Male Complete Saliva Hormone Profile
Concerned About Your Libido, Energy, Sleep or Physical Performance?
Low libido, persistent tiredness, disrupted sleep or changes in strength and motivation can leave you feeling unlike yourself.
The Male Complete Saliva Hormone Profile measures four sex and adrenal hormones alongside cortisol upon waking and before bed. This provides more information than a testosterone result alone and allows you to compare your cortisol level at the beginning and end of your waking day.
This test helps answer two practical questions:
How do my measured hormone levels compare with the laboratory ranges?
How does my cortisol level differ between morning and bedtime?
Your ZRT Laboratory report presents six individual results with reference ranges, visual graphs and hormone-specialist laboratory comments. These comments explain relevant findings and suggest useful next steps to consider.
- Six results from two saliva samples
- Measures five different hormones
- Includes testosterone and estradiol
- Compares morning and bedtime cortisol
- Collect at home without needles or a clinic appointment
- Hormone-specialist interpretation included
- Laboratory analysis included
- Normally reported within 3–5 working days after the laboratory receives your samples
Is This Test Right for Me?
This profile may be suitable if you want to explore concerns such as:
- Reduced libido or changes in sexual function
- Persistent tiredness or reduced stamina
- Difficulty becoming alert in the morning
- Poor sleep or difficulty winding down at night
- Reduced strength or disappointing exercise recovery
- Changes in body composition
- Low motivation, irritability or difficulty concentrating
- Changes in wellbeing during periods of sustained pressure
- Wanting more information than a testosterone result alone
It may also be useful if you want:
- A broader male hormone assessment
- Morning and bedtime cortisol measured alongside sex hormones
- A baseline for comparison with future tests
- Results to discuss with your healthcare professional
- Laboratory information to support a practitioner-led review of hormone treatment, where appropriate
These concerns can have several possible causes. This profile measures the listed hormones; it does not establish one definitive cause for tiredness, sexual symptoms, sleep problems or changes in physical performance.
What Will My Results Help Me Understand?
1. Review Your Testosterone Result
Your report shows the amount of testosterone measured in your saliva and compares it with the applicable laboratory range.
Benefit: You receive an objective measurement to consider alongside concerns about libido, energy, strength, motivation or physical wellbeing.
The result does not diagnose testosterone deficiency or replace a clinical assessment.
2. Consider Estradiol Alongside Testosterone
The profile measures estradiol as well as testosterone.
Benefit: You can review both results together rather than considering testosterone in isolation. This provides additional laboratory information for discussions about sexual wellbeing, body composition or breast tenderness.
The test does not determine the cause of an abnormal result or assess hormone conversion by itself.
3. Review Progesterone and DHEAS
Progesterone and DHEAS add further information about your measured steroid hormone profile.
Benefit: These results give your specialist more laboratory information to consider alongside testosterone, estradiol, your symptoms and any hormone treatment.
4. Compare Morning and Bedtime Cortisol
Cortisol is measured upon waking and again before bed.
Benefit: The two measurements show how your cortisol level differs between the beginning and end of your waking day. This may be useful when discussing morning tiredness, evening restlessness, difficulty winding down or disrupted sleep.
This is a two-point comparison. It does not provide the complete daily pattern shown by a four-point cortisol profile.
5. Decide What to Do Next
Your results are accompanied by individualised hormone-specialist laboratory comments.
Benefit: You receive an explanation of relevant findings rather than a set of unexplained numbers. Depending on your results and the information supplied on your requisition form, the comments may:
- Highlight results that deserve further discussion
- Consider relevant symptoms, medicines or hormone treatments
- Suggest practical areas to review with your healthcare professional
- Indicate whether additional testing may provide useful information
- Identify results that may be suitable for future comparison
What Will My Report Include?
