Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — Estrogen Metabolism

By Tracy Tranchitella, ND, ZRT Laboratory The intricate interconnection between the human microbiome and the endocrine system highlights a significant communication network, wherein both systems profoundly influence one another. Particularly noteworthy is the relationship between estrogens and the gut microbiome. The estrobolome is the portion of the microbiome that influences estrogen metabolism. First defined in 2011, the estrobolome is the collection of all enteric bacteria capable of metabolizing estrogens (1). The estrobolome can impact endogenous estrogen metabolism by modulating the enterohepatic circulation of estrogens thus influencing plasma estrogen levels (2). Dysbiosis, diet, and gut infections can alter the microbial environment...

Single nucleotide variations (SNVs) in the enzymes that metabolise estrogen can significantly alter breast cancer risk — in some cases by as much as 12-fold when multiple variants combine. In this detailed scientific overview, Jillian Harrington PhD of ZRT Laboratory explains how variations in CYP11A1, CYP19A1 (aromatase), CYP1B1, COMT and MnSOD affect the estrogen metabolism pathway, why catechol estrogens are dangerous, and how methylation testing can reveal individual vulnerability.

What do heavy metals, neurotransmitters and hormone imbalances have in common? In this detailed case study, Dr. Kate Placzek examines Loretta — a 62-year-old postmenopausal woman with breast cancer — and shows how comprehensive testing can reveal the complex biochemical picture behind a cancer diagnosis. A compelling read for anyone interested in the role of hormones and toxic exposure in breast health.

Estrogen dominance — an excess of oestrogen relative to progesterone — is one of the most common hormonal imbalances in women. From heavy periods and mood swings to breast tenderness and weight gain, the symptoms are wide-ranging. Discover the causes, what to test, and how to restore balance.

One in eight women will be diagnosed with breast cancer in their lifetime. But many risk factors are modifiable — including hormone imbalance and excess weight. Discover the two most important actions women can take to reduce breast cancer risk, and how hormone testing can help identify hidden imbalances before they become a problem.