Advanced Neurotransmitter Test Kit (LCMS) | Specialist Interpretation Included

Gain Valuable Insights Into Your Brain Chemistry, Mood, Sleep, Focus and Emotional Wellbeing

Test ID: U-325  |  Sample Type: Dried Urine  |  Technology: Advanced LCMS analysis with specialist laboratory interpretation included.

The Advanced Neurotransmitter Test Kit is one of the most comprehensive at-home neurotransmitter tests available, measuring 26 neurotransmitters, metabolites, amino acid precursors, and related markers using advanced LC-MS (Liquid Chromatography Mass Spectrometry) technology.

Neurotransmitters are the chemical messengers that allow billions of nerve cells throughout the brain and nervous system to communicate with one another. They influence virtually every aspect of physical and mental wellbeing, including mood, stress response, motivation, concentration, memory, sleep quality, energy levels, emotional resilience, behaviour, and cognitive performance.

When neurotransmitters become imbalanced, the effects can extend far beyond mental health. Many individuals struggling with persistent fatigue, brain fog, anxiety, poor sleep, low motivation, mood swings, irritability, ADHD symptoms, or chronic stress may unknowingly have underlying neurochemical imbalances contributing to their symptoms.

This advanced neurotransmitter profile provides a detailed assessment of key neurotransmitter pathways, helping you and your healthcare practitioner gain a clearer understanding of how your nervous system may be functioning and identify areas that may benefit from personalised nutritional, lifestyle, or wellness interventions.

What Does the Neurotransmitters Test Measure?

Neuro Advanced Profile Includes:

Test Sample Report: Click to see >> Advanced Neurotransmitter Test Report

Why Is Neurotransmitter Testing Important?

Many symptoms associated with neurotransmitter imbalances can appear similar on the surface but may have very different underlying causes.

For example, two individuals may both experience anxiety, poor concentration, fatigue, and sleep disturbances. However, one person's symptoms may be associated with elevated excitatory neurotransmitters such as glutamate, while another may have reduced inhibitory neurotransmitter activity involving GABA or altered serotonin metabolism.

Without testing, treatment strategies often rely on assumptions or trial-and-error approaches.

Neurotransmitter testing provides objective data that may help identify patterns within the nervous system, allowing more informed decisions regarding diet, supplementation, lifestyle modifications, stress management, and other wellness strategies.

Rather than simply managing symptoms, testing may help uncover potential underlying neurochemical imbalances contributing to those symptoms.

What Are Neurotransmitters?

Neurotransmitters are naturally occurring chemical messengers responsible for transmitting signals between nerve cells throughout the brain and body.

They help regulate:

• Mood and emotional wellbeing
• Stress resilience
• Sleep quality
• Focus and concentration
• Memory and learning
• Motivation and reward pathways
• Energy production
• Behaviour and impulse control
• Cognitive performance
• Hormonal communication
• Nervous system regulation

Healthy neurotransmitter activity is essential for maintaining optimal brain and nervous system function.

Symptoms That May Be Associated With Neurotransmitter Imbalances

Many people experiencing ongoing symptoms struggle to identify the root cause of their health concerns.

Neurotransmitter imbalances may be associated with symptoms such as:

• Anxiety
• Panic attacks
• Low mood
• Depression-related symptoms
• Brain fog
• Poor concentration
• ADHD symptoms
• Hyperactivity
• Memory difficulties
• Chronic fatigue
• Low motivation
• Mood swings
• Irritability
• Emotional instability
• Insomnia
• Poor sleep quality
• Stress intolerance
• Impulsive behaviour
• OCD-related symptoms
• Low libido
• PMS and PMDD symptoms

While neurotransmitter testing is not intended to diagnose medical conditions, it can provide valuable information about neurochemical patterns that may contribute to these symptoms.

Conditions Commonly Associated With Neurotransmitter Imbalances

Research has shown that neurotransmitter dysfunction may play a role in a variety of health concerns, including:

• Anxiety disorders
• Depression
• ADHD
• Chronic stress
• Burnout
• Sleep disorders
• Cognitive dysfunction
• Mood disorders
• Fatigue-related conditions
• Hormonal imbalances
• Neurological conditions
• Emotional wellbeing challenges

Understanding neurotransmitter patterns may help support a more personalised and targeted approach to wellness.

Why This Test Is Different

Many neurotransmitter tests focus only on measuring parent neurotransmitters.

However, neurotransmitter activity is far more complex.

Measuring neurotransmitters alone may not reveal whether they are being effectively metabolised, converted, or broken down within the body.

This advanced profile evaluates both neurotransmitters and their downstream metabolites, providing a more comprehensive view of neurotransmitter pathways and overall neurochemical balance.

By examining these relationships, healthcare practitioners can often gain deeper insights than would be possible from neurotransmitter measurements alone.

Who Might Benefit From Neurotransmitter Testing?