Your ZRT Laboratory report includes:
- Your testosterone result
- Your estradiol result
- Your progesterone result
- Your DHEAS result
- Separate morning and bedtime cortisol results
- Laboratory reference ranges
- Visual graphs showing where your results fall
- Clear indicators for results outside the applicable ranges
- Your recorded sample-collection dates and times
- Relevant medicines and hormone treatments reported on your form
- Your reported symptoms, where applicable
- Individualised hormone-specialist laboratory comments
- Suggested considerations or next steps based on the findings
The specialist interpretation is included within your ZRT Laboratory report.
Providing complete information about your symptoms, medicines, supplements and hormone treatments helps make the laboratory comments more relevant to you.
What Does the Test Measure?
| Result | What it adds to your assessment |
|---|---|
| Testosterone | Provides a testosterone measurement to consider alongside concerns about sexual and physical wellbeing |
| Estradiol (E2) | Adds an oestrogen measurement to consider alongside testosterone |
| Progesterone | Provides further information about your measured steroid hormone profile |
| DHEAS | Measures an adrenal androgen involved in the production of other sex hormones |
| Morning cortisol | Shows your cortisol level at the beginning of your waking day |
| Bedtime cortisol | Allows comparison with your morning cortisol result |
The profile measures five different hormones and provides six individual results because cortisol is measured twice.
Saliva testing measures the unbound fraction of these hormones present in the samples. Saliva and blood tests measure hormones differently, so their results and reference ranges should not be used interchangeably.
Test Details
Test ID: S-145
Test panel: LCMS Hormones 5 with 2-Point Cortisol
Sample type: Saliva
Different hormones measured: 5
Results reported: 6
Samples required: 2 — upon waking and before bed
Testing method: LC-MS/MS
Laboratory: ZRT Laboratory — CLIA-certified
Hormone specialist interpretation: Included within the laboratory report
Suitable for: Adults and children able to provide the required saliva volume
Collection: At home — no clinic visit required
Laboratory reporting time: Normally 3–5 working days after the laboratory receives your samples
Kit validity: Use within 12 months of purchase
What Is Included?
Your purchase includes:
- At-home saliva collection kit
- One large morning collection tube
- One small bedtime collection tube
- Test Requisition Form
- Step-by-step collection instructions
- Laboratory analysis of six results
- Laboratory reference-range comparisons
- Visual result graphs
- Individualised hormone-specialist laboratory comments
- Suggested next steps or considerations
- Digital ZRT Laboratory report
- Laboratory analysis fee
Return postage to the laboratory is arranged and paid for separately by the customer.
How It Works
1. Choose Your Collection Day
Men and children can collect on any day. If you use hormone treatment, follow the treatment-specific timing instructions before choosing your collection day.
2. Collect Your Morning Sample
Begin collecting into the large 10 mL tube within 30 minutes of waking.
Do not eat, drink anything other than water or brush your teeth before collecting.
3. Collect Your Bedtime Sample
Collect into one small 5 mL tube before bed on the same day.
Avoid food, drinks other than water and toothbrushing for two hours before collecting.
4. Send Your Samples
Complete the Test Requisition Form and return both labelled samples using the supplied packaging and return instructions.
5. Receive Your Explained Results
Your report is normally issued by email within 3–5 working days after the laboratory receives your samples.
Kit delivery and return-postage time are separate from this laboratory reporting period.
Which Male Hormone Test Should I Choose?
| What do you want to understand? | Suggested test |
|---|---|
| Testosterone, estradiol, progesterone, DHEAS and one morning cortisol result | Male Saliva Hormone Profile I |
| The same five hormones, with cortisol compared upon waking and before bed | Male Complete Saliva Hormone Profile |
| Testosterone, estradiol and progesterone with cortisol measured at four points across the day | Male Saliva Hormone Profile II |
| Testosterone, estradiol, progesterone and DHEAS with a four-point daily cortisol profile | Comprehensive Male Saliva Hormone Profile |
Choose the Male Complete profile if you want the same core hormones as Profile I but would also benefit from comparing cortisol upon waking and before bed.
