Advanced Neurotransmitter Test Kit (LCMS) | Specialist Interpretation Included

Test ID: U-325 | Sample Type: Dried Urine (4 collections) | Technology: LC-MS | Results: 3–5 Working Days

Our lab (ZRT) is the only lab to offer a 24-hour equivalent in four easy collections — resulting in a more accurate assessment of individual neurochemistry.

The Advanced Neurotransmitter Test Kit is one of the most comprehensive at-home neurotransmitter tests available, measuring 26 neurotransmitters, metabolites, amino acid precursors, and related markers using advanced LC-MS (Liquid Chromatography Mass Spectrometry) technology.

Neurotransmitters are the chemical messengers that allow billions of nerve cells throughout the brain and nervous system to communicate with one another. They influence virtually every aspect of physical and mental wellbeing, including mood, stress response, motivation, concentration, memory, sleep quality, energy levels, emotional resilience, behaviour, and cognitive performance.

When neurotransmitters become imbalanced, the effects can extend far beyond mental health. Many individuals struggling with persistent fatigue, brain fog, anxiety, poor sleep, low motivation, mood swings, irritability, ADHD symptoms, or chronic stress may unknowingly have underlying neurochemical imbalances contributing to their symptoms.

This advanced neurotransmitter profile provides a detailed assessment of key neurotransmitter pathways, helping you and your healthcare practitioner gain a clearer understanding of how your nervous system may be functioning and identify areas that may benefit from personalised nutritional, lifestyle, or wellness interventions.

What Does the Neurotransmitters Test Measure?

Neuro Advanced Profile Includes:

Test Sample Report: Click to see >> Advanced Neurotransmitter Test Report

Collection Instructions: Click to see >> Saliva and Dried Urine Sample Collection Instructions

Why Is Neurotransmitter Testing Important?

Many symptoms associated with neurotransmitter imbalances can appear similar on the surface but may have very different underlying causes.

For example, two individuals may both experience anxiety, poor concentration, fatigue, and sleep disturbances. However, one person’s symptoms may be associated with elevated excitatory neurotransmitters such as glutamate, while another may have reduced inhibitory neurotransmitter activity involving GABA or altered serotonin metabolism.

Without testing, treatment strategies often rely on assumptions or trial-and-error approaches. Neurotransmitter testing provides objective data that may help identify patterns within the nervous system, allowing more informed decisions regarding diet, supplementation, lifestyle modifications, stress management, and other wellness strategies.

What Are Neurotransmitters?

Neurotransmitters are naturally occurring chemical messengers responsible for transmitting signals between nerve cells throughout the brain and body. They help regulate:

• Mood and emotional wellbeing
• Stress resilience
• Sleep quality
• Focus and concentration
• Memory and learning
• Motivation and reward pathways
• Energy production
• Behaviour and impulse control
• Cognitive performance
• Hormonal communication
• Nervous system regulation

Symptoms That May Be Associated With Neurotransmitter Imbalances

Neurotransmitter imbalances may be associated with symptoms such as:

• Anxiety and panic attacks
• Low mood or depression-related symptoms
• Brain fog and poor concentration
• ADHD symptoms and hyperactivity
• Memory difficulties
• Chronic fatigue and low motivation
• Mood swings, irritability, and emotional instability
• Insomnia and poor sleep quality
• Stress intolerance and impulsive behaviour
• OCD-related symptoms
• Low libido
• PMS and PMDD symptoms

While neurotransmitter testing is not intended to diagnose medical conditions, it can provide valuable information about neurochemical patterns that may contribute to these symptoms.

Why This Test Is Different

Many neurotransmitter tests focus only on measuring parent neurotransmitters. However, neurotransmitter activity is far more complex. Measuring neurotransmitters alone may not reveal whether they are being effectively metabolised, converted, or broken down within the body.

This advanced profile evaluates both neurotransmitters and their downstream metabolites, providing a more comprehensive view of neurotransmitter pathways and overall neurochemical balance. By examining these relationships, healthcare practitioners can often gain deeper insights than would be possible from neurotransmitter measurements alone.

The Relationship Between Neurotransmitters, Hormones and Stress

Hormones and neurotransmitters work closely together. Hormonal imbalances can influence neurotransmitter production and activity, while neurotransmitter imbalances can affect hormone signalling and stress responses. Many practitioners therefore choose to assess neurotransmitters alongside hormone testing to gain a broader understanding of a person’s overall health picture.

Click to see our Neurotransmitters and Hormone Tests

Advanced LC-MS Technology

This test uses Liquid Chromatography Mass Spectrometry (LC-MS), one of the most advanced analytical technologies available for biological testing. Benefits include high analytical sensitivity, excellent specificity, reliable measurement of multiple markers, and detailed neurochemical assessment with professional interpretation.

Convenient At-Home Collection

Unlike traditional 24-hour urine collections, this test uses four simple dried urine collections throughout the day. Non-invasive, no large containers, samples remain stable after drying, and can be returned by post. Suitable for adults and children.

