Advanced Neurotransmitter & Hormone Test I | 49 Markers

Test ID: SU-841 | Sample Type: Dried Urine + Saliva | Technology: Advanced LCMS analysis with specialist laboratory interpretation included | Laboratory: ZRT Laboratory (CLIA-certified) | Test Result: 3–5 working days after the laboratory receives your samples | Suitable For: Adults and Children | Collect Sample At Home: No Clinic Visit Required

SU-841 combines seven saliva hormone measurements with the Advanced urinary neurotransmitter profile and timed urinary cortisol, cortisone and melatonin-metabolite measurements. The combined report provides laboratory information to review with your practitioner alongside your symptoms, medicines and hormone treatments.

The total comprises seven saliva hormone measurements, 26 Advanced urinary entries including creatinine, 12 timed cortisol/cortisone/MT6s measurements and four additional creatinine measurements. These are 49 measurements, not 49 different substances. Creatinine is reported five times across the combined profile; this does not mean five urine collections.

The timed urinary cortisol and cortisone results provide daily profiles, while 6-Sulfatoxymelatonin (MT6s) provides information about urinary melatonin metabolism. MT6s is a melatonin metabolite, not a direct melatonin measurement. The saliva panel includes one morning cortisol measurement.

What Does This Test Measure?

LCMS Dried Urine Neurotransmitter Tests

LCMS Saliva Hormone Tests

Not Sure Which Test Is Right for You?

Email us at info@hormonelab.co.uk with your gender, age, symptoms, medications, and any current treatments. We will forward your enquiry to our doctors and respond within 24 hours with a suggestion.

Who Is This Test For?

This combined hormone, neurotransmitter and sleep–wake profile may be relevant if you experience:

• Difficulty falling asleep, staying asleep or waking refreshed
• Persistent tiredness, low energy or low motivation
• Feeling anxious, tense, overwhelmed or unable to switch off
• Low mood, irritability or mood changes
• Brain fog or difficulty concentrating
• Low libido or changes in sexual wellbeing
• Premenstrual mood changes or other PMS symptoms
• Irregular periods or changes in your menstrual cycle
• Hot flushes or night sweats
• Vaginal dryness
• Reduced strength, stamina or exercise recovery

Your results provide information about sex hormones, daily cortisol and melatonin patterns, and urinary neurotransmitter-related markers to guide a personalised review of your symptoms.

How Your Results Can Guide Your Next Steps

This profile brings together sex-hormone measurements, daily cortisol and melatonin patterns, and urinary neurotransmitter-related markers. Reviewed alongside your symptoms and health history, your results can help you and your healthcare professional decide which lifestyle changes, further investigations or treatments deserve attention.

Difficulty Sleeping or Waking Refreshed

The timed cortisol and melatonin measurements show your hormone pattern across the day and night. This provides useful information for reviewing your sleep schedule, morning daylight exposure, evening lighting, caffeine intake and exercise timing. Your clinician can use the findings to decide whether further sleep assessment would help.

Persistent Tiredness, Low Energy or Low Motivation

Cortisol and sex-hormone results add information relevant to energy and stamina, while the urinary panel measures substances involved in motivation and alertness. Your results can guide a discussion about regular meals, adequate nutrition, activity levels and recovery time—and whether further checks for causes such as anaemia or thyroid problems are appropriate.

Feeling Anxious, Tense or Unable to Switch Off

Your cortisol pattern provides information about daily stress-hormone activity. The neurotransmitter panel adds biochemical context from calming and stimulating pathways. Together, these findings can support a personalised review of caffeine, alcohol, sleep, exercise intensity and relaxation practices, alongside treatment for persistent anxiety where needed.

Low Mood, Irritability or Mood Changes

Sex hormones and neurotransmitter pathways both participate in mood regulation. Reviewing your results alongside when symptoms occur can help your clinician consider hormonal changes, sleep disruption, medication and nutritional factors. This can guide discussions about dietary support, physical activity, psychological support or further treatment.

Brain Fog or Difficulty Concentrating

The profile provides information from hormone and neurotransmitter-related pathways involved in attention and alertness. Your results can help focus a review of sleep quality, nutrition, stress and hormonal changes, and guide further assessment if concentration difficulties continue.

Low Libido or Changes in Sexual Wellbeing

Testosterone, oestrogens and DHEA-S measurements provide hormone information relevant to sexual wellbeing. Your clinician can review these alongside medication, stress, sleep and symptoms to discuss suitable options, including lifestyle changes, further investigations or treatment.

Premenstrual Symptoms or Menstrual Changes

Oestrogen and progesterone results, interpreted with your cycle timing and a symptom diary, can support a more focused assessment of recurring mood changes or menstrual symptoms. They can help guide discussions about symptom management, nutrition and whether a gynaecological review would be useful.

Hot Flushes, Night Sweats or Vaginal Dryness

Sex-hormone measurements add information to an assessment of symptoms during perimenopause or menopause. Your results and symptom history can support a discussion about treatment options, including hormone therapy where appropriate, vaginal treatments and practical measures to improve comfort and sleep.

