Neuro Advanced Profile + Cortisol, Cortisone & Melatonin Hormones in dried urine containing the following 42 tests:Gamma-aminobutyric acid (GABA),Glutamate (Glu),Glycine (Gly),Dopamine (DA),Epinephrine (Epi),Norepinephrine (NE),Histamine (HIST),Serotonin (5-hydroxytryptophan (5-HT),Phenethylamine (PEA),Dopamine metabolite's (DOPAC),Homovanillic acid (HVA),5-hydroxyindole 3-acetic acid (5-HIAA),Vanillylmandelic acid (VMA),Creatinine (Crtn),Tryptophan,Kynurenine,Kynurenic acid,3-Hydroxykynurenine,Xanthurenic acid,Taurine,Glutamine,Histidine,N-Methylhistamine,Tyrosine,Tyramine.
Free Cortisol (FCx4),Free Cortisone (FCnx4),Creatinine (Crtnx4),Melatonin (MT6sx4).
Test Result: You will receive your test result 3-5 working days after the laboratory receives your sample. You will see your hormone levels in graphics and numbers on your test result. You will also see laboratory comments by Hormone Specialist PhD Dr in the comments: you will find Dr analysis of your hormone levels and what to do next.
- Collect samples from the comfort of your home and post them to our lab.
- The test must be used within 12 months after the purchase date.
- The test kit includes a laboratory fee: no additional laboratory cost and tax.
- Customers are responsible for shipping their samples to the laboratory.
NEUROTRANSMITTERS PLAY A KEY ROLE in mental conditions, such as depression & anxiety, can occur when neurotransmitter levels are out of balance.
ARE YOU AFFECTED? Just a few causes of suboptimal neurotransmitter levels are stress, diet, toxins, drugs, alcohol & nicotine.
NEUROTRANSMITTERS & YOUR HEALTH
- Do you suffer from anxiety or depression?
- Do you struggle to fall asleep or stay asleep throughout the night?
- Men, has your libido fizzled?
- Women, do you dread the weeks before your period?
If you answered yes to these questions, an underlying neurotransmitter imbalance may be the cause. Simple testing may help you find personalized solutions.
Neurotransmitters & Their Impact
Neurotransmitters are chemical messengers used by the nervous system to relay information from one nerve to another.
The body relays information through the nervous system about anything that it experiences, hears, touches smells, or ingests – continuously communicating back and forth between the brain and the body.
Optimal neurotransmitter balance is required to maintain proper health. Imbalances can cause the brain and the body to be over-or understimulated, producing neurological or psychological symptoms.
Can a Dysregulated Nervous System Impact Health?
Like hormones, neurotransmitters require a delicate balance to keep the body functioning at a peak level.
Genetics, environment, chemicals, and nutritional deficiencies are a few factors that can result in over-or under-production of neurotransmitters. Once out of balance, the nervous system begins to compensate – which, in time, can lead to neurological or psychological symptoms.
Some of the more common psychological conditions today are known to be accompanied by neurotransmitter imbalances. However, it’s also possible for individuals to present with similar symptoms yet have unique foundational imbalances. Testing helps clarify these root issues.
Do These Symptoms Sound Familiar?
If you regularly suffer from 3 or more of these symptoms, you might have a neurotransmitter imbalance.
- Impulsive behaviours
- Low libido
- Mood swings
- Obsessive-compulsive disorder (OCD)
- Panic attacks
- Poor concentration
- Pre-menstrual dysphoric disorder (PMDD)
- Severe PMS
- Sleeping problems
Neurotransmitters You Should Know
There are many neurotransmitters in the body. The primary messengers are divided into two groups.
- Dopamine, generally regarded as the brain’s pleasure and reward center, plays the central role in addiction, improves attention, focus and motivation, and modulates movement control.
- Epinephrine and Norepinephrine regulate the “fight or flight” response, elevate blood pressure and heart rate, stimulate wakefulness and reduce digestive activity.
