Female Comprehensive Hormone Profile II

Female Comprehensive Hormone Profile II – 14-Marker Blood Spot Test (Hormones + Full Thyroid Panel)

Test ID: B-243 | At-Home Blood Spot Collection | Results in 3–5 Working Days | Designed for Women

The Female Comprehensive Hormone Profile II is our most advanced women’s hormone blood spot test, measuring 14 essential markers across sex hormones, adrenal function, and a complete thyroid panel. Using highly accurate LC-MS/MS technology through our CLIA-certified partner, ZRT Laboratory, this test is ideal for women experiencing complex hormonal symptoms, perimenopause, menopause, thyroid dysfunction, fertility concerns, or chronic fatigue.

What Does This Test Measure?

Sex Hormones (8 Markers)

• Estrone (E1) – a post-menopausal oestrogen; elevated levels may indicate oestrogen dominance
• Estradiol (E2) – the primary reproductive oestrogen; key for cycle regulation, bone density, mood, and fertility
• Estriol (E3) – a weaker oestrogen that helps assess overall oestrogen balance, especially during perimenopause
• Progesterone (Pg) – essential for cycle balance, fertility, and counteracting oestrogen dominance
• Testosterone (T) – important for libido, energy, and muscle tone in women
• DHEA-S (DS) – an adrenal precursor hormone that declines with age; linked to vitality, mood, and immune function
• Cortisol (C) – the stress hormone; chronically elevated cortisol disrupts oestrogen and progesterone balance
• Sex Hormone Binding Globulin (SHBG) – regulates how much oestrogen and testosterone is biologically available

Full Thyroid Panel (6 Markers)

• Thyroid Stimulating Hormone (TSH) – the primary screening marker for thyroid function
• Free Triiodothyronine (fT3) – the active thyroid hormone; low fT3 is linked to fatigue, weight gain, and depression
• Free Thyroxine (fT4) – the storage thyroid hormone converted to fT3; key for assessing conversion issues
• Thyroid Peroxidase Antibody (TPOab) – elevated levels indicate autoimmune thyroid disease (Hashimoto’s)
• Thyroglobulin (Tgbn) – a marker for thyroid tissue health and autoimmune activity
• Total Thyroxine (TT4) – measures total thyroxine including protein-bound hormone

Who Is This Test For?

This test is ideal for women experiencing complex or overlapping symptoms that may involve both hormonal and thyroid imbalance, including:

• Persistent fatigue, morning or evening exhaustion
• Hot flashes, night sweats, or cold intolerance
• Irregular, heavy, or absent periods
• Mood swings, anxiety, depression, or tearfulness
• Brain fog, poor concentration, or increased forgetfulness
• Sleep disturbances or insomnia
• Weight gain or difficulty losing weight
• Low libido or vaginal dryness
• Hair loss, brittle nails, or thinning skin
• Bloating, acne, or oily skin
• Fertility concerns or irregular ovulation
• Bone loss or decreased muscle mass
• Heart palpitations, high cholesterol, or elevated triglycerides
• Sensitivity to chemicals or environmental allergens
• Swelling or puffiness around the eyes or face

Why Test Hormones and Thyroid Together?

Thyroid and sex hormones are deeply interconnected. Thyroid dysfunction can mimic or worsen hormonal imbalance symptoms — and vice versa. Many women are treated for one when the other is the root cause. Testing both systems together gives you and your doctor a complete clinical picture, avoiding misdiagnosis and enabling more targeted treatment.

Understanding Your Key Hormone Systems

Oestrogen & Progesterone Balance

The ratio of oestradiol to progesterone is one of the most clinically important indicators of hormonal health in women. Oestrogen dominance — where oestrogen is high relative to progesterone — is linked to PMS, fibrocystic breasts, endometrial hyperplasia, and uterine fibroids. During perimenopause and menopause, declining levels of both hormones cause hot flushes, night sweats, vaginal dryness, sleep disturbance, brain fog, accelerated skin ageing, and bone loss.

Testosterone & SHBG

Testosterone is essential for libido, energy, muscle tone, bone density, and psychological wellbeing in women. Low testosterone is common in women on hormonal contraception, post-menopause, or under chronic stress. SHBG regulates how much testosterone is biologically active — high SHBG can cause low-testosterone symptoms even when total testosterone appears normal.

DHEA-S & Adrenal Function

DHEA-S is produced by the adrenal glands and is a key precursor to both oestrogens and androgens. It peaks in early adulthood and declines steadily with age. Low DHEA-S is associated with fatigue, low mood, reduced immunity, and accelerated ageing. It is an important marker of adrenal reserve and overall hormonal vitality.

Cortisol & Stress Response

Cortisol follows a daily rhythm — highest in the morning, lowest at night. Chronically elevated cortisol, driven by prolonged stress, suppresses progesterone and disrupts the entire hormonal cascade. Long-term cortisol imbalance is linked to metabolic dysfunction, osteoporosis, cardiovascular disease, and cognitive decline.

Thyroid Function

Thyroid hormones regulate metabolism, energy, temperature, and mood. Hypothyroidism (underactive thyroid) is significantly more common in women and is frequently missed when only TSH is tested. This panel includes fT3, fT4, TPO antibodies, thyroglobulin, and TT4 — giving a complete picture of thyroid function and autoimmune activity (Hashimoto’s thyroiditis).

How Does the Test Work?

1. Order your kit – delivered directly to your door across the UK
2. Collect your sample at home – a simple finger-prick blood spot collection, no clinic visit required
3. Post your sample – send it to our ZRT Laboratory using standard post (shipping cost is your responsibility)
4. Receive your results – within 3–5 working days of the lab receiving your sample
5. Review your report – detailed hormone level graphics, numerical values, and specialist commentary from a PhD Hormone Specialist Doctor

👉 View a Sample Test Result Report

What’s Included in the Kit?

• Blood spot collection card
• Lancets for finger-prick sampling
• Full step-by-step instructions
• Laboratory fee (no additional lab costs or hidden charges)
• Valid for 12 months from purchase date

Why We Use ZRT Laboratory

All testing is performed by ZRT Laboratory — a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries.

• Pioneers of at-home dried blood spot (DBS) hormone testing
• Advanced LC-MS/MS and ICP-MS technology for clinical-grade accuracy
• Qualified for the CDC Hormone Standardization (HoSt) Program for testosterone and estradiol
• Personalised reference ranges based on age and sex

Through our partnership with ZRT Laboratory, Hormone Lab UK delivers internationally recognised, research-backed hormone testing to women across the UK and Europe — from the comfort of home.