Male Comprehensive Hormone, Thyroid & CardioMetabolic Test | Specialist Doctor Report Included

Test ID: SB-652 | Saliva LCMS Hormones 7 with 4-Point Cortisol + Blood Spot Full Thyroid & CardioMetabolic Panel

The Male Comprehensive Hormone, Thyroid & CardioMetabolic Test is the most complete at-home health profile available for men anywhere in the UK, measuring 22 key hormones and markers across four interconnected systems in a single kit: androgenic and sex hormone balance, the full daily cortisol stress rhythm, complete thyroid function including autoimmune antibodies, and a comprehensive cardiometabolic panel. It uses saliva LCMS (Liquid Chromatography–Mass Spectrometry) for sex hormones and cortisol — the gold standard for bioavailable hormone measurement — combined with a full blood spot thyroid and cardiometabolic panel.

This test exists because male health does not divide neatly into separate systems. In men, testosterone, cortisol, thyroid hormones, and insulin form a single integrated regulatory network — one in which disruption to any system cascades through all the others. Cortisol depletes testosterone through pregnenolone steal and Leydig cell suppression, drives visceral fat and aromatase-driven oestradiol conversion, impairs thyroid T3 conversion, and causes insulin resistance — all simultaneously. Hypothyroidism directly suppresses testosterone synthesis, compounds every symptom of androgen decline, and is missed by TSH alone in the presence of cortisol-driven T3 suppression. Insulin resistance promotes aromatase activity and further testosterone decline. And elevated oestradiol feeds back to suppress the hypothalamic-pituitary-gonadal axis, completing the cycle. No standard blood panel tests all four systems together. This one does.

Test from home with confidence — no clinic visit required. Results within 3–5 working days.

The Male Hormonal-Metabolic System: Why All Four Must Be Tested Together

• Testosterone is the central coordinator of male metabolic and cardiovascular health — testosterone maintains insulin sensitivity, HDL cholesterol, lean muscle mass, bone density, and vascular health; low testosterone independently raises triglycerides, suppresses HDL, promotes visceral fat, elevates hsCRP, and increases the risk of metabolic syndrome, type 2 diabetes, and cardiovascular disease; at the same time, metabolic dysfunction further suppresses testosterone through aromatase and HPA axis dysregulation — a compounding cycle that single-system tests cannot interrupt
• Cortisol is the primary suppressor of testosterone and the primary driver of male cardiometabolic deterioration — through pregnenolone steal, direct Leydig cell suppression, and HPA axis dysregulation, chronic cortisol depletes testosterone while simultaneously driving visceral fat, aromatase-driven oestradiol excess, insulin resistance, triglyceride elevation, and hsCRP — a five-way attack that only the combined 4-panel test can fully characterise and explain
• Thyroid dysfunction is a major and systematically missed cause of low testosterone in men — hypothyroidism directly suppresses Leydig cell testosterone production and impairs the protein metabolism, recovery, and energy generation that testosterone depends on; cortisol-driven T3 suppression produces the same hypothyroid symptom picture with a normal TSH; Hashimoto’s thyroiditis is present in men for years before TSH becomes abnormal; and TSH alone misses all three of these patterns — making the full thyroid panel including FT3, FT4, TT4, TPO, and Tg antibodies essential for any man with unresolved fatigue, weight gain, or low testosterone symptoms
• Insulin resistance and testosterone decline are mutually reinforcing in men — elevated insulin promotes visceral fat and aromatase-driven oestrogen conversion; low testosterone worsens insulin sensitivity; together they drive metabolic syndrome, type 2 diabetes, and erectile dysfunction simultaneously; fasting insulin is the earliest detectable marker of this process — elevated years before HbA1c or fasting glucose becomes abnormal — and cannot be assessed by any standard NHS hormone panel
• hsCRP is the convergence marker of the entire male hormonal-metabolic axis — elevated by low testosterone, cortisol dysregulation, insulin resistance, visceral fat, oestradiol excess, and Hashimoto’s autoimmunity simultaneously; it is a stronger independent predictor of cardiovascular events and all-cause mortality in men than LDL cholesterol, and is directly modifiable through integrated hormonal, thyroid, and metabolic intervention

What This Test Measures — 22 Markers Across Four Systems

Saliva LCMS — Sex Hormones (6 markers)

