Male CardioMetabolic & Thyroid Test Kit | Specialist Doctor Report Included

Test ID: SB-642 | Saliva 4-Point Cortisol + Blood Spot Thyroid & CardioMetabolic Panel

The Male CardioMetabolic & Thyroid Test Kit is the most comprehensive at-home multi-system hormone test available for men, measuring 13 key markers across thyroid function, stress hormone rhythm, blood sugar regulation, inflammation, and cardiovascular health. It combines a 4-point saliva cortisol profile with a full blood spot thyroid and cardiometabolic panel — delivering a clinically complete picture of the interconnected systems most responsible for energy, body composition, cardiovascular risk, and hormonal health in men.

In men, thyroid function, cortisol, blood sugar, and cardiovascular risk are not separate concerns — they are components of a single integrated metabolic system that also determines testosterone availability and long-term vitality. Chronic dysregulation across these systems is among the most common and most underdiagnosed drivers of premature hormonal decline, metabolic disease, and cardiovascular risk in men. This test is designed to assess all of them together, providing the complete picture that standard GP blood panels fail to deliver.

Test from home with confidence — no clinic visit required. Results within 3–5 working days.

Why This Test Is Particularly Important for Men

Men face a distinct and frequently underrecognised pattern of metabolic and thyroid risk that is directly compounded by the cortisol–testosterone relationship: 

• Thyroid dysfunction in men is systematically underdiagnosed — men are less likely to be tested for thyroid disease despite carrying significant burden; hypothyroidism in men directly suppresses testosterone production, impairs Leydig cell function, and is a major overlooked cause of low libido, erectile dysfunction, and andropause symptoms
• Cortisol suppresses T3 conversion and testosterone simultaneously — through shared precursor competition (pregnenolone steal) and HPA axis dysregulation, chronic stress depletes both active thyroid hormone and testosterone, while TSH and total testosterone can remain within normal ranges
• Insulin resistance is the metabolic hub in men — elevated insulin drives visceral fat accumulation, which increases aromatase activity, converting testosterone to oestrogen; this simultaneously raises cardiovascular risk, worsens insulin resistance, and reduces the testosterone available for energy, performance, and sexual health
• Men’s cardiovascular risk is driven by hormone-metabolic interactions — low testosterone, high cortisol, insulin resistance, and hypothyroidism each independently raise LDL, triglycerides, and hsCRP; their combination in chronically stressed or hormonally declining men creates a compounding cardiovascular risk profile that is rarely assessed in its entirety
• hsCRP reveals the inflammatory root — elevated C-reactive protein connects thyroid autoimmunity, insulin resistance, visceral fat, and cortisol dysregulation in a single underlying inflammatory process; in men, elevated hsCRP is one of the strongest independent predictors of cardiovascular events and metabolic disease progression

What This Test Measures

Blood Spot — Full Thyroid Panel

• TSH (Thyroid Stimulating Hormone): The standard thyroid screen — but in men, TSH alone misses early thyroid dysfunction, cortisol-driven T3 suppression, and autoimmune thyroid disease. A normal TSH does not rule out clinically significant thyroid impairment in men with symptoms.
• Free T3 (FT3): The active thyroid hormone that drives metabolism, energy production, body temperature, testosterone synthesis support, and cognitive function in men. Low FT3 with normal TSH is the hallmark of cortisol-driven thyroid suppression — the most commonly missed pattern in men under chronic stress or sustained high workload.
• Free T4 (FT4): The thyroid’s primary output hormone, converted to active T3 in peripheral tissues. Low FT4 with normal TSH indicates early thyroid insufficiency or impaired conversion, often preceding symptomatic hypothyroidism by years.
• Total T4 (TT4): Measures total circulating T4 including the bound fraction. Provides important context for interpreting FT4 and assessing overall thyroid output in men on testosterone therapy, which can affect thyroid hormone binding.
• TPO Antibodies (Anti-TPO): The primary diagnostic marker for Hashimoto’s thyroiditis. In men, elevated TPO antibodies are frequently present for years before TSH becomes abnormal, and are associated with progressive thyroid decline, fatigue, and metabolic deterioration.
• Thyroglobulin Antibodies (Anti-Tg): A second autoimmune marker essential for complete Hashimoto’s screening. Some men have elevated Tg antibodies with normal TPO — making both markers necessary for accurate autoimmune thyroid assessment.

