Test ID: S-142 | Sample Type: Saliva | Technology: LC-MS/MS | Results Time: 3–5 Working Days After Laboratory Receives Sample | Laboratory: ZRT Laboratory – CLIA Certified | Hormone Specialist Doctor Interpretation: Included | Suitable For: Adults and Children | Collect Sample At Home: No Clinic Visit Required
What Does This Test Measure?
Saliva — Advanced Female Hormone Panel (LC-MS/MS): Estrone (E1), Estradiol (E2), Estriol (E3), Progesterone, Testosterone, DHEAS, Morning Cortisol, Noon Cortisol, Evening Cortisol, Night Cortisol.
10 markers — the most comprehensive female saliva hormone panel available: combining the full oestrogen triad, progesterone balance, androgen sufficiency, adrenal reserve, and a complete 4-point diurnal cortisol curve in a single at-home kit.
Related Symptoms
Irregular, heavy, or painful periods, PMS including mood swings, bloating or breast tenderness, perimenopausal or menopausal symptoms including hot flushes and night sweats, low libido, persistent fatigue or low energy despite adequate sleep, anxiety or emotional instability, poor sleep quality or night waking, afternoon energy crashes, evening anxiety or racing thoughts, weight gain particularly around the abdomen, fertility concerns, burnout or chronic stress, or feeling hormonally off despite normal standard blood test results.
Did You Know?
No standard GP blood panel measures all three oestrogens, free testosterone, DHEAS, progesterone, and the full daily cortisol curve simultaneously. This profile is the only way to assess in a single test whether oestrogen dominance is adipose-driven (elevated E1 relative to E2), whether the estriol-to-estradiol ratio indicates a more proliferative oestrogenic environment, whether cortisol at each of the four daily time points is suppressing progesterone via pregnenolone steal, whether DHEAS depletion is reducing androgenic and oestrogenic precursor availability, and whether the full HPA axis pattern is compounding perimenopausal or postmenopausal symptoms beyond the ovarian contribution alone. Each mechanism requires a distinct clinical response — and this panel identifies which are active.
Who Should Consider This Test?
- Irregular, heavy, or painful periods
- PMS — mood swings, bloating, breast tenderness, or irritability
- Perimenopausal or menopausal symptoms — hot flushes, night sweats, brain fog, or low mood
- Low libido or reduced sexual responsiveness
- Persistent fatigue or low energy despite adequate sleep
- Anxiety, depression, or emotional instability
- Difficulty sleeping, night waking, or insomnia
- Afternoon energy crashes or mid-day fatigue
- Evening anxiety, restlessness, or difficulty switching off
- Weight gain or difficulty losing weight, especially around the abdomen
- Fertility concerns or difficulty conceiving
- Postmenopausal women wanting the most complete oestrogenic status assessment
- Burnout, chronic stress, or emotional exhaustion
- Currently on HRT or bioidentical hormones and wanting a complete oestrogen triad alongside the full cortisol rhythm
- Feeling hormonally off but told results are normal on standard blood tests
Why This Test Is Particularly Important for Women
- The full oestrogen triad (E1, E2, E3) reveals oestrogenic source and metabolic balance — elevated estrone relative to estradiol indicates adipose-driven aromatisation; a low estriol-to-estradiol ratio indicates a more proliferative oestrogenic environment; these patterns guide HRT selection, progesterone dosing, and lifestyle prioritisation in a way that E2 measurement alone cannot
- The 4-point cortisol curve reveals how HPA axis function shapes reproductive hormone balance across the full day — elevated noon cortisol suppresses afternoon progesterone; elevated evening cortisol prevents the progesterone rise supporting luteal phase stability and sleep; elevated night cortisol drives insomnia and night sweats frequently misattributed to oestrogen deficiency alone
- DHEAS is the adrenal precursor to both oestrogen and testosterone in women — combined with the full cortisol curve, it reveals whether cortisol-mediated DHEAS suppression is contributing to sex hormone decline independently of ovarian function
- The progesterone-to-estradiol ratio is the most clinically meaningful number in this panel — oestrogen dominance drives the majority of PMS, cycle irregularity, breast tenderness, and perimenopausal anxiety even when absolute estradiol appears within range
- Testosterone deficiency in women is systematically overlooked — combined with the cortisol and DHEAS picture, it reveals whether adrenal depletion is the primary driver of androgenic insufficiency rather than ovarian decline
Not Sure Which Test Is Right for You?
Email us at info@hormonelab.co.uk with your gender, age, symptoms, medications, and any current treatments. We will forward your enquiry to our doctors and respond within 24 hours.
How It Works
- Order your kit — delivered directly to your door
- Collect four saliva samples across the day — morning (ideally 6–8am, within 30 minutes of waking), noon, evening, and night — following the detailed instructions; guidance on optimal cycle timing is included
- Post your samples to ZRT Laboratory using the return instructions provided
- Receive your full report by email within 3–5 working days
What You Receive
- Estrone (E1), Estradiol (E2), Estriol (E3), Progesterone, Testosterone, DHEAS, and 4-point Cortisol results with female life-stage-specific reference ranges
- Full diurnal cortisol curve graph and oestrogen triad chart
- Full oestrogen triad ratio analysis, progesterone-to-estradiol assessment, cortisol–progesterone interaction, and adrenal–sex hormone evaluation by a Hormone Specialist PhD Doctor
- Personalised next-step recommendations
- Laboratory fee included — no hidden charges
Why We Use ZRT Laboratory
All testing is performed by ZRT Laboratory — a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries.
- Pioneers of at-home dried blood spot (DBS) and saliva hormone testing
- Advanced LC-MS/MS technology for clinical-grade accuracy
- Qualified for the CDC Hormone Standardization (HoSt) Program
- Personalised reference ranges based on age and sex
Through our partnership with ZRT Laboratory, Hormone Lab UK delivers internationally recognised, research-backed hormone testing to people across the UK and Europe — from the comfort of home.
Frequently Asked Questions
What hormones does this test measure?
Estrone (E1), Estradiol (E2), Estriol (E3), Progesterone, Testosterone, DHEAS, and Cortisol at four time points (morning, noon, evening, night) — 10 markers covering the complete female hormonal and HPA axis picture.
When should I collect my samples during my menstrual cycle?
Day 19–21 of your cycle (approximately 7 days after ovulation) is optimal for capturing progesterone and estradiol in context. Full timing guidance for irregular cycles, perimenopause, postmenopause, and HRT users is included in your kit.
Can I use this test if I am postmenopausal or on HRT?
Yes. This is the most complete panel available for postmenopausal women and those on HRT, providing the full oestrogen triad, DHEAS adrenal reserve, and the complete cortisol rhythm alongside sex hormones — everything needed to guide therapy decisions and identify residual symptom drivers.
How does this differ from Female Saliva Hormone Profile III?
Profile III measures the full oestrogen triad, progesterone, testosterone, DHEAS, and morning cortisol — 7 markers at a single morning time point. The Advanced Profile extends this with a full 4-point diurnal cortisol curve — providing complete visibility of how cortisol behaves throughout the day and its interaction with progesterone, estradiol, and adrenal regulation.
Does the price include the laboratory fee?
Yes. The full laboratory analysis fee is included. There are no additional charges. You are only responsible for posting your samples to the laboratory.
How long is the kit valid for?
The kit must be used within 12 months of the purchase date.