• Oestradiol (E2): Present in men via aromatase conversion of testosterone. Essential for bone density, cardiovascular protection, and cognitive function — but excess oestradiol from visceral fat, cortisol, or alcohol suppresses testosterone via the HPG axis, causes gynaecomastia, raises triglycerides, and elevates cardiovascular risk. The oestradiol-to-testosterone ratio is a primary androgenic and cardiometabolic health indicator in men. Measured by LCMS for the free, bioavailable fraction.
• Oestriol (E3): Reflects oestrogen conversion pathways and aromatase activity in men. Elevated E3 indicates increased oestrogen precursor load or conversion; the E3-to-E2 ratio provides metabolic oestrogen context beyond what E2 alone reveals.
• Oestrone (E1): Produced by androgen conversion in adipose tissue. Elevated oestrone in men with visceral fat or metabolic dysfunction drives systemic oestrogenic load, compounds testosterone suppression, and is associated with increased cardiometabolic and inflammatory risk. A key indicator of adipose-driven hormonal disruption in men.
• Progesterone (Pg): Present in men in small but clinically important amounts. Acts as a natural 5-alpha reductase inhibitor, blocking DHT conversion; has direct anti-oestrogenic, anti-inflammatory, neuroprotective, and cardioprotective effects; supports insulin sensitivity, sleep quality, and thyroid function. Low progesterone in men is associated with elevated DHT, prostate risk, anxiety, cardiometabolic inflammation, and poor sleep architecture.
• Testosterone (T): The primary male androgen — responsible for energy, libido, muscle mass, bone density, insulin sensitivity, HDL maintenance, and cardiovascular health. Saliva LCMS measures the free, bioavailable fraction — the clinically relevant value that drives androgenic function and correlates with symptoms, as opposed to total blood testosterone which includes the SHBG-bound, inactive fraction that can mask significant free testosterone deficiency.
• DHEAS (DS): The primary adrenal androgen precursor in men, declining from the mid-30s and depleted under chronic stress or overtraining. Low DHEAS reduces testosterone precursor availability, impairs stress resilience, and has direct anti-inflammatory and insulin-sensitising effects that protect against cardiometabolic deterioration. Elevated DHEAS under adrenal overactivation drives androgen excess and inflammatory cardiovascular risk.

Saliva — 4-Point Cortisol Profile (4 markers)

• Morning Cortisol: The Cortisol Awakening Response — sets testosterone availability, LH pulsatility, insulin sensitivity, and thyroid activation for the day. An exaggerated response drives morning testosterone suppression and insulin resistance; a blunted response signals HPA burnout, impaired thyroid activation, and metabolic underperformance from the first hours.
• Noon Cortisol: Elevated noon cortisol promotes visceral fat, insulin resistance, and aromatase-driven testosterone-to-oestradiol conversion. Simultaneously impairs thyroid T4-to-T3 conversion, raises triglycerides via hepatic lipid dysregulation, and suppresses HDL — the direct mechanism by which chronic midday stress drives cardiometabolic and androgenic deterioration in men.
• Evening Cortisol: Should decline significantly to allow testosterone and growth hormone to rise during early sleep cycles. Elevated evening cortisol suppresses overnight testosterone production, elevates SHBG through hepatic cortisol-SHBG coupling, impairs thyroid cellular uptake, and maintains the insulin-resistant, pro-inflammatory state into the night.
• Night Cortisol: Suppresses the deep sleep phases during which the majority of daily testosterone is produced and growth hormone mediates fat metabolism. Drives overnight visceral fat accumulation, fasting insulin elevation, hsCRP rise, and aromatase excess — and worsens Hashimoto’s autoimmune activity through sleep-deprivation-mediated immune dysregulation.

Blood Spot — Full Thyroid Panel (6 markers)

• TSH: Essential first-line thyroid marker — but in men, TSH alone misses cortisol-driven T3 suppression, early thyroid insufficiency, and Hashimoto’s autoimmunity present years before TSH becomes abnormal. Necessary but not sufficient.
• Free T3 (FT3): The active thyroid hormone that drives metabolism, energy, testosterone synthesis support, recovery, and cognitive function in men. Low FT3 with normal TSH is the hallmark of cortisol-driven thyroid suppression — the most commonly missed hormonal pattern in men under chronic occupational or psychological stress.
• Free T4 (FT4): The thyroid’s primary output hormone. Low FT4 with normal TSH indicates early thyroid insufficiency or impaired peripheral conversion — often preceding symptomatic hypothyroidism and testosterone suppression by years.
• Total T4 (TT4): Provides full T4 context including the bound fraction — important interpretive context for men on TRT where thyroid-binding proteins may be affected.
• TPO Antibodies (Anti-TPO): The primary diagnostic marker for Hashimoto’s thyroiditis in men. Frequently elevated years before TSH becomes abnormal; associated with progressive thyroid decline, Leydig cell testosterone suppression, fatigue, and metabolic deterioration. Directly worsened by insulin resistance and cortisol dysregulation — both assessed by this test.
• Thyroglobulin Antibodies (Anti-Tg): Essential second Hashimoto’s marker. Some men have elevated Tg antibodies with normal TPO — making both necessary for complete autoimmune thyroid assessment and early detection of progressive thyroid-driven testosterone suppression.