Blood Spot — CardioMetabolic Panel

• Fasting Insulin: The earliest detectable marker of insulin resistance in men — elevated years before HbA1c or fasting glucose becomes abnormal. Elevated insulin drives visceral fat, increases aromatase activity (converting testosterone to oestrogen), and independently raises cardiovascular risk.
• HbA1c (Glycated Haemoglobin): Reflects average blood sugar regulation over the preceding 8–12 weeks. Men with low testosterone and high cortisol have significantly elevated risk of pre-diabetes and type 2 diabetes; HbA1c provides the medium-term blood sugar picture that a single fasting glucose cannot.
• HDL Cholesterol: The protective cholesterol fraction. Low HDL in men is strongly associated with insulin resistance, visceral fat, and low testosterone; it is one of the most reliable markers of metabolic syndrome in men.
• Triglycerides: Elevated triglycerides are a hallmark of insulin resistance and cortisol-driven metabolic dysfunction in men; a primary cardiovascular risk marker that often rises before LDL changes and is directly worsened by high cortisol and low testosterone.
• Total Cholesterol: Provides the overall lipid context; rising total cholesterol in men with hypothyroidism and low testosterone is a well-established pattern requiring integrated assessment.
• hsCRP (High-Sensitivity C-Reactive Protein): The gold standard systemic inflammation marker. Elevated hsCRP in men is associated with thyroid autoimmunity, insulin resistance, visceral fat, and testosterone decline — and is one of the strongest independent predictors of cardiovascular events and metabolic disease in men.

Saliva — 4-Point Cortisol Profile

• Morning Cortisol: The Cortisol Awakening Response — critical for activating metabolism, setting testosterone availability, and establishing cognitive performance for the day. A blunted response signals adrenal burnout and impaired recovery; an exaggerated response indicates high stress reactivity and morning testosterone suppression.
• Noon Cortisol: Elevated noon cortisol in men promotes insulin resistance, visceral fat accumulation, and aromatase-driven testosterone-to-oestrogen conversion — a compounding driver of both metabolic and hormonal decline.
• Evening Cortisol: Should be declining significantly to allow testosterone and growth hormone to begin rising during early sleep cycles. Elevated evening cortisol directly suppresses overnight hormonal recovery in men.
• Night Cortisol: Elevated night cortisol suppresses the deep sleep phases during which the majority of daily testosterone is produced and thyroid hormone cellular uptake occurs — a primary driver of low morning testosterone, poor recovery, and persistent fatigue in men.

Who Should Consider This Test?

This test is particularly relevant for men who experience:

• Persistent fatigue or exhaustion that does not improve with rest or sleep
• Unexplained weight gain or difficulty losing body fat despite training and diet
• Brain fog, poor concentration, or reduced cognitive sharpness
• Low mood, reduced motivation, or mild depression
• Feeling cold all the time, or intolerance to cold temperatures
• Dry skin, hair thinning or loss, or slow wound healing
• Low libido or reduced sexual interest
• Erectile dysfunction or reduced performance
• Poor recovery from exercise or overtraining
• Elevated cholesterol or triglycerides on previous testing
• Blood sugar irregularities, sugar cravings, or energy crashes
• Chronic stress, burnout, or sustained high workload
• Insomnia, night waking, or unrefreshing sleep
• Symptoms of low testosterone with inconclusive blood results
• Currently on TRT and wanting a complete metabolic and thyroid picture
• Family history of thyroid disease, diabetes, or heart disease
• Men over 40 wanting a comprehensive metabolic and hormonal health baseline

