By David Zava, ZRT Laboratory Delivery of the bioidentical hormones estradiol (E2), progesterone (Pg), and testosterone (T) through the skin as a cream or gel (topically) has become a mainstay of bioidentical hormone replacement therapy (BHRT) for women and men. A plethora of FDA-approved pharmaceuticals, compounded, and even over-the-counter topical BHRT products are available. The popularity of these products lies not only in their ease of use but in proven clinical efficacy [1-5] in treating hormonal deficiencies mostly brought on by ageing of the female (menopause) and male (andropause) reproductive systems. Dosing for Optimal Clinical Benefit Over the past 30 or so...
When it comes to topical testosterone therapy, more is not always better. Dr. Allison Smith of ZRT Laboratory explains the U-shaped curve phenomenon — where both too little and too much testosterone produce the same symptoms — and why starting at low doses and titrating carefully is essential. She also outlines the key markers to check when a man’s testosterone numbers look good on paper but his symptoms persist.
Eating well and reducing stress but still can’t shift the weight? You’re not alone — and hormones are very likely involved. In this Q&A, Hormone Health Educator Candace Burch of ZRT Laboratory answers the most common questions from women struggling with hormone-related weight gain: from persistently high cortisol and adrenal fatigue, to BHRT monitoring, how long results take, and why testing is essential for getting the dose just right.
Hot flashes, mood instability, brain fog and memory changes during perimenopause are not “all in your head” — but they are very much in your brain. In this in-depth clinical article, Dr. Kate Placzek of ZRT Laboratory explains how declining estradiol disrupts brain glucose metabolism, neurotransmitter signalling and thermoregulation, why perimenopause represents a window of neurological vulnerability, and why the timing of hormone replacement therapy is critical to protecting long-term brain health.
The Women’s Health Initiative (WHI) trial cast a long shadow over hormone replacement therapy — but it enrolled women well over a decade past menopause. Two newer trials, ELITE and KEEPS, specifically studied HRT started early in the postmenopausal period. Their findings on cardiovascular health, sexual function, sleep, mood and cognition paint a more nuanced and encouraging picture. Here is what the latest research shows.
