Male Hormone & Thyroid Test Kit | Specialist Doctor Report Included

Test ID: SB-647M | Saliva LCMS Hormones 7 + Blood Spot Thyroid Panel

The Male Hormone & Thyroid Test Kit is the most comprehensive at-home hormone and thyroid profile available for men, measuring 13 key hormones and markers — 7 sex and stress hormones via saliva LCMS and a full 6-marker thyroid panel via blood spot. It is designed to identify the hormonal root causes behind the symptoms that affect men most: persistent fatigue, low testosterone, poor recovery, weight gain, low libido, brain fog, and stress-driven hormonal decline.

What makes this test uniquely valuable is the breadth and clinical depth of what it measures together. Testosterone alone does not explain hormonal health in men — its function depends on the balance between oestradiol, progesterone, DHEAS, and cortisol, and its availability is directly constrained by thyroid function. This test measures the entire system: the androgen-oestrogen balance, the adrenal stress load, and the thyroid's capacity to support metabolism, testosterone synthesis, and cognitive performance. No single test provides more actionable hormonal insight for a man seeking to understand and optimise his health.

Test from home with confidence — no clinic visit required. Results within 3–5 working days.

Why This Test Is Uniquely Suited to Men

Male hormonal health is determined by the interaction between testosterone, oestradiol, progesterone, DHEAS, cortisol, and thyroid hormones — not by any single marker in isolation:

• Testosterone is only part of the picture — total testosterone can appear normal while free testosterone is suppressed by high SHBG; oestradiol from aromatase conversion can be elevated, suppressing libido and causing gynaecomastia; progesterone deficiency allows DHT conversion to go unchecked; and cortisol depletion or excess alters testosterone availability at every level; this test assesses the full androgenic context
• Oestradiol in men is essential but often imbalanced — men need oestradiol for bone health, cardiovascular protection, and cognitive function; but excess oestradiol — from visceral fat, alcohol, or ageing — suppresses testosterone, drives fat accumulation, causes water retention, and reduces sexual function; only measuring oestradiol alongside testosterone reveals whether the ratio is clinically appropriate
• Progesterone in men is the overlooked androgen regulator — progesterone inhibits 5-alpha reductase, blocking the conversion of testosterone to DHT; low progesterone in men increases DHT, driving scalp hair loss, prostate enlargement risk, and sebaceous gland activity; it also has direct anti-oestrogenic and anti-inflammatory effects that protect male hormonal balance
• DHEAS is the adrenal androgen reserve in men — declining from the mid-30s, low DHEAS is associated with fatigue, low testosterone precursor availability, poor stress resilience, reduced libido, and accelerated hormonal ageing; elevated DHEAS under chronic stress or overtraining raises androgen load and drives acne and cardiovascular risk
• Cortisol suppresses testosterone at every level — through pregnenolone steal, HPA axis dysregulation, and direct Leydig cell suppression, chronic cortisol elevation depletes testosterone, disrupts sleep, drives visceral fat, and promotes aromatase-driven oestradiol excess; the 4-point cortisol profile identifies the specific pattern and severity of adrenal dysregulation
• Thyroid function directly supports testosterone synthesis and metabolism — hypothyroidism suppresses Leydig cell testosterone production, impairs protein metabolism, slows recovery, and compounds all symptoms of low testosterone; cortisol-driven T3 suppression produces identical symptoms with a normal TSH; TPO and Tg antibodies detect Hashimoto’s autoimmunity years before TSH becomes abnormal

What This Test Measures

Saliva — 7 Sex & Stress Hormones (LCMS)

