Blog — Melatonin

By Dr Allison Smith, ZRT Laboratory.  I've been up to my elbows in melatonin research for a week now. I always felt like I had a pretty good working knowledge of where melatonin came from in the body, roughly how it was synthesized, the signals that propagate its production, and where it acts. Like most clinicians, I tended to think of it for sleep problems in general and as an adjunct treatment for some of the comorbidities associated with different cancers. I was also vaguely aware that there was a physical reason my colitis patients usually presented with depression and...

Melatonin is a ubiquitous little hormone that comes in an indolamine package similar to serotonin, its precursor. Thanks to its unique structure, it can travel easily through the blood stream and readily crosses the blood-brain and placental barriers. It is synthesized and used all over the body to perform a number of indispensable roles. It’s the main reason our bodies know what time it is and what it’s supposed to be doing at any given moment. It signals the transcription of genes that regulate the cell cycle, neutralize free radicals, and decrease inflammation. Its claim to fame, however, is its role in promoting sleep. Melatonin's Daily...