- Glutamate functions as the “on” switch in the brain. It’s the major excitatory neurotransmitter that decreases sleep, optimizes learning, memory, and mood, and improves libido.
- Histamine plays a role in the body as a neurotransmitter that increases metabolism, promotes wakefulness, and suppresses appetite.
- PEA (phenylethylamine) promotes energy, elevates mood, regulates attention, aggression and serves as a biomarker for ADHD.
- GABA functions as the “off” switch in the brain. It’s the major inhibitory neurotransmitter that improves mood, relieves anxiety, and promotes sleep.
- Glycine plays a dual role as a neurotransmitter and amino acid that serves as a building block to proteins, improves sleep quality, calms aggression, and serves as an anti-inflammatory agent.
- Serotonin, generally regarded as the “happiness molecule,” contributes to the feeling of calm and well-being that eases depression and anxiety, supports sleep, and decreases appetite.
Neurotransmitter Imbalance & Chronic Conditions
Numerous neurotransmitter imbalances may cause persistent health concerns:
- Anxiety & Depression: Imbalances are often associated with Glutamate (panic attacks), PEA, Histamine, Serotonin, as well as Epinephrine and Norepinephrine.
- Fatigue: An imbalance between excitatory and inhibitory neurotransmitters is likely.
- Impulsivity: GABA, Dopamine, and Serotonin are three chemical messengers commonly linked to disorders like ADD, ADHD, and OCD.
- Insomnia: Glutamate, Histamine, Dopamine, GABA, and Serotonin are several chemical messengers often linked to sleep disturbances and insomnia.
- PMS or PMDD: Imbalances such as Serotonin, Dopamine, Norepinephrine, and GABA are often involved
Neurotransmitter Testing – Giving a Diagnostic Edge in Treating Mood Disorders.
Mental health disorders affect millions of people and profoundly contribute to the burden of disease in society.
The current treatment paradigm in addressing poor brain health relies on diagnostic tools that encompass the evaluation of clinical signs and symptoms. Despite the lack of testable biomarkers for mood disorders, for many patients, treatments can generally be effective. However, even after treatment frequent relapse episodes can still occur. Furthermore, a large number of patients suffer from treatment-resistant depression. Therefore, the selection of the best therapeutic regimen for each patient remains a challenge and is often discovered through a time-consuming process of trial and error. Also, no single approach works for everyone with any one disorder.
Targeted neurotransmitter testing can help health care practitioners achieve a diagnostic edge beyond the traditional psychological inventory by identifying specific imbalances in neurotransmitter levels. Based on neurotransmitter test results, practitioners can identify specific biochemical heterogeneities for each particular patient, and objectively monitor therapeutic responses during and after the intervention. Neurotransmitter testing objectively enhances medical assessment and represents a major advance in the personalization of the treatment of mood disorders.
How Neurotransmitters Relay Information within the Body
The brain orchestrates the delicate interplay between the body and the mind. Structural brain units, the neurons, discharge neurotransmitters. These neurotransmitters provide a communication platform for the brain to fuel internal systems with information. Anything the body senses, feels, hears, smells, touches, or ingests serves as an input that prompts an astoundingly fast response. In the central and peripheral nervous system, neurotransmitters operate as chemical messengers that relay the signal and receive feedback via electrochemical impulses to regulate cognition, memory, emotions, respiration, heart rate, and contractility, digestion, metabolism, blood flow, and pressure, and hormonal responses. When released from peripheral organs, neurotransmitters can also behave as hormones by diffusing to distant sites via the circulation.
Clinical Utility of Urinary Neurotransmitter Analysis
The etiology of mood disorders is profoundly complex and likely encompasses many different types of neurotransmitters, how they achieve balance in the brain and in the gut axis, and how they each interplay with other hormone systems throughout the body. Appropriate balancing of neurotransmitter signals allows the body to maintain equilibrium. When the brain and peripheral neurochemistry become unbalanced, the body will struggle to re-establish physiological integrity, which may present in the form of suboptimal psychological well-being. Excessive or deficient levels of certain neurotransmitters in both the brain and in the periphery are associated with a spectrum of neurobiological disorders, such as depression and anxiety. The measurement of specific imbalances may be a very effective neurobiological tool in guiding targeted intervention, aimed at addressing the individual excess or deficiency in question.
