Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — testosterone

Written By Dr Allison McAllister It’s an everyday occurrence when someone calls the doc line at the lab and wants to know how they can change the labs to improve their patients’ symptoms. However, it’s important to take a step back and look at what labs can tell us. While it’s true that abnormal lab findings can contribute to symptoms – high thyroid-stimulating hormone reflects hypothyroidism, high testosterone reflects polycystic ovary syndrome, and hyperandrogenism or low cortisol may contribute to fatigue. Yet, in many other conditions, labs reflect the medical condition happening in that patient’s body and not a cause...

By David Zava, ZRT Laboratory Delivery of the bioidentical hormones estradiol (E2), progesterone (Pg), and testosterone (T) through the skin as a cream or gel (topically) has become a mainstay of bioidentical hormone replacement therapy (BHRT) for women and men. A plethora of FDA-approved pharmaceuticals, compounded, and even over-the-counter topical BHRT products are available. The popularity of these products lies not only in their ease of use but in proven clinical efficacy [1-5] in treating hormonal deficiencies mostly brought on by ageing of the female (menopause) and male (andropause) reproductive systems. Dosing for Optimal Clinical Benefit Over the past 30 or so...

Low testosterone in older men, often referred to as “male menopause” or even “andropause” is fairly well known — and testosterone replacement therapy in this age group has not been without its share of controversy, particularly with respect to heart health. Proper testing and dosing are all-important, as well as understanding a man’s physiology and all the factors that affect testosterone levels. For example, when giving testosterone transdermally it is critical to use testing methods such as dried blood spot or saliva to properly assess absorption of testosterone into the body, avoiding the problem of overdosing to achieve “normal” serum levels. But while...

The relationship between testosterone therapy and cardiovascular risk in men is one of the most debated topics in men's health. Headlines have warned of increased heart attack risk, yet the research tells a more nuanced story. Age, pre-existing cardiovascular disease, oestrogen levels, dosage, and delivery method all appear to play significant roles. This article examines the key findings from a major insurance-data study, explores the clinical questions it raises, and explains what men and their doctors should consider before starting or continuing testosterone therapy.

By Dr. Allison Smith, ZRT Laboratory Sex Hormone Binding Globulin (SHBG) is one of the most overlooked variables in hormone health. It directly controls how much testosterone is biologically active in your body — yet it rarely appears on standard blood panels. Whether you're dealing with symptoms of low testosterone, androgen excess, or unexplained hormonal imbalance, understanding SHBG is essential to getting the full picture. What is SHBG? SHBG is a protein produced primarily in the liver that binds tightly to testosterone — and to a lesser degree, oestradiol (E2) and dihydrotestosterone (DHT) — and carries them through the bloodstream....