Female Hormone & Thyroid Test | Specialist Doctor Report Included

Test ID: SB-647 | Saliva LCMS Hormones 7 + Blood Spot Thyroid Panel

The Female Hormone & Thyroid Test is the most comprehensive at-home hormone and thyroid profile available for women, measuring 13 key hormones and markers — 7 sex and stress hormones via saliva LCMS and a full 6-marker thyroid panel via blood spot. It is designed to identify the hormonal root causes behind the symptoms that affect women most: persistent fatigue, weight gain, mood changes, poor sleep, cycle irregularities, and perimenopausal or menopausal symptoms.

What makes this test uniquely valuable is the combination it offers. The female sex hormone panel — including all three forms of oestrogen — reveals not just whether hormones are high or low, but how they are interacting, converting, and balancing against each other. The full thyroid panel identifies whether thyroid dysfunction, autoimmune thyroid disease, or cortisol-driven T3 suppression is compounding hormonal symptoms. And the 4-point cortisol reading shows how adrenal function is affecting both thyroid conversion and the sex hormone balance throughout the day.

No single test provides more clinically relevant information for a woman trying to understand her hormonal health.

Test from home with confidence — no clinic visit required. Results within 3–5 working days.

Why This Test Is Uniquely Suited to Women

The female hormonal system is not a collection of independent hormones — it is a tightly integrated network in which every marker affects every other. This test measures the full network:

• All three oestrogens together reveal the full picture — oestradiol (E2) is the dominant premenopausal oestrogen but declines sharply in perimenopause; oestriol (E3) rises during pregnancy and reflects oestrogenic tissue activity; oestrone (E1) becomes the dominant oestrogen after menopause and drives oestrogen-dominant symptoms in postmenopausal women; measuring all three reveals oestrogen metabolism, dominance, and conversion patterns that E2 alone cannot show
• Progesterone is the essential counterbalance to oestrogen — low progesterone relative to oestrogen (oestrogen dominance) is one of the most common hormonal patterns in women and drives PMS, heavy periods, breast tenderness, anxiety, insomnia, and weight gain; it is directly caused by stress, cortisol excess, anovulation, and perimenopause
• Testosterone in women is critical for energy, libido, and mood — low testosterone is associated with persistent fatigue, low motivation, reduced libido, and poor exercise tolerance; elevated testosterone (as in PCOS) drives acne, hair loss, and cycle irregularities
• DHEAS is the adrenal androgen precursor — declining DHEAS in women accelerates from the mid-30s and is directly linked to fatigue, low libido, worsening perimenopausal symptoms, and poor stress resilience; it is also the missing piece when testosterone appears normal but androgen-related symptoms persist
• Cortisol suppresses progesterone and T3 conversion simultaneously — chronic stress is one of the most common causes of progesterone deficiency, oestrogen dominance, and hypothyroid-like symptoms in women; testing cortisol alongside sex hormones and thyroid markers reveals the full stress-hormone cascade
• The full thyroid panel catches what TSH alone misses — in women, oestrogen affects thyroid-binding globulin; cortisol suppresses T4-to-T3 conversion; and Hashimoto’s thyroiditis (detected by TPO and Tg antibodies) can be present for years before TSH becomes abnormal; FT3, FT4, TT4, and both antibodies are all required for a complete assessment

What This Test Measures

Saliva — 7 Sex & Stress Hormones (LCMS)

