Saliva 4-Point Cortisol + Dried Urine LCMS Neurotransmitters Test

Advanced Neurochemical & Stress Profile – At-Home Collection

A comprehensive assessment combining 4-point salivary cortisol testing with LC-MS dried urine neurotransmitter analysis, designed to evaluate stress patterns and full-spectrum neurotransmitter metabolism.

What This Test Measures

Cortisol Saliva – 4 Measurements

• Morning Cortisol (C)
• Noon Cortisol (C)
• Evening Cortisol (C)
• Bedtime Cortisol (C)

Total Saliva Measurements: 4

Neurotransmitters Urine Markers – 26 Measurements

• Tryptophan (Trp)
• Serotonin (5-HT)
• 5-Hydroxyindoleacetic Acid (5-HIAA)
• Gamma-Aminobutyric Acid (GABA)
• Glycine (Gly)
• Taurine (Tau)
• Glutamate (Glu)
• Glutamine (Gln)
• Histidine (His)
• Histamine (HIST)
• N-Methylhistamine (N-MeHist)
• Phenylethylamine (PEA)
• Tyrosine (Tyr)
• Tyramine (Tyra)
• Dopamine (DA)
• 3,4-Dihydroxyphenylacetic Acid (DOPAC)
• Homovanillic Acid (HVA)
• Norepinephrine (NE)
• Normetanephrine (NMN)
• Epinephrine (Epi)
• Vanillylmandelic Acid (VMA)
• Kynurenine (Kyn)
• Kynurenic Acid (KynAc)
• 3-Hydroxykynurenine (3OHKyn)
• Xanthurenate (Xanth)
• Creatinine (Crtn)

Total Urine Measurements: 26

Grand Total

• Saliva: 4
• Urine: 26

Total Measurements: 30 Tests

Why This Test Is Different

LC-MS Gold Standard Technology 

Liquid Chromatography–Mass Spectrometry (LCMS) offers:

• High sensitivity & specificity
• Extended linear range
• Reliable detection of complex metabolic pathways

Key Features

• Comprehensive Evaluation: The Neurotransmitter Test delivers an in-depth analysis of multiple neurotransmitters, providing a detailed overview of an individual’s neurochemical profile.
• Objective Measurement: The test offers quantitative, laboratory-based measurement of neurotransmitter levels, supporting clinical assessments with reliable and objective data.
• Personalised Treatment Planning: By identifying specific imbalances, healthcare professionals can design tailored treatment strategies. Recommendations may include targeted supplementation, medication support, nutritional adjustments, lifestyle changes, and other interventions aimed at restoring optimal balance.
• Diagnostic Support: The test assists in the evaluation of various neurological and mental health conditions by providing objective biochemical insights. It may help identify patterns associated with depression, anxiety, ADHD, and other related conditions.
• Targeted Therapeutic Guidance: Results highlight specific deficiencies or excesses, allowing interventions to focus directly on restoring neurotransmitter balance and improving overall well-being.
• Progress Monitoring: Testing can be repeated to track treatment effectiveness over time, enabling adjustments that optimise therapeutic outcomes.
• Differential Assessment: Since neurotransmitter imbalances may present with overlapping symptoms across conditions, the test supports clinicians in distinguishing contributing factors and refining diagnosis.
• Individualised Nutritional Recommendations: Identified imbalances can often be addressed through specific nutrient support. The results guide personalised nutritional strategies for optimal neurotransmitter function.
• Holistic Insight: The test supports a whole-person approach by recognising the interaction between neurochemistry, nutrition, lifestyle, and environmental influences.
• Suitable for All Ages: Appropriate for both adults and children.
• Non-Invasive Home Collection: Simple at-home sampling using four dried urine strips collected throughout the day, with easy storage and shipment.
• Reliable Laboratory Analysis: Accurate, timely, and dependable results from a certified laboratory.
• Comprehensive Metabolic Insight: Reports include evaluation of precursors, metabolites, enzymes, and cofactors, offering guidance for targeted therapeutic planning.
• Detailed Clinical Report: A personalised, literature-referenced report explains results clearly and outlines treatment considerations prepared by specialist PhD-level scientists.
• Free UK Delivery: Complimentary shipping of the test kit within the United Kingdom.
• Shipping Responsibility: Customers are responsible for sending their samples to the laboratory.
• All-Inclusive Laboratory Fee: The test kit price includes the full laboratory analysis fee with no additional lab charges or taxes.
• Advanced Report Access: Click to view the >> Advanced Neurotransmitter Test Report
• Validity Period: The kit must be used within 12 months from the purchase date.
• Fast Turnaround: Results are delivered via email within 3–5 working days after the laboratory receives the sample. The report includes clear graphical and numerical presentations of neurotransmitter levels, along with specialist commentary and guidance on next steps where imbalances are identified.