Reduced Strength, Stamina or Exercise Recovery

Testosterone, DHEA-S and cortisol measurements provide additional information for reviewing reduced physical performance. Your clinician can consider the findings alongside your training, protein and calorie intake, sleep and recovery, helping you plan appropriate exercise adjustments or further assessment.

Turn Your Results Into a Personalised Plan

The benefit is a more informed conversation about what to do next: which habits to adjust, whether nutritional support is appropriate, what else to investigate and which treatments to discuss. Agreeing clear goals with your healthcare professional also gives you a practical way to track changes in your symptoms over time.

Why Combine Hormones & Neurotransmitters?

Hormones and nervous-system signalling are involved in mood, sleep, energy and sexual wellbeing. The saliva panel provides selected reproductive and adrenal hormone measurements, while the urinary panel provides neurotransmitter-related measurements and timed hormone and melatonin-metabolite profiles. Reviewing both sets together provides broader laboratory information when fatigue, mood changes, low libido, PMS or poor sleep overlap.

Parent neurotransmitters are measured alongside related metabolites, including dopamine with DOPAC and HVA, serotonin with 5-HIAA, and histamine with N-methylhistamine. Reviewing related compounds together provides a broader biochemical picture than considering individual markers alone.

The Benefit of Adding Free Cortisol, Free Cortisone & Creatinine

Free cortisol, free cortisone and creatinine add timed urinary hormone measurements and urine-concentration information to the neurotransmitter profile.

Comprehensive Neuroendocrine Insight
The combined report brings saliva hormones, urinary neurotransmitter-related compounds and daily urinary hormone profiles together for practitioner review.

Stress Response Assessment
Timed free cortisol and free cortisone results provide daily urinary glucocorticoid profiles to discuss alongside your sleep, routine and stress concerns.

Mood & Cognitive Evaluation
Selected hormone and urinary neurotransmitter-related findings provide additional laboratory information when mood changes or concentration concerns occur together.

Adrenal Function Review
Your practitioner can review the cortisol and cortisone measurements alongside your symptoms, health history and any need for further assessment.

Sleep & Energy Regulation
Timed urinary cortisol, cortisone and MT6s results add information to review alongside a sleep diary and the times you feel tired or more alert.

Creatinine Normalisation
Creatinine helps account for differences in urine concentration when interpreting urinary results.

Personalised Treatment Planning
Discuss the report with your healthcare professional to consider appropriate further assessment and nutrition, lifestyle or wellbeing steps. Do not change prescribed treatment without their advice.

Key Features

Comprehensive Neurochemical Profile
Measures selected urinary neurotransmitters, amino acid precursors and related metabolites alongside saliva hormones and timed urinary profiles.

Objective Biomarker Measurement
Provides numerical laboratory results and reference ranges to review alongside your symptoms and health history.

Personalised Treatment Planning
Use the combined report to prepare focused questions for your practitioner about the findings and appropriate next steps.

Clinical Diagnostic Support
The laboratory findings provide additional information for a healthcare consultation. Your practitioner determines whether further clinical assessment is appropriate.

Targeted Therapeutic Direction
Specialist laboratory interpretation helps explain the measured results for discussion with your practitioner.

Treatment Monitoring
Where your practitioner recommends repeat testing, measured results can be compared while taking collection conditions, medicines and supplements into account.

Convenient At-Home Collection
Collect one morning saliva sample and four timed dried urine samples using the supplied materials. Follow the kit's collection, storage and return instructions.

Reliable Laboratory Analysis
LCMS laboratory analysis with specialist laboratory interpretation included.

Delivery: Free delivery in the UK.

Shipping: Customers are responsible for shipping their samples to the laboratory. A return envelope is supplied, but it is not prepaid.

No Additional Fee: The test kit includes a laboratory fee: no additional laboratory cost or tax.

Click to see >> Sample Saliva Test Result Report

Click to see >> Advanced Neurotransmitter Test Report

The test must be used within 12 months after the purchase date.

Test Result Report: You will receive your test result via email within 3–5 working days after the laboratory receives your samples. Your report includes numerical and graphical results, reference ranges and specialist PhD laboratory interpretation. This is laboratory commentary, not a medical-doctor consultation. Review the findings with your healthcare professional alongside your symptoms and treatment history.

The Test Kit Pack Includes

• Test Requisition Form including Symptom Checklist
• Requisition Form to complete, including personal and medical history
• Collection instructions
• Urine strips for collecting dried urine samples and tubes for collecting saliva samples
• Instructions on how to use the Collection Kit
• Return Envelope
• Shipping instructions

NEUROTRANSMITTERS PLAY A KEY ROLE

Neurotransmitters have many roles throughout the nervous system. The examples below describe general biological functions, not conclusions that can be drawn from this urinary test. Acetylcholine, endorphins and enkephalins are not included in this panel.

Regulation of Mood and Emotions
Serotonin, dopamine and norepinephrine are involved in nervous-system signalling related to mood, motivation and reward.

Control of Motor Functions
Acetylcholine, dopamine and GABA are involved in movement and muscle control.

Cognitive Function and Learning
Glutamate, acetylcholine and dopamine have roles in learning, attention and memory.

