Advanced Neurotransmitter & Toxic Elements Test | Specialist Interpretation Included

Test ID: U-325 + U-327 | Sample Type: Dried Urine | Technology: LC-MS + ICP-MS | Results: 3–5 Working Days | Laboratory: ZRT Laboratory (CLIA-certified)

Neurotransmitters and Toxic Elements — Measured Together in One Dried Urine Test

This dual-panel test combines a full 26-marker LC-MS neurotransmitter profile with an 8-element ICP-MS toxic and essential elements analysis — all from a single at-home dried urine collection.

Toxic heavy metals including mercury, arsenic, and cadmium are known to directly interfere with neurotransmitter synthesis, receptor function, and neurological health. This test is designed for anyone who wants to understand whether environmental toxin exposure may be contributing to mood, cognitive, or neurological symptoms alongside their neurochemical profile.

What This Test Measures (34 Markers)

Dried Urine — 26 Neurotransmitters & Metabolites (LC-MS)

• Tryptophan (Trp), Serotonin (5-HT), 5-HIAA
• GABA, Glycine (Gly), Taurine (Tau), Glutamate (Glu), Glutamine (Gln)
• Histidine (His), Histamine (HIST), N-Methylhistamine (N-MeHist)
• Phenylethylamine (PEA), Tyrosine (Tyr), Tyramine (Tyra)
• Dopamine (DA), DOPAC, Homovanillic Acid (HVA)
• Norepinephrine (NE), Normetanephrine (NMN), Epinephrine (Epi), Vanillylmandelic Acid (VMA)
• Kynurenine (Kyn), Kynurenic Acid (KynAc), 3-Hydroxykynurenine (3OHKyn), Xanthurenic Acid (Xanth)
• Creatinine (Crtn)

Dried Urine — 8 Toxic & Essential Elements (ICP-MS)

• Iodine (I) — essential for thyroid hormone production; deficiency impairs metabolism, growth, and development
• Bromine (Br) — competes with iodine at thyroid receptor sites; excess bromine can disrupt thyroid hormone synthesis
• Selenium (Se) — essential for thyroid hormone metabolism and antioxidant defence; low levels impair thyroid function
• Arsenic (As) — toxic element found in food and water; chronic exposure disrupts thyroid hormone synthesis and neurological function
• Mercury (Hg) — highly toxic; accumulates from fish and dental amalgams; linked to thyroid dysfunction, cognitive impairment, and neurotoxicity
• Cadmium (Cd) — toxic heavy metal from industrial exposure and cigarette smoke; associated with thyroid disorders and kidney damage
• Lithium (Li) — naturally occurring element; affects thyroid hormone synthesis; relevant for those on lithium medication
• Creatinine (Crtn) — urine concentration marker used to correct all elemental results

Why Test Toxic Elements Alongside Neurotransmitters?

Heavy metals and toxic elements are well-established neurotoxins. Mercury, arsenic, and cadmium can:

• Disrupt dopamine, serotonin, and GABA synthesis and receptor function
• Impair thyroid hormone production — which in turn affects mood, energy, cognition, and metabolism
• Cause oxidative stress that damages neurons and neurotransmitter pathways
• Mimic or worsen symptoms of anxiety, depression, brain fog, fatigue, and ADHD

By measuring both neurotransmitters and toxic elements in the same test, this panel can help identify whether environmental toxin burden is a contributing factor to neurological and mood symptoms — something a neurotransmitter-only test would miss entirely.

Symptoms This Test Can Help Investigate

• Unexplained fatigue, brain fog, or poor concentration
• Anxiety, low mood, or mood instability
• ADHD symptoms, impulsivity, or hyperactivity
• Poor sleep or insomnia
• Suspected heavy metal or environmental toxin exposure
• Thyroid-related symptoms: weight changes, cold intolerance, hair loss, low energy
• Neurological symptoms without clear diagnosis
• Frequent fish consumption or history of dental amalgam fillings

Who Is This Test For?

This test is suitable for adults and children who want to:

• Assess whether toxic element exposure is contributing to neurological or mood symptoms
• Evaluate thyroid-relevant elements (iodine, selenium, bromine) alongside neurotransmitter balance
• Investigate the neurochemical drivers of unexplained fatigue, brain fog, anxiety, or cognitive decline
• Gain a comprehensive picture of both neurochemistry and toxic load in a single convenient test

How It Works

1. Order your kit — delivered directly to your door
2. Collect four dried urine samples throughout the day using the provided collection strips
3. Post your samples to the laboratory using the provided instructions
4. Receive your results by email within 3–5 working days of the lab receiving your samples

What You Receive With Your Results

• All 34 markers in clear graphics and easy-to-read values
• Full neurotransmitter pathway analysis including metabolites and precursors
• Toxic and essential elements panel with reference ranges
• A written interpretation by a Hormone Specialist PhD Doctor
• Guidance on what your results mean and recommended next steps
• Laboratory fee included — no hidden charges

View Sample Neurotransmitter Report  |  View Sample Toxic Elements Report

Why We Use ZRT Laboratory

All testing is performed by ZRT Laboratory — a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries. ZRT uses both LC-MS and ICP-MS technology to provide clinical-grade accuracy from at-home dried urine samples.

Hormone Lab UK (Testfield UK Ltd) is the official UK test provider for ZRT Laboratory.

Important Information

• Laboratory fee included — no hidden costs
• Customers are responsible for return shipping to the laboratory
• Test kit valid for 12 months from purchase date

Frequently Asked Questions

How do heavy metals affect neurotransmitters?
Mercury, arsenic, and cadmium are neurotoxins that can disrupt dopamine and serotonin synthesis, impair GABA receptor function, cause oxidative neuronal damage, and interfere with thyroid hormones — all of which affect mood, cognition, sleep, and energy. This test allows both the toxic burden and the resulting neurochemical impact to be assessed together.

Why is iodine included in the elements panel?
Iodine is essential for thyroid hormone production. Thyroid hormones regulate metabolism, mood, energy, and cognitive function. Iodine deficiency is common and often undetected. Bromine and selenium are also included because they directly influence thyroid hormone synthesis and metabolism.

Is this test suitable for children?
Yes. The dried urine collection is non-invasive and suitable for adults and children. This test may be particularly relevant for children with unexplained behavioural, cognitive, or developmental concerns where toxic element exposure is suspected.

Can this test diagnose heavy metal poisoning or neurological conditions?
No. This test cannot diagnose medical conditions. It provides biochemical data about urinary excretion of neurotransmitters and elements that may help guide further investigation with a qualified healthcare professional.

Does the price include the laboratory fee?
Yes. The full laboratory analysis fee for both panels is included. Return postage to the laboratory is not included.

How long is the kit valid for?
The kit must be used within 12 months of the purchase date.