Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — menopause depression

What do heavy metals, neurotransmitters and hormone imbalances have in common? In this detailed case study, Dr. Kate Placzek examines Loretta — a 62-year-old postmenopausal woman with breast cancer — and shows how comprehensive testing can reveal the complex biochemical picture behind a cancer diagnosis. A compelling read for anyone interested in the role of hormones and toxic exposure in breast health.

Hot flushes, night sweats, anxiety, insomnia and brain fog — menopause can feel overwhelming. But what is actually happening biochemically? In this case study, Dr. Kate Placzek and Dr. Allison Smith walk through the test results of Julia, a newly postmenopausal woman, showing exactly how hormone and neurotransmitter imbalances drive menopausal symptoms — and what can be done about it.

In perimenopause, falling estradiol doesn’t just trigger hot flashes — it disrupts serotonin production, driving mood swings, brain fog and sleepless nights. Discover the hormonal science behind “the change” and how testing can help.

The Women’s Health Initiative (WHI) trial cast a long shadow over hormone replacement therapy — but it enrolled women well over a decade past menopause. Two newer trials, ELITE and KEEPS, specifically studied HRT started early in the postmenopausal period. Their findings on cardiovascular health, sexual function, sleep, mood and cognition paint a more nuanced and encouraging picture. Here is what the latest research shows.