How the Test Works

1. Order your kit — delivered directly to your door
2. Collect four dried urine samples at specific times during the day using the provided collection strips
3. Post your samples to the laboratory using the provided instructions
4. Receive your results by email within 3–5 working days of the lab receiving your samples

What You Receive With Your Results

• Graphical neurotransmitter results with individual marker values and reference ranges
• Metabolite analysis and neurotransmitter pathway assessment
• Specialist laboratory interpretation by a Hormone Specialist PhD Doctor
• Guidance on possible next steps
• Laboratory fee included — no hidden charges

Important Information

• Laboratory fee included — no hidden costs
• Customers are responsible for return shipping to the laboratory
• Test kit valid for 12 months from purchase date

About ZRT Laboratory

All testing is performed by ZRT Laboratory — a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries.

• Pioneers of at-home dried urine neurotransmitter and hormone testing
• Advanced LC-MS/MS technology for clinical-grade accuracy
• Qualified for the CDC Hormone Standardisation (HoSt) Program
• Rigorous internal and external quality assurance programmes

Hormone Lab UK (Testfield UK Ltd) is the official UK test provider for ZRT Laboratory. All samples are analysed by ZRT Laboratory, a CLIA-certified laboratory with over 25 years of experience in hormone, neurotransmitter, and wellness testing.

Frequently Asked Questions

What is a neurotransmitter test?

A neurotransmitter test measures key chemical messengers involved in communication between nerve cells throughout the brain and nervous system. This advanced test evaluates 26 neurotransmitter-related markers using dried urine samples collected throughout the day.

Why should I test my neurotransmitters?

Neurotransmitter imbalances may be associated with anxiety, low mood, brain fog, fatigue, poor concentration, sleep disturbances, ADHD-related symptoms, and reduced motivation. Testing provides objective information about your neurochemical profile and may help guide personalised wellness strategies.

Can neurotransmitter imbalances cause anxiety?

Research suggests that GABA, Glutamate, Serotonin, Norepinephrine, Histamine, and Dopamine all play important roles in regulating stress responses and emotional wellbeing. Imbalances in these pathways may be associated with anxiety-related symptoms in some individuals.

Is neurotransmitter testing useful for ADHD symptoms?

Neurotransmitters such as Dopamine, Norepinephrine, GABA, and Serotonin play important roles in attention, focus, motivation, and impulse control. While this test cannot diagnose ADHD, it may provide useful information regarding neurotransmitter patterns associated with attention and concentration challenges.

Can neurotransmitter imbalances affect sleep?

Yes. GABA, Glutamate, Serotonin, Histamine, Dopamine, and Norepinephrine are closely involved in sleep regulation and circadian rhythms. Imbalances may be associated with insomnia, difficulty falling asleep, or restless sleep.

Why are four samples collected during the day?

Neurotransmitter activity can fluctuate throughout the day. Collecting multiple samples provides a broader, 24-hour-equivalent assessment of neurochemical activity compared to a single spot sample — and ZRT is the only lab to offer this approach in four easy collections.

Why does this test measure neurotransmitter metabolites?

Metabolites help assess how neurotransmitters are being produced, converted, and broken down. This additional information provides a more comprehensive understanding of neurotransmitter function than measuring parent neurotransmitters alone.

Is this test suitable for children?

Yes. The dried urine collection method is non-invasive and suitable for adults and children.

Can neurotransmitter testing diagnose medical conditions?

No. This test is not intended to diagnose, treat, cure, or prevent any disease. It provides information about neurotransmitter-related biomarkers that may help support discussions with healthcare practitioners regarding symptoms and overall wellbeing.

Does the price include the laboratory fee?

Yes. The full laboratory analysis fee is included. There are no additional charges. You are responsible for posting your samples to the laboratory.

How long is the kit valid for?

The kit must be used within 12 months of the purchase date.

Related Neurotransmitter Test Panels

U-325 | LCMS Neurotransmitters
Trp, 5-HT, 5-HIAA, GABA, Gly, Tau, Glu, Gln, His, HIST, N-MeHist, PEA, Tyr, Tyra, DA, DOPAC, HVA, NE, NMN, Epi, VMA, Kyn, KynAc, 3OHKyn, Xanth, Crtn

U-321 | LCMS Diurnal Hormones I
FC(x4), FCn(x4), MT6s(x4), Crtn(x4)

U-322 | LCMS Diurnal Hormones II
FC(x4), FCn(x4), NE(x4), Epi(x4), MT6s(x4), Crtn(x4)

U-342 | LCMS Neurotransmitters and Diurnal Hormones I

U-343 | LCMS Neurotransmitters and LCMS Diurnal Hormones II

SU-843 | Saliva 4-Point Cortisol + Dried Urine LCMS Neurotransmitters

SU-840 | Saliva LCMS Hormones 7 + Dried Urine LCMS Neurotransmitters

SU-841 | Saliva LCMS Hormones 7 + Dried Urine LCMS Neurotransmitters and Diurnal Hormones I

SU-842 | Saliva LCMS Hormones 7 + Dried Urine LCMS Neurotransmitters and Diurnal Hormones II

SU-844 | Saliva LCMS Hormones 7 with 4-Point Cortisol + Dried Urine LCMS Neurotransmitters