Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — long term wellness

What is Cardiometabolic Risk? Cardiometabolic risk refers to a collection of conditions linked to obesity and insulin resistance that increase the chances of developing type 2 diabetes, heart disease, or both. These risks rarely occur in isolation—when one appears, others often follow. That’s why proactive screening is so important.

Single nucleotide variations (SNVs) in the enzymes that metabolise estrogen can significantly alter breast cancer risk — in some cases by as much as 12-fold when multiple variants combine. In this detailed scientific overview, Jillian Harrington PhD of ZRT Laboratory explains how variations in CYP11A1, CYP19A1 (aromatase), CYP1B1, COMT and MnSOD affect the estrogen metabolism pathway, why catechol estrogens are dangerous, and how methylation testing can reveal individual vulnerability.