• Oestradiol (E2): Present in men via aromatase conversion of testosterone. Critical for bone density, cardiovascular health, and cognitive function — but elevated oestradiol suppresses testosterone, causes gynaecomastia, increases water retention, and reduces libido. The oestradiol-to-testosterone ratio is one of the most clinically important values in male hormonal health.
• Oestriol (E3): Measured to assess oestrogen conversion pathways and metabolic activity. In men, elevated E3 can indicate excessive aromatase activity or oestrogen precursor exposure; low E3 relative to E2 can reflect suboptimal oestrogen metabolism.
• Oestrone (E1): Produced by conversion of androgens in adipose tissue. Elevated oestrone in men with visceral fat drives oestrogen dominance, compounds testosterone suppression, and is associated with increased cardiovascular and metabolic risk.
• Progesterone (Pg): Present in men in small but clinically important amounts. Acts as a natural 5-alpha reductase inhibitor, blocking DHT conversion; has direct anti-oestrogenic and neuroprotective effects; and supports thyroid function and sleep quality. Low progesterone in men is associated with elevated DHT, prostate risk, scalp hair loss, anxiety, and poor sleep.
• Testosterone (T): The primary male androgen — responsible for energy, libido, muscle mass, bone density, cognitive performance, and mood. Saliva testing measures the bioavailable (free, active) fraction that actually reaches cells and tissues — providing clinically superior information to total blood testosterone, which includes the bound, inactive fraction.
• DHEAS (DS): The primary adrenal androgen precursor in men, declining steadily from the mid-30s. Low DHEAS is associated with fatigue, low testosterone precursor availability, reduced libido, poor stress resilience, and accelerated hormonal ageing. Elevated DHEAS under chronic stress or overtraining increases the androgenic load and raises cardiovascular and inflammatory risk.
• Cortisol (C) — 4-point: Measured at morning, noon, evening, and night to map the full daily adrenal rhythm. In men, cortisol dysregulation suppresses testosterone, drives visceral fat and aromatase activity, impairs T3 conversion, and disrupts overnight testosterone production during deep sleep. The 4-point profile identifies burnout, high reactivity, and dysrhythmic patterns that a single cortisol measurement cannot reveal.

Blood Spot — Full Thyroid Panel

• TSH (Thyroid Stimulating Hormone): The standard first-line thyroid screen — but in men, TSH alone misses cortisol-driven T3 suppression, early thyroid insufficiency, and Hashimoto’s autoimmunity. A normal TSH does not rule out clinically significant thyroid impairment in symptomatic men.
• Free T3 (FT3): The active thyroid hormone that drives metabolism, energy, testosterone synthesis support, body temperature, and cognitive function. Low FT3 with normal TSH is the most commonly missed thyroid pattern in men under chronic stress — producing hypothyroid symptoms despite “normal” blood results.
• Free T4 (FT4): The thyroid’s primary output hormone, converted to active T3 in peripheral tissues. Low FT4 with normal TSH indicates early thyroid insufficiency or impaired conversion, often preceding symptomatic hypothyroidism by years.
• Total T4 (TT4): Provides the full T4 context including bound fraction — useful for assessing overall thyroid output and interpreting FT4 in the context of TRT or other hormonal therapies that may affect thyroid binding.
• TPO Antibodies (Anti-TPO): The primary marker for Hashimoto’s thyroiditis in men. Elevated TPO antibodies frequently precede abnormal TSH by years and are associated with progressive thyroid decline, fatigue, and metabolic deterioration.
• Thyroglobulin Antibodies (Anti-Tg): A second autoimmune marker essential for complete Hashimoto’s screening — some men have elevated Tg antibodies with normal TPO, making both markers necessary for accurate autoimmune thyroid assessment.

Who Should Consider This Test?

This test is particularly relevant for men who experience:

• Persistent fatigue or exhaustion that does not improve with sleep or rest
• Low libido or reduced sexual interest
• Erectile dysfunction or reduced sexual performance
• Unexplained weight gain or difficulty losing body fat, particularly around the abdomen
• Poor recovery from exercise, overtraining, or sustained high workload
• Brain fog, poor concentration, or reduced cognitive sharpness
• Low mood, reduced motivation, or mild depression
• Feeling cold all the time, or intolerance to cold temperatures
• Dry skin, hair thinning or loss, or slow wound healing
• Acne, oily skin, or scalp hair loss alongside other hormonal symptoms
• Gynaecomastia or breast tissue sensitivity
• Insomnia, night waking, or unrefreshing sleep
• Chronic stress, burnout, or sustained high workload
• Symptoms of low testosterone with inconclusive standard blood results
• Currently on TRT and wanting a comprehensive hormonal and thyroid picture
• Family history of thyroid disease or autoimmune conditions
• Men over 35 wanting a complete hormonal health baseline

