Test ID: SU-840 | Sample Type: Saliva + Dried Urine | Technology: LC-MS | Laboratory: ZRT Laboratory, CLIA-certified | Specialist Laboratory Interpretation: Included | Results: 3–5 working days after the laboratory receives your samples | Suitable For: Children and Adults | Collect Sample At Home: No Clinic Visit Required
If tiredness, mood changes, poor sleep, brain fog or reduced libido are affecting everyday life, this combined kit provides hormone and neurotransmitter-related measurements to explore with your practitioner. It can also add useful information when these concerns overlap with menstrual changes or menopausal symptoms.
The Advanced Neurotransmitter & Saliva Hormone Test I combines seven saliva hormone measurements with the Advanced 26-marker urinary neurotransmitter profile. The saliva panel measures Estradiol, Estriol, Estrone, progesterone, testosterone, DHEA-S and morning cortisol. The urinary panel measures selected neurotransmitters, amino acid precursors, metabolites and creatinine.
Your report brings both sets of results together, with reference ranges, numerical and graphical values, and specialist laboratory interpretation to help you discuss appropriate next steps.
What Does the Combined Neurotransmitter and Saliva Hormone Test Measure?
The kit includes seven saliva hormone measurements and 26 urinary markers, giving 33 measurements in total.
Saliva Hormone Profile Includes:
| Estradiol (E2) Test | Estriol (E3) Test |
| Estrone (E1) Test | Progesterone (Pg) Test |
| Testosterone (T) Test | DHEA-S (DS) Test |
| Morning Cortisol (C) Test |
Neuro Advanced Profile Includes:
| Gamma-aminobutyric acid (GABA) Test | Glutamate (Glu) Test |
| Glycine (Gly) Test | Dopamine (DA) Test |
| Epinephrine / Adrenaline (Epi) Test | Norepinephrine / Noradrenaline (NE) Test |
| Histamine (HIST) Test | Serotonin (5-HT) Test |
| Phenethylamine (PEA) Test | DOPAC Test |
| Homovanillic Acid (HVA) Test | 5-HIAA Test |
| Normetanephrine (NMN) Test | Vanillylmandelic Acid (VMA) Test |
| Tryptophan (Trp) Test | Kynurenine (Kyn) Test |
| Kynurenic Acid (KynAc) Test | 3-Hydroxykynurenine (3-OHKyn) Test |
| Xanthurenic Acid Test | Taurine Test |
| Glutamine Test | Histidine Test |
| N-Methylhistamine Test | Tyrosine Test |
| Tyramine Test | Creatinine (Crtn) Test |
Creatinine is included in the 26-marker profile to help account for urine concentration.
Not Sure Which Test Is Right for You?
Email info@hormonelab.co.uk with your age, gender, symptoms, medications, supplements, current treatments and questions. We will forward your enquiry to our doctors and aim to respond within 24 hours with a test suggestion.
Could This Test Help You Explore Your Symptoms?
Hormones and nervous-system signalling are involved in mood, sleep, energy, concentration and sexual wellbeing. This combined profile provides two complementary sets of laboratory information, particularly useful for discussion when several concerns occur together.
Persistent Tiredness or Fluctuating Energy
Do you feel tired despite getting enough sleep, or find your energy rises and falls during everyday activities?
Markers assessed include:
- Morning Cortisol
- DHEA-S
- Testosterone
- Dopamine
- Norepinephrine
- Epinephrine
- Phenethylamine (PEA)
How this test may help: Morning saliva cortisol, DHEA-S and testosterone provide hormone measurements to review alongside tiredness or reduced stamina. The urinary profile adds information when energy concerns overlap with low motivation, poor concentration or stress.
Low Mood, Irritability or Frequent Mood Changes
Mood changes can affect relationships, motivation and everyday wellbeing, and may overlap with menstrual or menopausal concerns.
Markers assessed include:
- Estradiol (E2)
- Estriol (E3)
- Estrone (E1)
- Progesterone
- Serotonin
- Dopamine
- GABA
- Tryptophan
- Kynurenine Pathway Markers
How this test may help: The saliva results provide hormone measurements, while the urine results add selected neurotransmitters, precursors and metabolites. Reviewing both sets together offers broader laboratory information when emotional changes occur alongside sleep, energy or reproductive-health concerns.
Feeling Anxious, Tense, Overwhelmed or Unable to Switch Off
Feeling constantly alert, tense or unable to relax can affect sleep, work and daily life.
