Blog — HRT

Perimenopause, also known as the menopausal transition, is a natural and normal part of a woman's life. It refers to the years leading up to menopause, which is defined as the point at which a woman has not had a menstrual period for 12 consecutive months. Perimenopause typically begins in a woman's 40s but can start as early as the mid-30s. During perimenopause, the body's production of estrogen and progesterone, two hormones essential to a woman's reproductive system, begins to decline. This decline can cause a range of symptoms, including hot flashes, night sweats, mood swings, sleep disturbances, vaginal dryness,...

One of the primary objectives of the Women's Health Initiative was to see if postmenopausal hormone replacement therapy (HRT) improved long-term risk of coronary heart disease, among other chronic diseases. However, the combined estrogen/progestin (Prempro) arm was halted in 2002, citing that the participants’ risk of cardiovascular disease outweighed any potential benefit of HRT in the prevention of colorectal cancer and bone fracture [1]. The conjugated equine estrogen (CEE)-only arm was also halted in 2004 citing no improvement in heart disease risk but an increased incidence of stroke, and no benefit in terms of fractures, although there was a reduced breast...