Who Is This Test For?

You may benefit if you experience:

• Anxiety or depression
• Mood swings
• Insomnia or poor sleep
• Fatigue
• ADHD / focus issues
• Panic attacks
• PMS or PMDD
• Low libido
• Brain fog
• Impulsivity
• Chronic stress

If you regularly experience 3 or more of these symptoms, neurotransmitter imbalance may be contributing.

Why Test Neurotransmitters?

Neurotransmitters regulate:

• Mood & emotional stability
• Sleep–wake cycles
• Motivation & reward pathways
• Memory & cognitive performance
• Pain perception
• Appetite regulation
• Autonomic functions (heart rate, digestion, blood pressure)

Imbalances can contribute to:

• Anxiety & depression
• ADHD & OCD
• Chronic fatigue
• Sleep disorders
• PMS / PMDD
• Neurological conditions
• Treatment-resistant mood disorders

Testing provides an objective foundation beyond symptom-based evaluation.

Clinical Benefits

1. Personalised Treatment Strategy. Identify specific imbalances and guide:

• Targeted nutrient supplementation
• Lifestyle optimisation
• Medication selection
• Functional medicine protocols

2. Diagnostic Support. Assist in differential diagnosis of:

• Depression
• Anxiety disorders
• ADHD
• Mood instability

3. Monitor Treatment Progress. Retesting allows:

• Objective tracking
• Adjustment of interventions
• Optimisation of therapeutic outcomes

4. Holistic Nervous System Assessment. Recognises interplay between:

• Brain chemistry
• Hormones
• Gut axis
• Stress physiology

Cortisol + Neurotransmitters: Why Combine Them?

Chronic stress alters neurotransmitter balance. 4-point cortisol testing helps assess:

• Morning activation
• Afternoon energy stability
• Evening wind-down
• Overall HPA axis resilience

Combined testing provides a deeper understanding of:

• Stress-induced neurochemical changes
• Burnout patterns
• Adrenal–neurotransmitter interactions

How the Test Works

At-Home Collection

• 4 saliva samples (specific times)
• 4 dried urine strips throughout the day
• Simple instructions included

Your Report Includes

• Graphical and numerical results
• Interpretation comments from Specialist PhD Dr.
• Clinical guidance suggestions
• Clear explanation of imbalances
• Click to view the >> Advanced Neurotransmitter Test Report

Test Kit Includes

• Test requisition form with symptom checklist
• Medical history form
• Detailed collection instructions
• Dried urine collection cards
• Saliva collection materials
• Return envelope
• Shipping instructions

The test must be used within 12 months of purchase.

Important Considerations

• Assumes normal kidney function
• Not suitable for individuals with compromised renal function
• On test day: avoid alcohol, nicotine, bananas, pineapple, walnuts
• Maintain normal fluid intake (avoid excessive drinking)
  
• Detailed sample collections instructions provided with the test kit

A Functional View of Brain Health

Urinary neurotransmitter testing does not directly measure brain neurotransmitters, but reflects systemic neurotransmitter tone and metabolic regulation. Clinical research supports its role in guiding targeted interventions and monitoring therapeutic outcomes.

When neurochemistry becomes unbalanced, symptoms may appear long before conventional diagnostics detect abnormalities. Objective testing provides clarity.

Suitable For

• Adults
• Children
• Individuals seeking personalised brain health optimisation
• Patients under practitioner supervision

Free UK Delivery | Laboratory Fee Included | No Additional Costs

Take control of your neurochemistry with advanced, clinically validated testing.