Markers assessed include:
- Cortisol
- GABA
- Glutamate
- Glycine
- Serotonin
- Norepinephrine
- Epinephrine
How this test may help: The panel combines morning saliva cortisol with urinary neurotransmitter-related measurements. These findings add laboratory information to a review of tension and difficulty unwinding, alongside your routine, symptoms and current treatments.
Poor Concentration, Forgetfulness or Brain Fog
Difficulty focusing, reduced mental clarity and forgetfulness can affect everyday performance and quality of life.
Markers assessed include:
- Dopamine
- Norepinephrine
- Serotonin
- Glutamate
- Tyrosine
- Tryptophan
- Kynurenine Pathway Markers
- Estradiol
How this test may help: Urinary compounds, precursors and metabolites provide additional information for a discussion about concentration concerns. The saliva profile adds hormone results when brain fog occurs alongside menstrual changes, menopausal symptoms or changes in energy.
Difficulty Falling Asleep, Staying Asleep or Waking Refreshed
Trouble switching off, frequent waking or unrefreshing sleep can affect both daytime energy and mood.
Markers assessed include:
- Cortisol
- Serotonin
- GABA
- Glycine
- Glutamate
- Histamine
- Taurine
How this test may help: Morning cortisol and urinary neurotransmitter-related results add information to review alongside your sleep pattern and routine. The broader hormone panel is useful for discussion when sleep changes occur with night sweats, menstrual changes or reduced wellbeing.
Reduced Motivation or Enjoyment
Loss of drive, enthusiasm or enjoyment can affect work, relationships and overall wellbeing.
Markers assessed include:
- Dopamine
- DOPAC
- HVA
- Phenethylamine (PEA)
- Tyrosine
- Testosterone
- DHEA-S
How this test may help: Dopamine is measured alongside its urinary metabolites and the precursor tyrosine. Testosterone and DHEA-S add hormone information to discuss when low motivation overlaps with tiredness or changes in sexual wellbeing.
Low Libido or Changes in Sexual Wellbeing
Reduced sexual desire can occur alongside changes in mood, energy, relationships or stress.
Markers assessed include:
- Testosterone
- DHEA-S
- Estradiol
- Progesterone
- Dopamine
- Serotonin
How this test may help: The saliva profile provides selected hormone measurements to review alongside reduced libido and any hormone treatments. The urinary profile adds information when sexual wellbeing concerns overlap with changes in mood, motivation or sleep.
Menstrual Changes, PMS or Premenstrual Mood Symptoms
Cycle-related irritability, emotional sensitivity and changes in wellbeing can make some days feel harder than others.
Markers assessed include:
- Estradiol
- Estriol
- Estrone
- Progesterone
- Serotonin
- Dopamine
- GABA
How this test may help: The saliva results provide estrogen and progesterone measurements to review alongside your symptoms and cycle stage. The urinary profile adds information when menstrual concerns occur with changes in mood, sleep or concentration. Follow the cycle-timing guidance so your practitioner can review the results in the appropriate context.
Hot Flushes, Night Sweats or Vaginal Dryness
These concerns can occur during perimenopause and menopause, sometimes alongside changes in sleep and emotional wellbeing.
Markers assessed include:
- Estradiol
- Estriol
- Estrone
- Progesterone
- DHEA-S
- Selected urinary neurotransmitters and related compounds
How this test may help: The saliva results provide measurements of Estradiol, Estriol, Estrone and progesterone to review alongside your symptoms, cycle stage and any hormone treatment. The urinary profile adds information when these concerns occur with changes in mood, sleep or concentration.
Changes in Weight or Body Composition
Changes in weight or body composition may occur alongside tiredness, reduced activity or changes in wellbeing.
Markers assessed include:
- Cortisol
- Estradiol
- Progesterone
- Testosterone
- DHEA-S
- Dopamine
How this test may help: Selected hormone and urinary neurotransmitter-related measurements add information to a broader review when body-composition concerns overlap with changes in energy, mood or motivation. Your practitioner can discuss these findings alongside diet, activity and health history.
Reduced Strength, Stamina or Muscle Mass
Reduced stamina, slower recovery or changes in strength can affect exercise and everyday activities.