Regulation of Sleep and Wakefulness
Serotonin and norepinephrine have roles in sleep-wake signalling.

Modulation of Pain Perception
Endorphins and enkephalins are involved in pain signalling.

Autonomic Functions
Nervous-system signalling helps regulate heart rate, blood pressure, digestion and respiration.

Regulation of Appetite and Satiety
Serotonin and related signalling pathways are involved in appetite and satiety.

Saliva and Dried Urine Collection Instructions

Collect your samples at home using the materials provided in your SU-844 kit. This panel requires four saliva samples and four dried urine samples. Saliva and urine samples can be collected on separate days.

Before You Begin

Read the full instructions supplied with your kit. Record all current medications, supplements and hormone treatments on your Test Requisition Form.

• Three days before collection: Avoid anti-ageing or anti-wrinkle facial creams and biotin (vitamin B7), including hair and nail supplements.
• The day before and the day of testing: ZRT recommends avoiding bananas, pineapple, nuts, nut butters, alcohol, nicotine, protein powders and protein shakes.
• Before saliva collection: Do not eat, drink anything other than water, or brush your teeth before the first sample or during the two hours before subsequent samples.

Choosing Your Collection Day

Men, children and women who do not menstruate: Collect on any day of the month. If you use hormone treatments, also follow the guidance below.

Women with regular periods: For saliva hormone testing, choose your collection day according to your usual cycle length. Day 1 is the first day of menstrual flow, rather than spotting.

Women with irregular or infrequent periods: Collect on any non-bleeding day.

For dried urine collection: Avoid menstruation or any time blood could enter your urine sample. Urine collection does not require a specific menstrual-cycle day.

Saliva Collection Timing

Begin your morning saliva collection within 30 minutes of waking, using the large 10 ml tube. Use a small 5 ml tube for each later collection.

How to Collect Saliva

• Wash your hands with soap and water and dry them with a clean towel.
• Rinse your mouth with water, then wait five minutes.
• Allow saliva to pool in your mouth and transfer it into the tube. Fill the tube at least halfway, excluding bubbles. Collection usually takes 15–30 minutes.
• Screw the cap on securely.
• Write your name, collection date and time on the tube label, then return the tube to its bag.
• Repeat at the remaining collection times required for your panel.

If you make a collection mistake, rinse the tube with hot water without soap, shake out the remaining water and allow it to air-dry before restarting at the appropriate time.

Freeze saliva samples if they will not be shipped within 24 hours.

Dried Urine Collection Timing

Collect four urine samples:

Before the first urine collection, do not eat, drink anything other than water, or take vitamins or supplements. Follow your healthcare provider’s advice about medication timing.

Limit fluid intake to no more than approximately 240 ml (8 oz) during the hour before each urine collection to avoid diluting your sample.

How to Collect Dried Urine

• Remove a collection card from its bag and write your name, collection date and time on it.
• Open the cover and fold it away from the filter paper. Avoid touching the filter paper.
• Fully saturate the paper by urinating directly onto it, or collect urine in a clean cup and dip the paper up to the top black dashed line.
• Hang or tape the card somewhere secure, ensuring the wet paper does not touch anything.
• Allow it to dry completely for at least six hours. Once dry, refold the card, place it in its bag and seal it. Do not leave samples outside the bag for longer than 24 hours.
• Repeat for each collection time.

Missed a urine collection? Collect that sample at the same time the following day. Record the actual date and time on the card and Test Requisition Form.

If You Use Hormone Treatments

Record all hormone treatments on your form. Do not stop prescribed treatment without your healthcare provider’s advice.

• Topical or oral hormones: Follow the kit’s timing instructions. The previous evening’s dose should generally be at least 12 hours before morning collection; oral progesterone may be taken at bedtime.
• Prevent contamination: Use gloves or an applicator for topical hormones for at least two days before collection. Avoid applying hormones to your face, lips or neck. Change sheets, pillowcases and towels the night before collection and avoid surfaces that may contain hormone residue.
• Patches, vaginal rings, pellets or injections: Follow the laboratory’s guidance to collect halfway between doses.
• Troches or sublingual hormones: The laboratory does not recommend saliva testing with these therapies. Discuss blood spot testing with your healthcare provider.
• 7-Keto DHEA: The laboratory advises avoiding it for three days before collection. This does not apply to regular DHEA.
• Steroid medicines: Ask your healthcare provider about appropriate collection timing.
• On the urine collection day: Take your morning hormone dose after the first urine sample and wash your hands thoroughly. Collect the bedtime sample before nighttime hormones. The laboratory advises avoiding vaginal hormone use until after the final urine sample; discuss any timing adjustment with your healthcare provider.

Returning Your Samples

Complete the Test Requisition Form in full. Place all labelled samples, the completed form and any additional paperwork into the test kit box. Ensure urine cards are completely dry and sealed, then return the kit according to the supplied return instructions.

A return envelope is provided. It is not prepaid; customers are responsible for return postage to the laboratory.

Important: Urine samples that are wet, unsealed, excessively diluted or more than 30 days old will not be processed, replaced or refunded.

Read the full laboratory collection instructions.