risk.
Total Cholesterol (CH)
The body requires cholesterol as a precursor to steroid hormone synthesis and as a component of cell membranes. However, in excessive amounts, it is a strong component of coronary heart disease risk because of its contribution to coronary atherosclerosis. Atherosclerotic plaque is largely composed of cholesterol. As with other risk factors, high blood cholesterol levels are more significant when other cardiometabolic parameters are already abnormal or in patients who already have diabetes or cardiovascular disease. The current National Cholesterol Education Program recommendations for total cholesterol levels are: <200 mg="" dl="borderline" 200="" -="" 239="" high="" data-mce-fragment="1">240 mg/dL = high.
High-Sensitivity C-Reactive Protein (hsCRP)
C-reactive protein (CRP) is an established marker of inflammation and has recently been suggested to be an important contributor to the pro-inflammatory and prothrombotic elements of cardiovascular disease (CVD) risk. Extremely high CRP levels are seen in acute inflammatory states, but the small elevations indicative of the pro-inflammatory and prothrombotic states implicated in the metabolic syndrome require high sensitivity assays and are thus referred to as hs-CRP levels. Levels below 3.0 mg/L are considered to be normal; 3.1—10 mg/L is elevated, in the context of CVD risk, and above 10 mg/ L is very high, more likely indicating an acute inflammatory event due to infection or trauma.
Triglycerides enter the circulation as the end-product of digesting dietary fat, and they are also synthesized by the liver. They are an important energy source for the body and are stored in fat cells. Elevated blood levels, or hypertriglyceridemia, often found in untreated diabetes and obesity, are an established indicator of atherogenic dyslipidemia. The National Cholesterol Education Program defines fasting triglyceride levels of 150 mg/dL or above as one of the diagnostic criteria for metabolic syndrome, although some studies have shown that fasting levels lower than 100 mg/dL should be considered as a more optimal cutoff in coronary heart disease risk assessment. The inflammatory state leading to the development of atherosclerosis may be triggered by “postprandial dysmetabolism,” a condition characterized by unusually high levels of glucose and triglycerides after a meal. Postprandial hypertriglyceridemia indicates the presence of remnant lipoproteins, which are believed to promote atherosclerosis, and it is also linked with insulin resistance and obesity. Several studies have found that triglyceride levels measured 2-4 hours after a meal are highly predictive of cardiovascular events, especially in women. Nonfasting levels >200 mg/dL are suggestive of postprandial dysmetabolism.
HDL Cholesterol (HDL)
Cholesterol bound to high-density lipoprotein (HDL) in the blood is known as HDL cholesterol. A low level of circulating HDL cholesterol is one of the established criteria for the diagnosis of metabolic syndrome and has long been regarded as a powerful predictor of cardiovascular disease in both diabetics and non-diabetics. In a large cohort from the Framingham Study, a high total cholesterol/HDL cholesterol or LDL cholesterol/HDL cholesterol ratio was associated with increased coronary heart disease risk, and a high HDL cholesterol level was associated with reduced risk, in both men and women. Currently, the LDL cholesterol/HDL cholesterol ratio is regarded as a reliable tool for the evaluation of cardiovascular disease risk. While absolute values of each are still considered by the National Cholesterol Education Program (NCEP) as the optimal diagnostic indicators, the ratios that doctors and researchers currently accept are as follows: total cholesterol: HDL cholesterol ratio – optimally below 4; LDL cholesterol: HDL cholesterol ratio – optimally below 3. The current NCEP recommendation to reduce the risk of cardiovascular disease is to maintain an HDL cholesterol level >40 mg/dL in both men and women.
Free Triiodothyronine (FT3)
It is the active form of thyroid hormone. Normal levels keep the body functioning properly and are crucial for maintaining physical and mental health.
Free Thyroxin (fT4)
It is the primary (inactive) thyroid hormone. However, a well-regulated process causes thyroxin to generate a much more potent thyroid hormone, T3 (Triiodothyronine).
Thyroid Peroxidase Antibody (TPO)
It is elevated with Hashimoto’s (autoimmune) thyroiditis and is associated with polycystic ovaries in women.
The Weight Management Profile allows providers to identify specific hormone imbalances associated with excess weight gain or obesity, vitamin D deficiency, and hypothyroidism in their patients. As a risk assessment panel, it allows for early detection of insulin resistance, metabolic syndrome, and type 2 diabetes. The comprehensive test report is designed to help clinicians recommend effective treatments to rebalance hormone levels, address vitamin D and thyroid deficiencies, reduce overall risk for metabolic syndrome, and potentially avoid type 2 diabetes.