Key Features

• 13-marker combined saliva LCMS and blood spot panel — the most comprehensive at-home male hormone and thyroid test available
• All three oestrogens (E1, E2, E3) plus testosterone, progesterone, DHEAS, and 4-point cortisol measured via bioavailable saliva LCMS
• Full 6-marker thyroid panel including TPO and Tg antibodies
• Results within 3–5 working days after lab receipt
• Expert analysis by a Hormone Specialist PhD Doctor
• Clear graphical and numerical results with personalised commentary
• All-inclusive price — laboratory fees included, no hidden costs
• Valid for 12 months from purchase

How It Works

1. Order the kit online — delivered directly to your door.
2. Collect your saliva samples at four time points (morning, noon, evening, night) for the hormone and cortisol panel, and your blood spot sample via a simple finger-prick for the thyroid panel. Morning saliva should be collected before 9am for optimal cortisol accuracy.
3. Post your samples to the lab using the return instructions included in your kit.
4. Receive your results within 3–5 working days, with specialist commentary and clear next-step guidance.

What Your Report Includes

• All 13 marker results with male-specific reference ranges
• Visual charts for all seven saliva hormones, your full cortisol daily curve, and thyroid panel values
• Clinical interpretation of how your testosterone, oestradiol, progesterone, DHEAS, cortisol, and thyroid markers interact
• Specialist commentary by a Hormone Specialist PhD Doctor
• Personalised next-step recommendations

Frequently Asked Questions

What does this test measure?

Oestradiol (E2), Oestriol (E3), Oestrone (E1), Progesterone, Testosterone, DHEAS, and 4-point Cortisol (saliva) plus TSH, Free T3, Free T4, Total T4, TPO Antibodies, and Thyroglobulin Antibodies (blood spot) — 13 markers in total.

Why do men need oestrogen tested?

Men produce oestradiol through aromatase conversion of testosterone — a process that increases with visceral fat, alcohol, and ageing. Oestradiol is essential for bone health and cardiovascular protection in men, but excess oestradiol suppresses testosterone, causes gynaecomastia, and drives fat accumulation. Measuring all three oestrogens alongside testosterone reveals whether the androgen-oestrogen ratio is clinically balanced.

Why saliva instead of blood for sex hormones?

Saliva measures bioavailable (free, active) hormones — the fraction actually reaching your cells and tissues. Blood tests measure total hormone including the bound, inactive fraction, which can mask the imbalances most relevant to symptoms. Saliva LCMS is the gold standard for assessing bioavailable sex hormones and cortisol.

Can I use this test if I am on TRT or levothyroxine?

Yes. This test is particularly valuable for men on TRT who want to understand their oestradiol balance, cortisol pattern, and thyroid function alongside testosterone. TRT can increase aromatisation and affect thyroid binding — making a comprehensive panel essential for monitoring therapy safely.

When will I get my results?

Within 3–5 working days after your samples reach the laboratory.

Are there hidden costs?

No. Laboratory analysis and specialist review are fully included. You are responsible for postage to the lab.

How long is the kit valid?

12 months from purchase.

Why We Partner with ZRT Laboratory

At Hormone Lab UK, every home test kit is analysed by ZRT Laboratory, a globally recognised, CLIA-certified diagnostic and research laboratory specialising in hormone testing, thyroid testing, fertility testing, adrenal function, neurotransmitter analysis, cardiometabolic health, heavy metals, and wellness testing. Founded in 1998 by renowned biochemist and breast cancer researcher Dr. David Zava, PhD, ZRT has become one of the world’s leading laboratories for advanced functional health testing.

With more than 11 million laboratory tests performed and healthcare professionals in over 96 countries relying on its expertise, ZRT is recognised for scientific excellence, analytical accuracy, and continuous innovation. The laboratory pioneered at-home saliva hormone testing, introduced the first commercially available dried blood spot (DBS) hormone tests, and developed Dried Urine Testing (DUTS), helping make advanced laboratory diagnostics more accessible and clinically meaningful.

Every sample is analysed using state-of-the-art LC-MS/MS and ICP-MS technology under rigorous quality control standards. ZRT collaborates with the CDC, NIH, and leading universities, supporting ongoing research and advances in laboratory medicine.