This test may be useful for individuals experiencing:

• Anxiety or chronic stress
• Low mood
• Poor sleep
• Fatigue
• Brain fog
• ADHD symptoms
• Cognitive concerns
• Mood instability
• PMS or PMDD symptoms
• Low motivation
• Difficulty concentrating
• Emotional wellbeing concerns

It may also be valuable for those seeking a deeper understanding of their neurochemical health and nervous system function.

The Relationship Between Neurotransmitters, Hormones and Stress

Hormones and neurotransmitters work closely together.

Hormonal imbalances can influence neurotransmitter production and activity, while neurotransmitter imbalances can affect hormone signalling and stress responses.

This is why symptoms such as:

• Anxiety
• Mood changes
• Poor sleep
• Fatigue
• PMS
• Brain fog
• Low motivation

often involve both hormonal and neurotransmitter factors.

Many practitioners therefore choose to assess neurotransmitters alongside hormone testing to gain a broader understanding of a person's overall health picture.

Click to see Our Neurotransmitters and Hormone Tests

Environmental Factors That Can Influence Neurotransmitters

Neurotransmitter balance can be affected by many factors, including:

• Chronic stress
• Poor sleep
• Nutritional deficiencies
• Gut health imbalances
• Hormonal fluctuations
• Environmental toxins
• Heavy metal exposure
• Chronic inflammation
• Lifestyle habits

Testing may help identify patterns that support more personalised health recommendations.

Click to see our Neurotransmitters and Heavy Metals Test

Advanced LC-MS Technology

This test uses Liquid Chromatography Mass Spectrometry (LC-MS), one of the most advanced analytical technologies available for biological testing.

Benefits include:

• High analytical sensitivity
• Excellent specificity
• Reliable measurement of multiple markers
• Detailed neurochemical assessment
• Advanced laboratory analysis
• Professional interpretation

Convenient At-Home Collection

Unlike traditional 24-hour urine collections, this test uses four simple dried urine collections throughout the day.

Benefits include:

• Non-invasive sample collection
• No large urine containers
• Easy home collection
• Samples remain stable after drying
• Convenient postal return
• Suitable for adults and children

The collection process takes only a few minutes and can be completed from the comfort of your home.

Personalised Laboratory Report

Your comprehensive report includes:

• Graphical neurotransmitter results
• Individual marker values
• Reference ranges
• Metabolite analysis
• Specialist laboratory interpretation
• Personalised comments from experienced laboratory scientists

These insights may help support discussions with your healthcare practitioner regarding appropriate nutritional, lifestyle, or wellness strategies.

How the Test Works

Step 1 — Collect Samples at Home
Collect four dried urine samples at specific times during the day using the provided collection strips.

Step 2 — Send Samples to the Laboratory
Allow the samples to dry and return them to the laboratory using the provided instructions.

Step 3 — Receive Your Results
Your results will be emailed within 3–5 working days after the laboratory receives your samples.

Your report includes:

• Graphical neurotransmitter results
• Easy-to-read numerical values
• Specialist PhD laboratory comments
• Guidance on possible next steps

What Is Included in the Test Kit?

• Test requisition form
• Symptom checklist
• Collection instructions
• Dried urine collection strips
• Return envelope
• Shipping instructions

Important Information

• Laboratory fee included
• No hidden laboratory costs
• Customers are responsible for return shipping
• Test kit valid for 12 months from purchase date
• Free UK delivery included

Take The Guesswork Out Of Understanding Your Symptoms

When symptoms persist without clear answers, objective testing can provide valuable insight.

The Advanced Neurotransmitter Test Kit offers a detailed assessment of neurotransmitter pathways, helping you better understand your brain chemistry and identify potential factors that may be contributing to symptoms affecting your quality of life.

By combining advanced LC-MS technology, comprehensive neurotransmitter analysis, and specialist laboratory interpretation, this test provides one of the most detailed neurotransmitter assessments available for home use.

About Your ZRT Laboratory

Founded in 1998 by researcher Dr David Zava, ZRT Laboratory is a CLIA-certified laboratory and internationally recognised leader in hormone, neurotransmitter, wellness, and functional health testing. With more than 10 million tests performed and healthcare providers using its services in over 96 countries, ZRT is trusted worldwide for its scientific expertise and commitment to quality.

ZRT pioneered saliva and dried urine hormone testing and is the only specialty hormone laboratory to have qualified for the CDC Hormone Standardisation Program (HoSt) for Testosterone and Estradiol reference methods. The laboratory also participates in rigorous internal and external quality assurance programmes, including the Salivary Proficiency Inter-laboratory Testing (SPIT) programme, helping ensure exceptional accuracy and reliability.

Using advanced technologies including LC-MS/MS, ZRT provides comprehensive, easy-to-understand reports with expert laboratory interpretation to support informed health and wellness decisions.

Hormone Lab UK (Testfield UK Ltd) is the official UK test provider for ZRT Laboratory. All samples are analysed by ZRT Laboratory, a CLIA-certified laboratory with over 25 years of experience in hormone, neurotransmitter, and wellness testing.

Frequently Asked Questions (FAQs)

What is a neurotransmitter test?