Blood Spot — CardioMetabolic Panel (6 markers)

• Fasting Insulin: The earliest detectable marker of insulin resistance in men — elevated years before HbA1c becomes abnormal. Directly promoted by cortisol excess, low testosterone, and visceral fat. Elevated fasting insulin drives aromatase activity, increases oestrogen conversion, independently raises cardiovascular risk, and is closely linked to erectile dysfunction and testosterone decline. The most actionable early metabolic marker for men with androgenic symptoms.
• HbA1c: Reflects average blood sugar over 8–12 weeks. Men with chronically elevated cortisol, low testosterone, and hypothyroidism have markedly elevated risk of pre-diabetes and type 2 diabetes; HbA1c provides the medium-term blood sugar context that anchors the fasting insulin result.
• HDL Cholesterol: The protective cardiovascular fraction directly maintained by testosterone. HDL falls with low testosterone, insulin resistance, cortisol elevation, and hypothyroidism — four pathways all assessed by this test. A primary cardiometabolic marker of androgenic decline in men.
• Triglycerides: Elevated by cortisol, insulin resistance, oestradiol excess, and hypothyroidism simultaneously — all four assessed here. Rise before LDL changes and are a primary cardiometabolic risk marker for men with visceral fat, hormonal decline, and thyroid dysfunction.
• Total Cholesterol: Directly elevated by hypothyroidism and low testosterone. Rising cholesterol in men with fatigue and low libido is frequently a hormonal and thyroid event rather than a purely dietary one — requiring the integrated assessment this panel provides.
• hsCRP (High-Sensitivity C-Reactive Protein): One of the strongest independent predictors of cardiovascular events and all-cause mortality in men. Elevated simultaneously by low testosterone, cortisol dysregulation, insulin resistance, visceral fat, oestradiol excess, and Hashimoto’s autoimmunity — all six pathways directly assessed by this panel. The convergence biomarker of the male hormonal-metabolic system.

Who Should Consider This Test?

This test is the ideal choice for men who experience any combination of:

• Persistent fatigue or exhaustion that does not improve with sleep or rest
• Unexplained weight gain or difficulty losing body fat, particularly around the abdomen
• Low libido or reduced sexual interest
• Erectile dysfunction or reduced sexual performance
• Poor recovery from exercise, training, or sustained high workload
• Brain fog, poor concentration, or reduced cognitive sharpness
• Low mood, reduced motivation, or mild depression
• Feeling cold, temperature sensitivity, or slow metabolism
• Dry skin, hair thinning, or slow wound healing
• Acne, scalp hair loss, or gynaecomastia
• Sugar cravings, energy crashes, or afternoon slumps
• Elevated cholesterol, triglycerides, or blood sugar on previous testing
• Insomnia, night waking, or unrefreshing sleep
• Chronic stress, burnout, or sustained high-pressure workload
• Symptoms of low testosterone with normal or inconclusive standard blood results
• Currently on TRT and wanting a comprehensive hormonal, thyroid, and metabolic picture
• Diagnosed or suspected Hashimoto’s thyroiditis or autoimmune thyroid disease
• Family history of thyroid disease, heart disease, diabetes, or metabolic syndrome
• Men over 35 seeking the single most comprehensive at-home androgenic and metabolic health assessment available

Key Features

• 22-marker quad-system panel: saliva LCMS sex hormones, 4-point cortisol, full blood spot thyroid panel, and full cardiometabolic panel — the most comprehensive at-home male health test available in the UK
• Saliva LCMS — gold standard for free, bioavailable testosterone and sex hormone measurement in men
• All three oestrogens (E1, E2, E3) for complete oestrogenic load and aromatase activity assessment
• Full 6-marker thyroid panel including TPO and Tg autoimmune antibodies
• 4-point cortisol profile — the essential lens for interpreting all other results
• Full 6-marker cardiometabolic panel including fasting insulin and hsCRP
• Results within 3–5 working days after lab receipt
• Expert analysis by a Hormone Specialist PhD Doctor
• Clear graphical and numerical results with personalised commentary
• All-inclusive price — laboratory fees included, no hidden costs
• Valid for 12 months from purchase

How It Works

1. Order the kit online — delivered directly to your door.
2. Collect your saliva samples at four time points (morning, noon, evening, night) for the sex hormone and cortisol panel, and your blood spot sample via a simple finger-prick for the thyroid and cardiometabolic panels, following the detailed instructions. Morning saliva should be collected before 9am for optimal cortisol accuracy.
3. Post your samples to the lab using the return instructions in your kit.
4. Receive your results within 3–5 working days with specialist commentary and clear next-step guidance.