Markers assessed include:
- Testosterone
- DHEA-S
- Cortisol
How this test may help: These saliva hormone measurements provide information to discuss alongside changes in physical wellbeing, activity levels and recovery. The combined report is particularly useful for discussion when these concerns occur with tiredness or reduced motivation.
Difficulty Coping With Everyday Stress
Some people feel mentally and physically exhausted by everyday stressors, while others feel constantly “wired” and find it difficult to unwind.
Markers assessed include:
- Cortisol
- DHEA-S
- Epinephrine
- Norepinephrine
- GABA
- Serotonin
How this test may help: Morning saliva cortisol and DHEA-S are reviewed alongside urinary neurotransmitter-related measurements. Bringing these findings together can make your consultation more focused when stress concerns overlap with disturbed sleep, tiredness or emotional changes.
Why Test Hormones and Neurotransmitters Together?
Hormonal and nervous-system signalling interact and are involved in mood, sleep, energy and sexual wellbeing. The saliva profile provides selected reproductive and adrenal hormone measurements. The urinary profile provides a separate set of neurotransmitter-related measurements.
Combining both panels gives your practitioner broader laboratory information within one report, rather than considering either set of results in isolation.
The urinary panel measures parent neurotransmitters alongside related metabolites, including dopamine with DOPAC and HVA, serotonin with 5-HIAA, and histamine with N-methylhistamine. Reviewing related compounds together provides a broader biochemical picture than considering individual markers alone.
What Are Neurotransmitters and the Hormones Included in This Panel?
Neurotransmitters are chemical messengers that help nerve cells communicate. This urinary profile measures selected neurotransmitters and related compounds excreted by the body.
The saliva profile includes three estrogens, progesterone, testosterone, DHEA-S and morning cortisol. Your practitioner can review these measurements alongside your age, sex, cycle stage where applicable and current hormone treatments.
Choosing Between Related Panels
SU-840 combines the Advanced urinary profile with seven saliva hormones, including one morning cortisol measurement. The 36-marker Saliva Hormone Test II extends saliva cortisol testing to four collection times.
The 49-marker SU-841 kit combines seven saliva hormones with timed urinary cortisol, cortisone and melatonin-metabolite measurements. The 57-marker Elite kit further extends that urinary combination with additional norepinephrine and epinephrine measurements.
Saliva and Dried Urine Collection Instructions
Collect your samples at home using the materials provided in your SU-840 kit. This panel requires one morning saliva sample and four dried urine samples. Saliva and urine samples can be collected on separate days.
Before You Begin
Read the full instructions supplied with your kit. Record all current medications, supplements and hormone treatments on your Test Requisition Form.
- Three days before collection: Avoid anti-ageing or anti-wrinkle facial creams and biotin (vitamin B7), including hair and nail supplements.
- The day before and the day of testing: ZRT recommends avoiding bananas, pineapple, nuts, nut butters, alcohol, nicotine, protein powders and protein shakes.
- Before saliva collection: Do not eat, drink anything other than water, or brush your teeth before the morning sample.
Choosing Your Collection Day
Men, children and women who do not menstruate: Collect on any day of the month. If you use hormone treatments, also follow the guidance below.
Women with regular periods: For saliva hormone testing, choose your collection day according to your usual cycle length. Day 1 is the first day of menstrual flow, rather than spotting.
| Usual Cycle Length | Saliva Collection Day |
|---|---|
| 23–26 days | Day 17, 18 or 19 |
| 27–30 days | Day 21, 22 or 23 |
| 31–34 days | Day 25, 26 or 27 |
| Shorter or longer cycles | 5–7 days before your next expected period |
Women with irregular or infrequent periods: Collect on any non-bleeding day.
For dried urine collection: Avoid menstruation or any time blood could enter your urine sample. Urine collection does not require a specific menstrual-cycle day.
Saliva Collection Timing
For SU-840, collect one morning saliva sample. Begin collection within 30 minutes of waking, using the large 10 ml tube supplied with your kit.
How to Collect Saliva
- Wash your hands with soap and water and dry them with a clean towel.
- Rinse your mouth with water, then wait five minutes.
- Allow saliva to pool in your mouth and transfer it into the tube. Fill the tube at least halfway, excluding bubbles. Collection usually takes 15–30 minutes.
- Screw the cap on securely.
- Write your name, collection date and time on the tube label, then return the tube to its bag.
If you make a collection mistake, rinse the tube with hot water without soap, shake out the remaining water and allow it to air-dry before restarting at the appropriate time.