Clinical Validity of Urinary Neurotransmitter Assessment
The importance of effectively assessing and treating mood disorders cannot be overstated. Objectivity is a key element to the therapeutic approach to mood disorders. Currently, the standard of care dictates a trial and error pharmaceutical approach is taken with each patient based on both self and clinician assessments. However, without information yielded from objective clinical testing, the selection of the most effective treatment for each particular patient with a mood disorder continues to be a challenge. While this may prove effective for some patients, the potential for harm during those interim treatment failures is a real concern for clinicians and patients alike. Urinary neurotransmitter testing is performed with the goal that therapeutic interventions may be introduced to address, alleviate, and improve a patient’s well-being and has a breadth of data to support the efficacy of the test in clinical practice. Evaluation of neurotransmitter levels in urine provides valuable information about the heterogeneity of patient biochemistry, epigenetics, and how the body functions as a whole. Although the urine test is not a direct measure of brain neurotransmitter levels, it provides relevant information with respect to neurotransmitter regulation in the brain, which can be altered by treatment. The levels in urine often parallel levels in the central nervous system and the test may therefore assist in the selection of patients with mood issues who might respond to specific pharmaceutical or over-the-counter treatment interventions. In other words, the test provides a means to glean a functional systemic perspective regarding each neurotransmitter in the periphery, which ultimately operates under the control of the brain. How do neurotransmitters end up in urine? Some neurotransmitters are produced in the brain and transported across the blood-brain barrier into blood, and others are produced in the periphery (e.g., norepinephrine and epinephrine). Nephrons, the functional units of the kidney, filter circulating neurotransmitters or their precursors from the blood into the urine. For some neurotransmitters, urinary measurements correlate with levels in the central nervous system (e.g., glutamate, PEA), and for others, what ends up in urine is only reflective of peripheral biosynthesis (e. g., serotonin, GABA, dopamine, norepinephrine, epinephrine). Regardless of production origin, neurotransmitter excretion reflects the overall systemic neurotransmitter tone, dysregulation of which may contribute to disease states. The ability to identify abnormality across specific areas of the catecholamine and PEA, GABA/ glutamate, serotonin, histamine, and glycine pathways allows healthcare providers to develop a tailored treatment plan to the specific areas associated with imbalance.
Dried Urine – A Convenient Testing Option
The nature of urine collection is non-invasive and preferable over the traditional invasive collection approaches such as measurement of cerebrospinal fluid. Even with liquid urine collection, the patient experiences the enormous hassle of collecting all urine voids over a 24-hour period into a large jug. To circumvent this inconvenience some labs have settled for collecting only the 2nd void, limiting neurotransmitter results to a single morning time point snapshot. ZRT Laboratory offers an alternative to the liquid urine collection method by offering a simple and convenient collection of four separate urine samples at specific time points throughout the day – 1st morning, 2nd morning (approximately 2 hours after the first collection), early evening, and bedtime. Urine is collected onto filter strips by urinating directly on the strip, or by dipping the filter card in a cup containing the collected urine. The urine cards are then allowed to dry overnight and sent to ZRT for testing. The convenience of the collection method warrants patient compliance and ease of incorporation into clinical practice.
- The neurotransmitter test assumes proper kidney function. Neurotransmitter levels are reported in µg/g creatinine, where creatinine is measured from the same sample. This test should not be used in individuals with compromised renal function.
- The sample can become very dilute due to increased fluid consumption during the day. Therefore, on the day of testing, individuals should restrict their liquid intake to normal consumption.
- On the day of testing, individuals are advised to refrain from consuming alcohol, nicotine, bananas, pineapple, and walnuts as they may interfere with testing.