Male Adrenal Function Saliva Test Kit (LCMS) | Specialist Doctor Report Included

Test ID: S-121

The Male Adrenal Function Saliva Test Kit (LCMS) provides a complete at-home assessment of adrenal function and stress hormones specifically designed for men. This test measures five key hormones — DHEAS and Cortisol at four points throughout the day (morning, noon, evening, and night) — to reveal how your adrenal glands are managing stress, energy, and the critical relationship between cortisol and testosterone across the full day.

For men, adrenal function is not simply about stress management — it is a direct determinant of testosterone levels, muscle mass, body composition, sexual health, and cognitive performance. Chronically dysregulated cortisol and depleted DHEAS are among the most common and most underdiagnosed drivers of hormonal decline in men. This test gives you the evidence to understand exactly what is happening and why.

Test from home with confidence — no clinic visit required.

Why Adrenal Function Is a Critical Issue for Men

The adrenal glands produce cortisol and DHEAS — hormones that regulate stress, energy, immunity, and inflammation. In men, these hormones are also in a direct biological relationship with testosterone:

• Cortisol directly suppresses testosterone — both share the same hormonal precursor (pregnenolone); under chronic stress, the body prioritises cortisol at the expense of testosterone through “pregnenolone steal”
• DHEAS is the primary adrenal precursor to testosterone — declining DHEAS (which begins from the late 20s and accelerates under chronic stress) directly reduces testosterone availability, libido, muscle mass, and stress resilience
• High cortisol promotes visceral fat and aromatisation — elevated cortisol drives abdominal fat accumulation, which increases aromatase activity and converts testosterone to oestrogen, compounding hormonal decline
• Cortisol disrupts sleep-based testosterone synthesis — elevated evening and night cortisol suppresses the deep sleep phases during which 70% of daily testosterone is produced
• Adrenal burnout leads to hormonal collapse — when the adrenals are depleted, both cortisol and DHEAS fall, causing total exhaustion, loss of drive, and andropause-like symptoms even in younger men

What This Test Measures

• DHEAS (DS): The primary adrenal precursor to testosterone in men. Low DHEAS is associated with persistent fatigue, low libido, muscle loss, poor stress resilience, reduced testosterone effectiveness, and andropause symptoms. DHEAS declines naturally from the late 20s but can fall dramatically under chronic stress, overtraining, or burnout.
• Morning Cortisol: Evaluates the Cortisol Awakening Response — the critical morning surge that sets testosterone balance, energy, and drive for the day. In men, too high suppresses morning testosterone; too low signals adrenal burnout and impaired recovery.
• Noon Cortisol: Measures mid-day stress response. Chronically elevated noon cortisol in men promotes insulin resistance, visceral fat, and oestrogen conversion — compounding testosterone decline across the afternoon.
• Evening Cortisol: Assesses the wind-down phase. Cortisol should be declining significantly by early evening to allow testosterone and growth hormone to rise during the first sleep cycles.
• Night Cortisol: Monitors cortisol before sleep. Elevated night cortisol directly suppresses the deep sleep testosterone synthesis that accounts for the majority of daily testosterone production in men.

• How and When to Collect Your Saliva Samples: Saliva Testing Instructions
• Click to see the sample >> Adrenal Stress Test Result Report

Who Should Consider This Test?

This test is particularly relevant for men who experience:

• Persistent fatigue or exhaustion that sleep does not resolve
• Difficulty waking in the morning or feeling unrefreshed
• Insomnia, night waking, or inability to switch off at bedtime
• Low libido or reduced sexual interest
• Erectile dysfunction or reduced sexual performance
• Loss of muscle mass or poor recovery after training
• Unexplained abdominal fat gain despite exercise
• Anxiety, irritability, or low mood
• Brain fog, poor focus, or reduced motivation
• Symptoms of low testosterone with inconclusive blood results
• Chronic stress, overtraining, or burnout
• Currently on TRT and wanting a full hormonal picture
• Sugar or salt cravings, especially in the afternoon
• Low blood pressure or dizziness on standing
• Frequent illness or slow recovery

Key Features

• At-home saliva collection — no needles, no clinic visits
• Full-day cortisol profile plus DHEAS — five hormones in a single test
• Fast results within 3–5 working days after lab receipt
• Expert analysis and guidance by a Hormone Specialist PhD Doctor
• Visual charts, hormone levels, and personalised insights in your report
• All-inclusive price — laboratory fees included, no hidden costs
• Valid for 12 months from purchase

How It Works

1. Order the kit online — delivered directly to your door.
2. Collect saliva samples at four times — morning (within 30 minutes of waking, ideally 6–8am), noon, evening, and night — following the detailed instructions provided.
3. Post your samples to the lab using the return instructions included in your kit.
4. Receive your results within 3–5 working days with specialist commentary and clear next-step guidance.

What Your Report Includes

• DHEAS level and all four cortisol readings with reference ranges
• Visual charts showing your full daily cortisol curve and DHEAS status
• Explanation of what your results mean for testosterone, adrenal health, and physical performance
• Specialist commentary by a Hormone Specialist PhD Doctor
• Personalised next-step recommendations

Frequently Asked Questions

What does this test measure?

DHEAS and Cortisol at four points throughout the day (morning, noon, evening, night) — providing a complete picture of your adrenal stress response, DHEAS status, and their impact on testosterone.

Why is this test particularly important for men?

Cortisol and DHEAS are direct regulators of testosterone. Chronic cortisol elevation suppresses testosterone through pregnenolone steal, promotes oestrogen conversion via visceral fat, and blocks sleep-based testosterone synthesis. DHEAS is the adrenal testosterone precursor — its decline is one of the most underrecognised causes of andropause symptoms in men.

Can I use this test if I am on TRT?

Yes. This test is suitable for men on testosterone replacement therapy and provides valuable insight into whether cortisol dysregulation is undermining the effectiveness of TRT.

Why use saliva instead of blood?

Saliva testing measures bioavailable (active) hormones — the fraction actually affecting your cells — and avoids the cortisol spike triggered by a blood draw, which can distort results.

How accurate is the test?

Samples are analysed using advanced LC-MS/MS technology for precise hormone measurement.

When will I get my results?

Within 3–5 working days after your sample reaches the laboratory.

How long is the kit valid?

12 months from purchase.

Who pays for shipping to the lab?

You are responsible for posting your samples to the laboratory. Clear instructions are included in your kit.

Why We Partner with ZRT Laboratory

At Hormone Lab UK, every home test kit is analysed by ZRT Laboratory, a globally recognised, CLIA-certified diagnostic and research laboratory specialising in hormone testing, thyroid testing, fertility testing, adrenal function, neurotransmitter analysis, cardiometabolic health, heavy metals, and wellness testing. Founded in 1998 by renowned biochemist and breast cancer researcher Dr. David Zava, PhD, ZRT has become one of the world’s leading laboratories for advanced functional health testing.

With more than 11 million laboratory tests performed and healthcare professionals in over 96 countries relying on its expertise, ZRT is recognised for scientific excellence, analytical accuracy, and continuous innovation. The laboratory pioneered at-home saliva hormone testing, introduced the first commercially available dried blood spot (DBS) hormone tests, and developed Dried Urine Testing (DUTS), helping make advanced laboratory diagnostics more accessible and clinically meaningful.

Every sample is analysed using state-of-the-art LC-MS/MS and ICP-MS technology under rigorous quality control standards. ZRT collaborates with the CDC, NIH, and leading universities, supporting ongoing research and advances in laboratory medicine.

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