Freeze saliva samples if they will not be shipped within 24 hours.
Dried Urine Collection Timing
Collect four urine samples:
| Sample | Collection Time |
|---|---|
| 1 | Your first urination immediately upon waking |
| 2 | Your second urination, approximately two hours after the first collection |
| 3 | Just before dinner |
| 4 | Just before bedtime |
Before the first urine collection, do not eat, drink anything other than water, or take vitamins or supplements. Follow your healthcare provider’s advice about medication timing.
Limit fluid intake to no more than approximately 240 ml (8 oz) during the hour before each urine collection to avoid diluting your sample.
How to Collect Dried Urine
- Remove a collection card from its bag and write your name, collection date and time on it.
- Open the cover and fold it away from the filter paper. Avoid touching the filter paper.
- Fully saturate the paper by urinating directly onto it, or collect urine in a clean cup and dip the paper up to the top black dashed line.
- Hang or tape the card somewhere secure, ensuring the wet paper does not touch anything.
- Allow it to dry completely for at least six hours. Once dry, refold the card, place it in its bag and seal it. Do not leave samples outside the bag for longer than 24 hours.
- Repeat for each collection time.
Missed a urine collection? Collect that sample at the same time the following day. Record the actual date and time on the card and Test Requisition Form.
If You Use Hormone Treatments
Record all hormone treatments on your form. Do not stop prescribed treatment without your healthcare provider’s advice.
- Topical or oral hormones: Follow the kit’s timing instructions. The previous evening’s dose should generally be at least 12 hours before morning collection; oral progesterone may be taken at bedtime.
- Prevent contamination: Use gloves or an applicator for topical hormones for at least two days before collection. Avoid applying hormones to your face, lips or neck. Change sheets, pillowcases and towels the night before collection and avoid surfaces that may contain hormone residue.
- Patches, vaginal rings, pellets or injections: Follow the laboratory’s guidance to collect halfway between doses.
- Troches or sublingual hormones: The laboratory does not recommend saliva testing with these therapies. Discuss blood spot testing with your healthcare provider.
- 7-Keto DHEA: The laboratory advises avoiding it for three days before collection. This does not apply to regular DHEA.
- Steroid medicines: Ask your healthcare provider about appropriate collection timing.
- On the urine collection day: Take your morning hormone dose after the first urine sample and wash your hands thoroughly. Collect the bedtime sample before nighttime hormones. The laboratory advises avoiding vaginal hormone use until after the final urine sample; discuss any timing adjustment with your healthcare provider.
Returning Your Samples
Complete the Test Requisition Form in full. Place all labelled samples, the completed form and any additional paperwork into the test kit box. Ensure urine cards are completely dry and sealed, then return the kit according to the supplied return instructions.
A return envelope is provided with your kit. It is not prepaid; customers are responsible for return postage to the laboratory.
Important: Urine samples that are wet, unsealed, excessively diluted or more than 30 days old will not be processed, replaced or refunded.
Read the full laboratory collection instructions.
Advanced LC-MS Technology
The kit uses LC-MS laboratory analysis for its combined profile. Specialist laboratory interpretation accompanies the results to help explain the findings.
Convenient At-Home Collection
Collect one morning saliva sample and four timed dried urine samples using the supplied materials. No blood draw or clinic visit is required. Follow the preparation, collection and storage instructions carefully.
How the Test Works
- Order your kit and receive the collection materials.
- Choose your collection day according to the supplied hormone-testing guidance.
- Collect one morning saliva sample and four timed dried urine samples.
- Prepare, package and return the samples according to the kit instructions.
- Receive your results by email, normally within 3–5 working days after the laboratory receives your samples.
What You Receive With Your Results
Your report includes all 33 measurements, numerical and graphical results, laboratory reference ranges, saliva hormone results and urinary neurotransmitter-related results with specialist commentary.
Share the combined report with your practitioner alongside your symptoms, cycle stage where applicable and treatment history. Use the interpretation to prepare questions and discuss appropriate next steps.
Kit Fees, Postage and Validity
Laboratory analysis and specialist interpretation are included. A return envelope is provided with your kit. It is not prepaid; customers are responsible for return postage to the laboratory. Use the kit within 12 months of purchase.
Record all medicines, supplements and hormone treatments on the requisition form.
About ZRT Laboratory
All testing is performed by ZRT Laboratory, a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries.
