Test ID: SB-650 | Sample Type: Saliva + Blood Spot | Technology: LC-MS/MS | Results Time: 3-5 Working Days After Laboratory Receives Sample | Laboratory: ZRT Laboratory - CLIA Certified | Hormone Specialist Doctor Interpretation: Included | Suitable For: Adults and Children | Collect Sample At Home: No Clinic Visit Required
What Does This Test Measure?
Saliva LCMS - Sex Hormones: Estradiol (E2), Estriol (E3), Estrone (E1), Progesterone, Testosterone, DHEAS.
Saliva - 4-Point Cortisol Profile: Morning, Noon, Evening, and Night Cortisol.
Blood Spot - Full Thyroid Panel: TSH, Free T3, Free T4, Total T4, TPO Antibodies, Thyroglobulin Antibodies.
16 markers total - the most clinically comprehensive at-home hormone profile available for women, combining saliva LCMS sex hormones, 4-point cortisol, and a full autoimmune thyroid panel in a single kit.
Related Symptoms
Persistent fatigue, unexplained weight gain, PMS, heavy or irregular periods, breast tenderness, perimenopausal or menopausal symptoms, hot flushes, night sweats, low libido, brain fog, anxiety, insomnia, hair thinning, acne, excess facial hair, fertility difficulties, recurrent miscarriage, chronic stress, burnout, or symptoms that persist despite previous partial hormone or thyroid testing.
Who Should Consider This Test?
- Persistent fatigue or exhaustion that does not improve with rest or sleep
- Unexplained weight gain or difficulty losing weight despite diet and exercise
- PMS, heavy, irregular, painful, or absent periods
- Breast tenderness, bloating, or mood changes in the second half of the cycle
- Perimenopausal or menopausal symptoms: hot flushes, night sweats, vaginal dryness, low mood
- Low libido or reduced sexual interest
- Brain fog, poor concentration, or memory issues
- Anxiety, irritability, or emotional volatility
- Insomnia, night waking, or unrefreshing sleep
- Hair thinning, dry skin, brittle nails, or feeling cold
- Acne, excess facial hair, or scalp hair loss
- Fertility difficulties or recurrent miscarriage
- Diagnosed or suspected PCOS, Hashimoto's thyroiditis, or oestrogen dominance
- Currently on HRT, the contraceptive pill, or thyroid medication and wanting a full hormonal picture
- Previous partial hormone or thyroid testing with inconclusive results
- Chronic stress, burnout, or sustained emotional exhaustion
- Women seeking the most comprehensive single at-home hormonal health assessment available
Why This Test Is Particularly Important for Women
- No other at-home test combines LCMS sex hormone accuracy with 4-point cortisol rhythm assessment and a full autoimmune thyroid panel in a single kit
- Cortisol is the master regulator of female hormonal balance - chronic stress suppresses progesterone via pregnenolone steal, drives oestrogen dominance, depletes DHEAS, impairs T4-to-T3 thyroid conversion, and disrupts the hypothalamic-pituitary axis; without the 4-point profile, the root cause of most female hormonal symptoms remains undetected
- Thyroid dysfunction is the most commonly missed driver of female hormonal symptoms - hypothyroidism, cortisol-driven T3 suppression, and Hashimoto's autoimmunity produce symptoms identical to sex hormone imbalance, and TSH alone misses the majority of clinically relevant thyroid dysfunction in women
- LCMS is the gold standard for bioavailable sex hormone measurement in women - measuring the free, bioavailable fraction that actually reaches cells and drives symptoms, unlike standard immunoassay blood tests which measure bound and inactive hormone
- All three oestrogens (E1, E2, E3) must be measured together - Estradiol alone does not reveal oestrogen metabolism, conversion pathways, or postmenopausal oestrogen dominance; the progesterone-to-oestrogen ratio is only calculable when both are measured simultaneously
Not Sure Which Test Is Right for You?
Email us at info@hormonelab.co.uk with your gender, age, symptoms, medications, and any current treatments. We will forward your enquiry to our doctors and respond within 24 hours.
How It Works
- Order your kit - delivered directly to your door
- Collect your saliva samples at four time points (morning before 9am, noon, evening, night) for the sex hormone and cortisol panel, and a finger-prick blood spot for the thyroid panel; guidance on optimal cycle timing is included
- Post your samples to ZRT Laboratory using the return instructions provided
- Receive your full report by email within 3-5 working days
What You Receive
- All 16 marker results with female-specific reference ranges
- Visual charts for all six sex hormones, your full 4-point cortisol daily curve, and thyroid panel values
- Clinical interpretation of how oestrogens, progesterone, testosterone, DHEAS, cortisol, and thyroid markers interact as an integrated system by a Hormone Specialist PhD Doctor
- Oestrogen-progesterone ratio and dominance pattern analysis
- Cortisol-thyroid interaction assessment - including whether cortisol is impairing T3 conversion
- Personalised next-step recommendations
- Laboratory fee included - no hidden charges
Why We Use ZRT Laboratory
All testing is performed by ZRT Laboratory - a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries.
- Pioneers of at-home dried blood spot (DBS) and saliva hormone testing
- Advanced LC-MS/MS technology for clinical-grade accuracy
- Qualified for the CDC Hormone Standardization (HoSt) Program
- Personalised reference ranges based on age and sex
Through our partnership with ZRT Laboratory, Hormone Lab UK delivers internationally recognised, research-backed hormone testing to people across the UK and Europe - from the comfort of home.
Frequently Asked Questions
What does this test measure?
Estradiol (E2), Estriol (E3), Estrone (E1), Progesterone, Testosterone, DHEAS (saliva LCMS) plus 4-point Cortisol (saliva: morning, noon, evening, night) plus TSH, Free T3, Free T4, Total T4, TPO Antibodies, and Thyroglobulin Antibodies (blood spot) - 16 markers in total.
Why is LCMS used for sex hormones in this test?
LCMS (Liquid Chromatography-Mass Spectrometry) is the most analytically precise method available for sex hormone measurement. It measures the free, bioavailable fraction of hormones in saliva - the portion actually reaching your cells and driving symptoms. Standard immunoassay blood tests measure total hormone including the bound, inactive fraction, which frequently masks the imbalances most relevant to symptoms in women.
When in my cycle should I collect my samples?
Guidance on optimal cycle timing is included in the kit. For most women, collection in the luteal phase (days 19-21 of a 28-day cycle) provides the most clinically meaningful progesterone and oestrogen values.
Can I use this test if I am on HRT, the contraceptive pill, or thyroid medication?
Yes. HRT and the pill significantly affect oestrogen, progesterone, and thyroid hormone binding - which is precisely why a comprehensive panel including LCMS bioavailable hormone measurement and full thyroid markers is more informative than standard blood tests for women on hormonal treatment. Follow the timing guidance in your kit.
Does the price include the laboratory fee?
Yes. The full laboratory analysis fee is included. There are no additional charges. You are only responsible for posting your samples to the laboratory.
How long is the kit valid for?
The kit must be used within 12 months of the purchase date.
