Test ID: S-123
The Essential Female Hormone Saliva Profile is an advanced at-home hormone test designed specifically for women, accurately measuring three core sex hormones — Oestrogen-Estradiol (E2), Progesterone (Pg), and Testosterone (T) — using gold-standard LCMS (Liquid Chromatography–Mass Spectrometry) laboratory technology.
These three hormones work in concert to regulate the menstrual cycle, fertility, mood, energy, libido, sleep, and long-term health. When their balance is disrupted — as commonly happens during the perimenopause, after stopping the pill, following pregnancy, or due to chronic stress — the impact can be wide-ranging and deeply disruptive. This test gives you a precise, evidence-based snapshot of where your hormones stand, interpreted by a specialist doctor.
Test from home with confidence — no clinic visit required.
Why Choose LCMS Hormone Testing?
Unlike standard immunoassay methods, LCMS offers higher sensitivity and specificity, accurate measurement of active (bioavailable) hormones in saliva, reliable results for complex hormonal patterns — particularly important across different phases of the menstrual cycle — and greater precision for monitoring hormone therapy including HRT and bioidentical hormones. LCMS is considered the gold standard for advanced hormone analysis.
What This Test Measures
Estradiol (E2)
The dominant and most potent form of oestrogen in premenopausal women. Estradiol drives the menstrual cycle, supports ovulation and fertility, maintains bone density, promotes skin elasticity and collagen production, regulates mood and serotonin activity, and protects cardiovascular health. Declining estradiol is the primary driver of perimenopause and menopause symptoms — including hot flushes, night sweats, vaginal dryness, brain fog, and low mood.
Progesterone (Pg)
Produced primarily after ovulation, progesterone is the essential counterbalance to oestrogen. It regulates the second half of the menstrual cycle, supports implantation and early pregnancy, promotes calm, sleep quality, and emotional resilience, and protects against oestrogen dominance. Low progesterone is one of the most common hormonal imbalances in women — linked to PMS, anxiety, insomnia, heavy periods, and difficulty conceiving. Progesterone declines significantly in perimenopause, often years before oestrogen does.
Testosterone (T)
Often overlooked in women, testosterone is essential for libido and sexual responsiveness, energy and physical vitality, muscle tone and body composition, motivation, confidence, and cognitive sharpness. Low testosterone in women is associated with persistent fatigue, flat mood, reduced sex drive, and difficulty maintaining lean muscle — and becomes increasingly common after 35 and during perimenopause.
Who Should Consider This Test?
This saliva hormone profile is particularly relevant for women who experience:
- Irregular, heavy, or painful periods
- PMS — mood swings, bloating, breast tenderness, irritability
- Perimenopausal or menopausal symptoms — hot flushes, night sweats, brain fog, low mood
- Low libido or reduced sexual responsiveness
- Persistent fatigue or low energy despite adequate sleep
- Anxiety, depression, or emotional instability
- Difficulty sleeping or waking in the night
- Weight gain or difficulty losing weight, especially around the middle
- Fertility concerns or difficulty conceiving
- Symptoms of oestrogen dominance — bloating, breast tenderness, heavy bleeding
- Wanting to monitor HRT or bioidentical hormone therapy
- Feeling "off" hormonally but told results are "normal" on standard tests
How the Test Works
- Order your kit securely online.
- Collect your saliva samples at home following the detailed instructions — ideally timed to the appropriate phase of your menstrual cycle (guidance included).
- Post your samples to the laboratory.
- Receive your comprehensive digital report within 3–5 working days of lab receipt.
- Review your results, including specialist interpretation and clear next-step guidance.
What Your Report Includes
- Measured levels of Estradiol, Progesterone, and Testosterone
- Laboratory reference ranges appropriate for your life stage
- Easy-to-read graphical presentation
- Specialist commentary written by a Hormone Specialist PhD Doctor
- Practical next-step recommendations
Frequently Asked Questions
What hormones are included?
Estradiol (E2), Progesterone (Pg), and Testosterone (T).
When should I collect my sample?
For cycling women, Day 19–21 of your cycle (7 days after ovulation) is optimal for capturing both oestrogen and progesterone. Full guidance is included in the kit.
Can I use this test if I am postmenopausal or on HRT?
Yes. This test is suitable for women at all life stages, including those on HRT, bioidentical hormones, or the contraceptive pill.
How long until I receive results?
Results are delivered within 3–5 working days after laboratory receipt.
Is professional interpretation included?
Yes. Each report includes specialist commentary from a Hormone Specialist PhD Doctor.
How long is the kit valid?
12 months from purchase.
Who pays for shipping?
You are responsible for posting your samples to the laboratory.
Why We Partner with ZRT Laboratory
Founded in 1998 by renowned biochemist and breast cancer researcher Dr. David Zava, PhD, ZRT Laboratory is a globally recognised, CLIA-certified diagnostic laboratory specialising in hormone, thyroid, fertility, adrenal, neurotransmitter, cardiometabolic, heavy metals, and wellness testing.
Having performed more than 11 million laboratory tests and trusted by healthcare professionals in over 96 countries, ZRT is recognised for scientific excellence, innovation, and analytical accuracy. The laboratory pioneered at-home saliva hormone testing, was the first to commercialise dried blood spot (DBS) hormone testing, and developed Dried Urine Testing (DUTS), making advanced laboratory diagnostics more accessible and convenient.
Using state-of-the-art LC-MS/MS and ICP-MS technology, together with rigorous quality standards and ongoing scientific research, ZRT delivers highly accurate, clinically reliable results. Its commitment to innovation, physician-reviewed reference ranges, and collaboration with organisations including the CDC, NIH, and leading universities has established ZRT as one of the world’s most trusted names in hormone and functional laboratory testing.
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