A neurotransmitter test measures key chemical messengers involved in communication between nerve cells throughout the brain and nervous system. These neurotransmitters help regulate mood, sleep, focus, memory, stress response, energy levels, and emotional wellbeing. This advanced test evaluates 26 neurotransmitter-related markers using dried urine samples collected throughout the day.

What does the neurotransmitter test measure?

This comprehensive profile measures neurotransmitters, metabolites, amino acid precursors, and related markers including Dopamine, Serotonin, GABA, Glutamate, Norepinephrine, Epinephrine, Histamine, Phenethylamine (PEA), Glycine, Taurine, DOPAC, HVA, 5-HIAA, VMA, and additional markers involved in neurotransmitter production and metabolism.

Why should I test my neurotransmitters?

Neurotransmitter imbalances may be associated with symptoms such as anxiety, low mood, brain fog, fatigue, poor concentration, sleep disturbances, stress-related symptoms, ADHD-related symptoms, mood swings, and reduced motivation. Testing provides objective information about your neurochemical profile and may help guide personalised wellness strategies.

Can neurotransmitter imbalances cause anxiety?

Research suggests that neurotransmitters such as GABA, Glutamate, Serotonin, Norepinephrine, Histamine, and Dopamine play important roles in regulating stress responses and emotional wellbeing. Imbalances in these pathways may be associated with anxiety-related symptoms in some individuals.

Can neurotransmitter imbalances contribute to depression symptoms?

Neurotransmitters including Serotonin, Dopamine, Norepinephrine, and Phenethylamine (PEA) are involved in mood regulation and emotional wellbeing. Testing may help identify patterns that could contribute to low mood and other emotional health concerns.

Can this test help identify causes of brain fog and poor concentration?

Brain fog, reduced focus, memory difficulties, and concentration problems may be associated with multiple factors including neurotransmitter imbalances, stress, poor sleep, hormonal changes, nutritional deficiencies, and lifestyle factors. This test provides information that may help uncover potential neurochemical contributors.

Is neurotransmitter testing useful for ADHD symptoms?

Neurotransmitters such as Dopamine, Norepinephrine, GABA, and Serotonin play important roles in attention, focus, motivation, impulse control, and executive function. While this test cannot diagnose ADHD, it may provide useful information regarding neurotransmitter patterns associated with attention and concentration challenges.

Can neurotransmitter imbalances affect sleep?

Yes. Neurotransmitters such as GABA, Glutamate, Serotonin, Histamine, Dopamine, and Norepinephrine are closely involved in sleep regulation and circadian rhythms. Imbalances may be associated with insomnia, difficulty falling asleep, restless sleep, or waking during the night.

Can neurotransmitter testing help with chronic fatigue?

Neurotransmitters influence energy production, motivation, mental clarity, and stress resilience. Imbalances between excitatory and inhibitory neurotransmitters may contribute to fatigue-related symptoms and reduced mental performance.

How accurate is LC-MS neurotransmitter testing?

This test uses Liquid Chromatography Mass Spectrometry (LC-MS), one of the most advanced laboratory technologies available for biological testing. LC-MS offers high sensitivity, specificity, and accuracy when measuring neurotransmitters and related metabolites.

Why does this test measure neurotransmitter metabolites?

Measuring neurotransmitters alone does not always provide a complete picture. Metabolites help assess how neurotransmitters are being produced, converted, and broken down within the body. This additional information may help provide a more comprehensive understanding of neurotransmitter function.

How are samples collected?

Samples are collected using dried urine collection strips at four specific times throughout the day. The strips are allowed to dry before being returned to the laboratory for analysis.

Why are four samples collected during the day?

Neurotransmitter activity can fluctuate throughout the day. Collecting multiple samples provides a broader assessment of neurochemical activity compared to a single spot sample.

Is the test suitable for children?

Yes. The dried urine collection method is non-invasive and suitable for adults and children.

Do I need to visit a clinic?

No. The test is designed for convenient at-home collection. Everything required for sample collection is included within the test kit.

How long does it take to receive results?

Results are typically available within 3–5 working days after the laboratory receives your samples.

Can neurotransmitter testing diagnose medical conditions?

No. This test is not intended to diagnose, treat, cure, or prevent any disease. It provides information about neurotransmitter-related biomarkers that may help support discussions with healthcare practitioners regarding symptoms and overall wellbeing.

Should neurotransmitters be tested alongside hormones?

Many practitioners find that testing hormones and neurotransmitters together provides a more complete picture of health because hormonal balance can influence neurotransmitter production, metabolism, mood, sleep, stress response, and cognitive function.

Can environmental factors affect neurotransmitters?

Yes. Chronic stress, poor sleep, nutritional deficiencies, hormonal changes, gut health, inflammation, environmental toxins, and heavy metal exposure may all influence neurotransmitter production and activity.

What makes this neurotransmitter test different?

This advanced profile measures 26 neurotransmitter-related markers, including neurotransmitters, metabolites, and precursors using LC-MS technology. By evaluating both neurotransmitters and their downstream metabolites, it provides a more comprehensive assessment of neurochemical function than many standard neurotransmitter tests.