Key Features

• 13-marker thyroid, cortisol, and cardiometabolic panel in a single at-home kit
• Blood spot collection — simple finger-prick, no clinic visit or venepuncture
• Saliva collection for cortisol — non-invasive, captures bioavailable (active) cortisol at four time points
• Results within 3–5 working days after lab receipt
• Expert analysis by a Hormone Specialist PhD Doctor
• Clear graphical and numerical results with personalised commentary
• All-inclusive price — laboratory fees included, no hidden costs
• Valid for 12 months from purchase

How It Works

1. Order the kit online — delivered directly to your door.
2. Collect your blood spot sample via a simple finger-prick onto the collection card, and your saliva samples at four time points across the day. Morning saliva collection should be completed before 9am for optimal cortisol accuracy.
3. Post your samples to the lab using the return instructions included in your kit.
4. Receive your results within 3–5 working days, with specialist commentary and clear next-step guidance.

What Your Report Includes

• All 13 marker results with male-specific reference ranges
• Visual charts for your cortisol daily curve, thyroid panel, and cardiometabolic markers
• Clinical interpretation of how your thyroid, cortisol, testosterone, and metabolic results interact
• Specialist commentary by a Hormone Specialist PhD Doctor
• Personalised next-step recommendations

Frequently Asked Questions

What does this test measure?

TSH, Free T3, Free T4, Total T4, TPO Antibodies, Thyroglobulin Antibodies, Fasting Insulin, HbA1c, HDL Cholesterol, Triglycerides, Total Cholesterol, hsCRP (blood spot) plus 4-point Cortisol (saliva) — 13 markers in total.

Why test thyroid, cortisol, and cardiometabolic markers together?

In men, these systems converge on testosterone and metabolic health. Cortisol suppresses T3 conversion and testosterone simultaneously; insulin resistance drives visceral fat and oestrogen conversion; thyroid insufficiency raises cardiovascular risk and impairs testosterone synthesis. Testing all together identifies the root cause and the full extent of metabolic and hormonal dysfunction in a single kit.

Can I use this test if I am on TRT or levothyroxine?

Yes. This test is particularly valuable for men on TRT who want to understand whether cortisol dysregulation, thyroid suppression, or metabolic dysfunction is limiting the effectiveness of testosterone therapy. TRT can affect thyroid hormone binding, making FT3 and FT4 measurements especially important alongside TSH.

How accurate is the test?

Blood spot samples are analysed using advanced immunoassay technology; saliva cortisol is measured using LC-MS/MS — the gold standard for bioavailable hormone measurement.

When will I get my results?

Within 3–5 working days after your samples reach the laboratory.

Are there hidden costs?

No. Laboratory analysis and specialist review are fully included. You are responsible for postage to the lab.

How long is the kit valid?

12 months from purchase.

Why We Partner with ZRT Laboratory

At Hormone Lab UK, every home test kit is analysed by ZRT Laboratory, a globally recognised, CLIA-certified diagnostic and research laboratory specialising in hormone testing, thyroid testing, fertility testing, adrenal function, neurotransmitter analysis, cardiometabolic health, heavy metals, and wellness testing. Founded in 1998 by renowned biochemist and breast cancer researcher Dr. David Zava, PhD, ZRT has become one of the world’s leading laboratories for advanced functional health testing.

With more than 11 million laboratory tests performed and healthcare professionals in over 96 countries relying on its expertise, ZRT is recognised for scientific excellence, analytical accuracy, and continuous innovation. The laboratory pioneered at-home saliva hormone testing, introduced the first commercially available dried blood spot (DBS) hormone tests, and developed Dried Urine Testing (DUTS), helping make advanced laboratory diagnostics more accessible and clinically meaningful.

Every sample is analysed using state-of-the-art LC-MS/MS and ICP-MS technology under rigorous quality control standards. ZRT collaborates with the CDC, NIH, and leading universities, supporting ongoing research and advances in laboratory medicine.