• Oestradiol (E2): The primary and most potent oestrogen in premenopausal women. Drives reproductive function, bone density, cardiovascular protection, collagen production, and mood stability. Declining E2 in perimenopause triggers hot flushes, night sweats, vaginal dryness, low mood, and accelerated bone loss.
• Oestriol (E3): The weakest of the three oestrogens, produced primarily during pregnancy but also present in non-pregnant women as a product of oestrogen metabolism. E3 levels reflect oestrogenic tissue activity and oestrogen conversion pathways; lower E3 relative to E1 and E2 can indicate suboptimal oestrogen metabolism.
• Oestrone (E1): The dominant oestrogen after menopause, produced by the conversion of androgens in adipose tissue. Elevated E1 in postmenopausal women — particularly those who are overweight or on HRT — can drive oestrogen-dominant symptoms including breast tenderness, bloating, and increased cancer risk if not balanced by progesterone.
• Progesterone (Pg): The essential counterbalance to oestrogen in women. Progesterone supports sleep, mood, bone health, and uterine integrity; it is a natural cortisol inhibitor, anti-inflammatory agent, and thyroid function supporter. Low progesterone — caused by anovulation, chronic stress, perimenopause, or luteal phase deficiency — is one of the most common and most overlooked causes of female hormonal symptoms.
• Testosterone (T): Present in women in small but critical amounts. Essential for libido, energy, muscle tone, motivation, and cognitive clarity. Both low testosterone (associated with fatigue, low libido, and depression) and high testosterone (associated with PCOS, acne, and cycle irregularities) are clinically significant and measured by this test.
• DHEAS (DS): The primary adrenal androgen precursor in women, declining steadily from the mid-30s and accelerating under chronic stress. Low DHEAS is associated with persistent fatigue, low libido, poor stress resilience, worsening perimenopausal symptoms, and reduced testosterone availability. Elevated DHEAS is associated with adrenal overactivity, PCOS, and androgen-driven acne.
• Cortisol (C) — 4-point: Measured at morning, noon, evening, and night to map the full daily adrenal stress rhythm. In women, cortisol dysregulation suppresses progesterone, impairs T3 conversion, drives oestrogen dominance, and disrupts sleep and blood sugar regulation. The 4-point profile reveals burnout, high reactivity, or dysrhythmic patterns that a single cortisol reading cannot detect.

Blood Spot — Full Thyroid Panel

• TSH (Thyroid Stimulating Hormone): The standard first-line thyroid screen — but in women, TSH alone misses cortisol-driven T3 suppression, oestrogen-related changes in thyroid binding, early thyroid insufficiency, and Hashimoto’s autoimmunity that may be present for years before TSH becomes abnormal.
• Free T3 (FT3): The active thyroid hormone. The most clinically important marker for women experiencing hypothyroid symptoms — fatigue, weight gain, cold intolerance, hair loss, brain fog — with a normal TSH. Low FT3 with normal TSH is the hallmark of cortisol-driven thyroid suppression.
• Free T4 (FT4): The thyroid’s primary output hormone. Low FT4 with normal TSH indicates early thyroid insufficiency or impaired conversion — particularly relevant for women on HRT or the contraceptive pill, which increase thyroid-binding globulin.
• Total T4 (TT4): Provides the full T4 context including bound fraction — important for women whose oestrogen levels alter thyroid hormone binding and affect the ratio of free to total T4.
• TPO Antibodies (Anti-TPO): The primary marker for Hashimoto’s thyroiditis — the most common cause of hypothyroidism in women. Elevated TPO antibodies frequently precede abnormal TSH by years.
• Thyroglobulin Antibodies (Anti-Tg): A second autoimmune marker for complete Hashimoto’s screening. Some women have elevated Tg antibodies with normal TPO — making both essential for accurate autoimmune thyroid assessment.

Who Should Consider This Test?

This test is particularly relevant for women who experience:

• Persistent fatigue or exhaustion that does not improve with sleep or rest
• Unexplained weight gain or difficulty losing weight despite diet and exercise
• PMS, heavy, irregular, or absent periods
• Breast tenderness, bloating, or mood swings in the second half of the cycle
• Perimenopausal or menopausal symptoms: hot flushes, night sweats, vaginal dryness, low mood
• Low libido or reduced sexual interest
• Brain fog, poor concentration, or memory issues
• Anxiety, irritability, or emotional volatility
• Insomnia, night waking, or unrefreshing sleep
• Hair thinning, dry skin, or brittle nails
• Feeling cold all the time, or temperature sensitivity
• Acne, excess facial hair, or scalp hair loss
• Fertility difficulties or recurrent miscarriage
• Diagnosed or suspected PCOS or Hashimoto’s thyroiditis
• Currently on HRT, the contraceptive pill, or thyroid medication and wanting a full hormonal picture
• Chronic stress or burnout