- Pioneers of at-home dried urine neurotransmitter and hormone testing
- Advanced LC-MS/MS technology for clinical-grade accuracy
- Qualified for the CDC Hormone Standardisation (HoSt) Program
- Rigorous internal and external quality assurance programmes
Hormone Lab UK (Testfield UK Ltd) is the official UK test provider for ZRT Laboratory. All samples are analysed by ZRT Laboratory, a CLIA-certified laboratory with over 25 years of experience in hormone, neurotransmitter, and wellness testing.
Frequently Asked Questions
How can this combined test help me explore my symptoms?
It brings saliva hormone and urinary neurotransmitter-related measurements together in one report. This provides broader laboratory information for discussion when mood, sleep, energy, concentration or sexual wellbeing concerns overlap.
Which saliva hormones are included?
Estradiol, Estriol, Estrone, progesterone, testosterone, DHEA-S and morning cortisol.
What does the urinary profile add?
It measures selected neurotransmitters alongside related metabolites and amino acid precursors. These findings complement the saliva hormone results when preparing a focused consultation about your symptoms.
How can the results support a discussion about menopausal symptoms?
The estrogen and progesterone measurements provide information to review alongside symptoms, cycle stage and hormone treatment. The urinary profile adds information when these concerns occur with changes in sleep, mood or concentration.
Can the report be useful for PMS or premenstrual mood concerns?
It provides reproductive hormone measurements alongside urinary neurotransmitter-related findings. Review these with your practitioner and a symptom diary, following the cycle-timing instructions for saliva collection.
How can the results support a discussion about low libido?
Selected hormone results, including testosterone, DHEA-S, Estradiol and progesterone, provide information to review alongside sexual wellbeing concerns. The urinary findings add context when these concerns overlap with mood, motivation or energy changes.
How can the report help with tiredness or brain fog?
Morning cortisol, DHEA-S and the wider hormone profile provide one set of measurements, while urinary neurotransmitters and related compounds provide another. Your practitioner can review both with your sleep, routine and symptom history to discuss next steps.
How many samples do I collect?
One morning saliva sample and four timed dried urine samples. Follow the SU-840 instructions supplied with your kit.
Which kit offers more detailed daily saliva cortisol measurements?
The 36-marker Saliva Hormone Test II includes cortisol measured at four saliva collection times alongside the same other saliva hormones and Advanced urinary neurotransmitter profile. SU-840 includes one morning saliva cortisol measurement.
Which panels add daily urinary hormone and melatonin-metabolite measurements?
The 49-marker SU-841 kit adds timed urinary cortisol, cortisone and MT6s to the saliva hormones and Advanced urinary profile. The 57-marker Elite kit further adds timed norepinephrine and epinephrine measurements.
When should I collect if I have regular periods?
Choose the saliva collection day according to your usual cycle length using the table above. Day 1 is the first day of menstrual flow. Collect urine on a non-bleeding day.
Can saliva and urine be collected on separate days?
Yes. Record the date and time of every sample and follow the preparation and storage guidance for each sample type.
What if I use HRT, testosterone or another hormone treatment?
Record all treatments and follow the laboratory’s timing and contamination instructions. Ask your prescriber about any timing adjustment; do not change prescribed treatment without their advice.
How should I store my samples?
Freeze saliva if it will not be shipped within 24 hours. Allow urine cards to dry completely for at least six hours before sealing them. Follow the full laboratory instructions.
Is this test suitable for children and adults?
The saliva and dried urine collection methods are non-invasive and suitable for children and adults.
Do I need to visit a clinic?
No. Collect Sample At Home: No Clinic Visit Required. Use the supplied saliva tube and dried urine collection cards.
What do I receive with my results?
A combined report covering all 33 measurements, with numerical and graphical results, reference ranges and specialist laboratory interpretation.
How can I use my report?
Share it with your practitioner alongside your symptoms, collection dates, medicines, supplements and hormone treatments. Use the interpretation to prepare questions about the findings and discuss appropriate further assessment or nutrition, lifestyle and wellbeing steps.
When will I receive my results?
Results are normally emailed within 3–5 working days after the laboratory receives your samples.
Are laboratory fees included?
Yes. Laboratory analysis and specialist interpretation are included.
Is the return envelope prepaid?
No. A return envelope is supplied, but customers pay return postage to the laboratory.
How long is the kit valid for?
Use the kit within 12 months of purchase.