What Your Report Includes

• All 22 marker results with male-specific reference ranges
• Visual charts for all six sex hormones, your full 4-point cortisol daily curve, thyroid panel, and all six cardiometabolic markers
• Integrated clinical interpretation of how your testosterone, oestradiol, progesterone, DHEAS, cortisol, thyroid markers, and cardiometabolic results interact as a single male hormonal-metabolic system
• Free testosterone assessment based on bioavailable LCMS measurement
• Oestradiol-to-testosterone ratio and total oestrogenic load analysis
• Cortisol-thyroid T3 conversion and Leydig cell interaction assessment
• Insulin resistance pattern assessment (fasting insulin + HbA1c)
• Cardiovascular risk profile in full androgenic and thyroid hormonal context (HDL, triglycerides, cholesterol, hsCRP)
• Hashimoto’s autoimmunity assessment (TPO + Tg antibodies)
• Specialist commentary by a Hormone Specialist PhD Doctor
• Personalised next-step recommendations

Frequently Asked Questions

What does this test measure?

Oestradiol (E2), Oestriol (E3), Oestrone (E1), Progesterone, Testosterone, DHEAS (saliva LCMS) + 4-point Cortisol (saliva: morning, noon, evening, night) + TSH, Free T3, Free T4, Total T4, TPO Antibodies, Thyroglobulin Antibodies (blood spot) + Fasting Insulin, HbA1c, HDL Cholesterol, Triglycerides, Total Cholesterol, hsCRP (blood spot) — 22 markers in total.

Why is this test better than standard NHS blood tests for men?

Standard NHS testing typically measures total testosterone by immunoassay, uses TSH as the sole thyroid marker, and does not assess cortisol rhythm, thyroid antibodies, fasting insulin, or hsCRP in combination. This test measures free, bioavailable testosterone by LCMS, provides the full 4-point cortisol stress rhythm, screens for Hashimoto’s autoimmunity, and assesses insulin resistance and cardiovascular inflammation — revealing the hormonal, thyroid, and metabolic root causes of symptoms that standard NHS blood panels systematically miss in men.

Why is LCMS used for sex hormones in this test?

LCMS (Liquid Chromatography–Mass Spectrometry) measures the free, bioavailable fraction of hormones — the portion actually reaching cells and driving androgenic function. In men, this distinction is critical: total testosterone measured by immunoassay includes SHBG-bound hormone that is biologically inactive; a man with high SHBG can have normal total testosterone but critically low free testosterone, producing full symptoms of androgen deficiency. LCMS reveals the true androgenic picture that standard blood tests miss.

Can I use this test if I am on TRT or levothyroxine?

Yes. This test is particularly valuable for men on TRT or thyroid medication who want a complete picture of how their treatment is affecting their entire androgenic, thyroid, and cardiometabolic system. TRT increases aromatisation, can alter SHBG, thyroid binding, HDL, and triglycerides — all directly assessed here. Follow the instructions provided in your kit.

Is this test suitable for men with Hashimoto’s or suspected thyroid disease?

Yes — this is the most comprehensive thyroid assessment available in an at-home test for men, including both TPO and Tg antibodies for complete Hashimoto’s screening alongside the full thyroid panel, 4-point cortisol (which drives Hashimoto’s activity), and insulin markers (which worsen thyroid autoimmunity) — providing the full context that standard thyroid blood tests cannot.

When will I get my results?

Within 3–5 working days after your samples reach the laboratory.

Are there hidden costs?

No. Laboratory analysis and specialist review are fully included. You are responsible for postage to the lab.

How long is the kit valid?

12 months from purchase.

Why We Partner with ZRT Laboratory

At Hormone Lab UK, every home test kit is analysed by ZRT Laboratory, a globally recognised, CLIA-certified diagnostic and research laboratory specialising in hormone testing, thyroid testing, fertility testing, adrenal function, neurotransmitter analysis, cardiometabolic health, heavy metals, and wellness testing. Founded in 1998 by renowned biochemist and breast cancer researcher Dr. David Zava, PhD, ZRT has become one of the world’s leading laboratories for advanced functional health testing.

With more than 11 million laboratory tests performed and healthcare professionals in over 96 countries relying on its expertise, ZRT is recognised for scientific excellence, analytical accuracy, and continuous innovation. The laboratory pioneered at-home saliva hormone testing, introduced the first commercially available dried blood spot (DBS) hormone tests, and developed Dried Urine Testing (DUTS), helping make advanced laboratory diagnostics more accessible and clinically meaningful.

Every sample is analysed using state-of-the-art LC-MS/MS and ICP-MS technology under rigorous quality control standards. ZRT collaborates with the CDC, NIH, and leading universities, supporting ongoing research and advances in laboratory medicine.