Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — Depression

  By Dr. Tracy Tranchitella, ND (ZRT Laboratory) The Cortisol Awakening Response (CAR) is the predictable rise in cortisol within the first hour of awakening. There are two events that contribute to this dynamic rise in morning cortisol. The first is in response to adrenocorticotropic hormone output from the pituitary as a part of the normal circadian activities of the hypothalamic–pituitary–adrenal (HPA) axis with involvement from the sympathetic nervous system. The second occurs in response to exposure to daylight with the activation of the suprachiasmatic nucleus in the hypothalamus, which happens within 30-45 minutes after awakening and can increase cortisol...

A growing body of research suggests that mitochondrial dysfunction may lie at the root of many treatment-resistant mental health conditions — including depression, anxiety, bipolar disorder, OCD and even dementia. In this clinical overview, Dr. Peter Bongiorno explains why neurons are particularly vulnerable to mitochondrial damage, how stress, heavy metals and hormonal imbalances compound the problem, and what a comprehensive 5-step repair plan looks like in practice.

The contraceptive pill is one of the most widely used medications in the world — but its effects on mood, brain chemistry and hormone balance are still poorly understood. This article explores how synthetic hormones disrupt oestrogen, progesterone, cortisol and neurotransmitters, and why some women are far more vulnerable to depression and anxiety as a result.

Hormonal contraception suppresses ovarian function, which means saliva and blood spot hormone test results will appear artificially low — but this doesn’t mean hormone levels at the tissue level are low. This guide explains how to interpret hormone test results correctly when using the pill, patch, ring or IUD, and when to collect your sample for the most meaningful data.

Hot flashes and night sweats affect up to 80% of women during perimenopause — but they are not inevitable, and they are not forever. The root cause is hormonal imbalance, particularly the out-of-sync fluctuation of oestrogen and progesterone as the ovaries begin to wind down. Discover the lifestyle changes, natural supplements and hormone testing strategies that can bring real relief.