If your symptoms change at midday or during the afternoon, a four-point cortisol profile may provide more relevant information.
Preparing for Your Test
To help produce usable samples:
- Avoid anti-ageing or anti-wrinkle facial creams and biotin supplements for three days before collection.
- Record all medicines, supplements and hormone treatments on your Test Requisition Form.
- Collect the morning sample within 30 minutes of waking.
- Do not eat, drink anything other than water or brush your teeth before the morning sample.
- Avoid food, drinks other than water and toothbrushing for two hours before the bedtime sample.
- Rinse your mouth with water and wait five minutes before each collection.
- Fill each required tube at least halfway, excluding bubbles.
- Label both tubes with your name, collection date and collection time.
- Freeze the samples if they will not be posted within 24 hours.
If you use testosterone therapy, corticosteroids, troches or hormones dissolved under the tongue, follow the treatment-specific instructions before collecting. An alternative sample type may be recommended for some treatments.
Read the full Saliva Collection Instructions and follow the S-145 two-sample schedule.
Frequently Asked Questions
Does This Test Measure Five or Six Hormones?
It measures five different hormones:
- Testosterone
- Estradiol
- Progesterone
- DHEAS
- Cortisol
Cortisol is measured twice, so the report contains six individual results.
How Many Saliva Samples Do I Need?
Two samples collected on the same day:
- One in the large tube within 30 minutes of waking
- One in a small tube before bed
Your kit may contain additional tubes that are not required for S-145.
Does the Report Include Specialist Interpretation?
Yes. Hormone-specialist laboratory comments are included within your ZRT Laboratory report.
The comments explain relevant findings and may suggest points to discuss, practical areas to review or further assessment to consider. They are not a separate medical consultation.
How Does This Differ From Male Saliva Hormone Profile I?
Both profiles measure testosterone, estradiol, progesterone, DHEAS and morning cortisol.
The Male Complete profile adds a bedtime cortisol result, allowing comparison between the beginning and end of your waking day.
Does This Test Show My Complete Daily Cortisol Pattern?
No. It compares cortisol upon waking and before bed.
If you want to see how cortisol changes at four points from morning to bedtime, choose a profile containing a four-point cortisol assessment.
Will the Results Explain My Fatigue or Low Libido?
The results show whether the measured hormone levels fall within the applicable laboratory ranges and provide individualised laboratory comments.
This offers useful information, but fatigue and low libido can have several possible causes. The test does not establish that a particular hormone is responsible for your symptoms.
Can I Use This Test While Taking TRT?
It may be suitable depending on how your treatment is administered.
Continue prescribed treatment as directed, record all hormone use on the Test Requisition Form and follow the treatment-specific collection instructions. An alternative sample type may be recommended for troches or hormones taken under the tongue.
The results provide hormone measurements to discuss with your healthcare professional. They do not assess the safety or effectiveness of TRT by themselves.
Is the Test Suitable for Children?
Yes, provided the child can supply the required amount of saliva. Include their age, symptoms and reason for testing so the results can be considered appropriately.
How Quickly Will I Receive My Results?
The laboratory normally reports within 3–5 working days after receiving your samples. Kit delivery and return-postage times are additional.
Does the Price Include Laboratory Analysis?
Yes. The collection kit, laboratory analysis, digital report and hormone-specialist laboratory comments are included.
You are responsible for arranging and paying for return postage to the laboratory.
How Long Can I Keep the Kit?
Use the kit within 12 months of purchase.
Where Can I Find the Full Collection Instructions?
Download the Saliva Collection Instructions and follow the S-145 two-sample schedule.
Not Sure Whether This Is the Right Test?
Email info@hormonelab.co.uk with your age, main symptoms, medicines and current treatments. Our team will forward your enquiry to our specialist doctors and respond with a suggested testing option within 24 hours.