Key Features

• 13-marker combined saliva and blood spot panel — the most comprehensive at-home female hormone and thyroid test available
• All three oestrogens (E1, E2, E3) measured via LC-MS/MS saliva testing — the gold standard for bioavailable hormone measurement
• Full 6-marker thyroid panel including TPO and Tg antibodies
• 4-point cortisol profile revealing the full daily adrenal rhythm
• Results within 3–5 working days after lab receipt
• Expert analysis by a Hormone Specialist PhD Doctor
• Clear graphical and numerical results with personalised commentary
• All-inclusive price — laboratory fees included, no hidden costs
• Valid for 12 months from purchase

How It Works

1. Order the kit online — delivered directly to your door.
2. Collect your saliva samples at four time points (morning, noon, evening, night) for the hormone and cortisol panel, and your blood spot sample via a simple finger-prick for the thyroid panel, following the detailed instructions provided. Guidance on optimal cycle timing is included.
3. Post your samples to the lab using the return instructions included in your kit.
4. Receive your results within 3–5 working days, with specialist commentary and clear next-step guidance.

What Your Report Includes

• All 13 marker results with female-specific reference ranges
• Visual charts for all seven saliva hormones, your full cortisol daily curve, and thyroid panel values
• Clinical interpretation of how your oestrogens, progesterone, testosterone, DHEAS, cortisol, and thyroid markers interact
• Specialist commentary by a Hormone Specialist PhD Doctor
• Personalised next-step recommendations

Frequently Asked Questions

What does this test measure?

Oestradiol (E2), Oestriol (E3), Oestrone (E1), Progesterone, Testosterone, DHEAS, and 4-point Cortisol (saliva) plus TSH, Free T3, Free T4, Total T4, TPO Antibodies, and Thyroglobulin Antibodies (blood spot) — 13 markers in total.

Why measure all three oestrogens?

Measuring only oestradiol (E2) gives an incomplete picture of oestrogen status. Oestrone (E1) is the dominant postmenopausal oestrogen and drives oestrogen-dominant symptoms in older women; oestriol (E3) reflects oestrogen metabolism and tissue activity. Together, the three oestrogen values reveal oestrogen dominance, oestrogen deficiency, and conversion pathway dysfunction that cannot be assessed from E2 alone.

When in my cycle should I collect my samples?

Guidance on optimal cycle timing is included in the kit. For most women, collection in the luteal phase (days 19–21 of a 28-day cycle) provides the most clinically useful progesterone and oestrogen values.

Can I use this test if I am on HRT, the contraceptive pill, or thyroid medication?

Yes. HRT and the pill significantly affect oestrogen, progesterone, and thyroid binding — which is precisely why a comprehensive panel is more informative than standard blood tests for women on hormonal treatment. Follow the timing guidance in your kit.

Why saliva instead of blood for sex hormones?

Saliva measures bioavailable (free, active) hormones — the fraction actually reaching your cells and tissues. Blood tests measure total hormone including the bound, inactive fraction, which can mask the imbalances most relevant to symptoms. Saliva LCMS is the gold standard for assessing bioavailable sex hormones and cortisol.

When will I get my results?

Within 3–5 working days after your samples reach the laboratory.

Are there hidden costs?

No. Laboratory analysis and specialist review are fully included. You are responsible for postage to the lab.

How long is the kit valid?

12 months from purchase.

Why We Partner with ZRT Laboratory

At Hormone Lab UK, every home test kit is analysed by ZRT Laboratory, a globally recognised, CLIA-certified diagnostic and research laboratory specialising in hormone testing, thyroid testing, fertility testing, adrenal function, neurotransmitter analysis, cardiometabolic health, heavy metals, and wellness testing. Founded in 1998 by renowned biochemist and breast cancer researcher Dr. David Zava, PhD, ZRT has become one of the world’s leading laboratories for advanced functional health testing.

With more than 11 million laboratory tests performed and healthcare professionals in over 96 countries relying on its expertise, ZRT is recognised for scientific excellence, analytical accuracy, and continuous innovation. The laboratory pioneered at-home saliva hormone testing, introduced the first commercially available dried blood spot (DBS) hormone tests, and developed Dried Urine Testing (DUTS), helping make advanced laboratory diagnostics more accessible and clinically meaningful.

Every sample is analysed using state-of-the-art LC-MS/MS and ICP-MS technology under rigorous quality control standards. ZRT collaborates with the CDC, NIH, and leading universities, supporting ongoing research and advances in laboratory medicine.