Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — menopause

Hot flashes, mood instability, brain fog and memory changes during perimenopause are not “all in your head” — but they are very much in your brain. In this in-depth clinical article, Dr. Kate Placzek of ZRT Laboratory explains how declining estradiol disrupts brain glucose metabolism, neurotransmitter signalling and thermoregulation, why perimenopause represents a window of neurological vulnerability, and why the timing of hormone replacement therapy is critical to protecting long-term brain health.

Hot flushes, night sweats, anxiety, insomnia and brain fog — menopause can feel overwhelming. But what is actually happening biochemically? In this case study, Dr. Kate Placzek and Dr. Allison Smith walk through the test results of Julia, a newly postmenopausal woman, showing exactly how hormone and neurotransmitter imbalances drive menopausal symptoms — and what can be done about it.

In perimenopause, falling estradiol doesn’t just trigger hot flashes — it disrupts serotonin production, driving mood swings, brain fog and sleepless nights. Discover the hormonal science behind “the change” and how testing can help.

The Women’s Health Initiative (WHI) trial cast a long shadow over hormone replacement therapy — but it enrolled women well over a decade past menopause. Two newer trials, ELITE and KEEPS, specifically studied HRT started early in the postmenopausal period. Their findings on cardiovascular health, sexual function, sleep, mood and cognition paint a more nuanced and encouraging picture. Here is what the latest research shows.

Breast cancer is not one disease — it encompasses many distinct types with different attributes, degrees of invasiveness and treatment responses. Understanding the difference between invasive and non-invasive cancers, what hormone receptor status means, and which risk factors are modifiable can help women make more informed decisions about screening, lifestyle and hormone health. This article provides a clear, evidence-based overview.