Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — HPA Axis Dysfunction

Neurotransmitter testing is one of the most powerful functional assessment tools available — but it requires a nuanced approach to interpretation. In this clinical overview, Dr. Kate Placzek of ZRT Laboratory outlines the key fundamentals every practitioner needs before reading a neurotransmitter report: from understanding patterns over numbers and treatment sequencing, to the clinical significance of low serotonin on SSRIs, GABA’s peripheral mechanisms, and when to run a diurnal catecholamine assessment.

When a patient with PCOS or weight issues is told “your blood sugar is normal,” the story is far from over. In this clinical article, Dr. Alison McAllister of ZRT Laboratory explains why insulin — not glucose — is the primary driver of PCOS symptoms, weight gain, testosterone and DHEAS excess, and cortisol dysfunction. Understanding the progression from insulin resistance to hyperinsulinemia to type 2 diabetes is essential for identifying and treating PCOS at the earliest possible stage.

A growing body of research suggests that mitochondrial dysfunction may lie at the root of many treatment-resistant mental health conditions — including depression, anxiety, bipolar disorder, OCD and even dementia. In this clinical overview, Dr. Peter Bongiorno explains why neurons are particularly vulnerable to mitochondrial damage, how stress, heavy metals and hormonal imbalances compound the problem, and what a comprehensive 5-step repair plan looks like in practice.

Obesity is not simply a matter of calories in versus calories out. Chronic stress triggers a cascade of hormonal changes — elevated cortisol, depleted DHEA, disrupted leptin signalling and imbalanced sex hormones — that actively drive visceral fat storage and metabolic dysfunction. This article explains the biochemistry of stress-related weight gain and why understanding your hormone levels is key to breaking the cycle.

An estimated 80% of adults will experience some level of adrenal fatigue in their lifetime — yet it remains one of the most under-diagnosed conditions in modern medicine. When the adrenal glands are chronically overtaxed, cortisol output drops, leaving the body unable to manage stress, stabilise blood sugar or mount immune defences. This article explores the symptoms, causes and what you can do to identify and address adrenal fatigue through targeted hormone testing.