Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — brain health

Neurotransmitters like dopamine, serotonin, and GABA control mood, sleep, focus, and energy. When they fall out of balance, the effects can be wide-ranging — and testing is the first step to understanding why.

  The human body is a complex and interconnected system, and nowhere is this more evident than in the intricate dance between our physical health and mental well-being. At the heart of this connection lies a network of chemical messengers known as neurotransmitters, playing a crucial role in transmitting signals between nerve cells. Understanding the levels of these neurotransmitters can be pivotal in unravelling the mysteries of various mental health conditions and shedding light on the intricate balance of our biochemistry. The Neurotransmitter Test: Peering Into the Mind's Chemistry Enter the neurotransmitter test, a cutting-edge screening tool designed to provide...

By Dr.David Zava, ZRT Laboratory Topical Progesterone, Not Synthetic Progestins or Oral Progesterone, Should Be Considered as a Companion for Estradiol Replacement Therapy In 2002 several large-scale clinical studies were published on the risks of breast cancer in postmenopausal women using conventional FDA-approved hormone therapy. These were the Women’s Health Initiative (WHI) and Million Women’s studies of women using FDA-approved estrogens and progestogens in the United States and Great Britain, respectively [1,2]. Both studies came to the same conclusion – that estrogen therapy, mostly in the form of oral conjugated equine estrogens, by itself did not significantly increase the risk of...

A growing body of research suggests that mitochondrial dysfunction may lie at the root of many treatment-resistant mental health conditions — including depression, anxiety, bipolar disorder, OCD and even dementia. In this clinical overview, Dr. Peter Bongiorno explains why neurons are particularly vulnerable to mitochondrial damage, how stress, heavy metals and hormonal imbalances compound the problem, and what a comprehensive 5-step repair plan looks like in practice.

Perimenopause is far more than a reproductive transition — it is fundamentally neurological. As oestradiol declines, the brain’s bioenergetic system becomes compromised, neurotransmitter balance shifts, and the thermoneutral zone narrows, giving rise to hot flashes, mood instability, memory changes and sleep disruption. This article explores the neuroscience behind the menopausal transition and why hormone replacement therapy — timed correctly — may be the most effective intervention.