Female Comprehensive Hormone Profile II | 14 Markers inc. Full Thyroid Panel

Test ID: B-243 | Sample Type: Dried Blood Spot | Test Method: LC-MS/MS | Results: 3–5 Working Days | Laboratory: ZRT Laboratory – CLIA Certified | Report: Specialist Doctor Comment Included | Suitable For: Women | Collect Sample At Home: No Clinic Visit Required

What This Test Measures

Sex Hormones & Adrenal Markers (8):

• Estrone (E1) — a post-menopausal oestrogen; elevated levels may indicate oestrogen dominance
• Estradiol (E2) — the primary reproductive oestrogen; key for cycle regulation, bone density, mood, and fertility
• Estriol (E3) — a weaker oestrogen that helps assess overall oestrogen balance, especially during perimenopause
• Progesterone (Pg) — essential for cycle balance, fertility, and counteracting oestrogen dominance
• Testosterone (T) — important for libido, energy, and muscle tone in women
• DHEA-S (DS) — an adrenal precursor hormone that declines with age; linked to vitality, mood, and immune function
• Cortisol (C) — the stress hormone; chronically elevated cortisol disrupts estradiol and progesterone balance
• SHBG — regulates how much estradiol and testosterone is biologically available to your tissues

Full Thyroid Panel (6):

• TSH — the primary screening marker for thyroid function
• Free T3 (fT3) — the active thyroid hormone; low fT3 is linked to fatigue, weight gain, and depression
• Free T4 (fT4) — the storage thyroid hormone converted to T3; key for assessing conversion issues
• Total T4 (TT4) — measures total thyroxine including protein-bound hormone
• TPO Antibodies (TPOab) — elevated levels indicate autoimmune thyroid disease (Hashimoto’s thyroiditis)
• Thyroglobulin (Tgbn) — a marker for thyroid tissue health and iodine-related dysfunction

Who Should Consider This Test?

• Complex or overlapping symptoms involving both hormones and thyroid
• Symptoms persisting despite normal standard GP blood tests
• Family history of thyroid disease or autoimmune conditions
• Perimenopause or menopause — thyroid disorders become significantly more common after 40
• Monitoring multiple hormone systems during or after HRT, thyroid medication, or other treatment
• Wanting the most comprehensive female hormone and thyroid baseline available at home

Are Complex, Overlapping Symptoms Leaving You Without Answers?

Thyroid and sex hormones are deeply interconnected — thyroid dysfunction can mimic or worsen hormonal imbalance, and vice versa. Many women are treated for one when the other is the root cause. If you recognise any of the following, this comprehensive 14-marker panel could finally give you the full picture:

• Persistent fatigue or exhaustion that doesn’t improve with rest
• Hot flushes, night sweats, or cold intolerance
• Irregular, heavy, or absent periods
• Mood swings, anxiety, depression, or tearfulness
• Brain fog, poor concentration, or increased forgetfulness
• Sleep disturbances or insomnia
• Unexplained weight gain or difficulty losing weight
• Low libido or vaginal dryness
• Hair loss, brittle nails, or thinning skin
• Bloating, acne, or oily skin
• Fertility concerns or irregular ovulation
• Heart palpitations or elevated cholesterol
• Swelling or puffiness around the eyes or face

Why Test Hormones and Thyroid Together?

A standard GP test typically only checks TSH for thyroid and oestrogen for hormones — missing the complex interplay between these systems. This panel measures 14 markers across sex hormones, adrenal function, and a full thyroid panel, giving you and your doctor a complete clinical picture and avoiding misdiagnosis.

How It Works

1. Order your kit — delivered to your door
2. Collect your sample at home — a simple finger-prick dried blood spot; no clinic or GP visit needed
3. Post your sample to ZRT Laboratory using the return instructions provided
4. Receive your results by email within 3–5 working days of the lab receiving your sample

What You Receive

• All 14 markers displayed clearly in graphics and numbers with sex-specific reference ranges
• Written interpretation by a Hormone Specialist PhD Doctor
• Guidance on what your results mean and what to do next
• Laboratory fee included — no hidden charges

Why We Use ZRT Laboratory

All testing is performed by ZRT Laboratory — a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries. ZRT is qualified for the CDC Hormone Standardization (HoSt) Program for testosterone and estradiol, and uses advanced LC-MS/MS technology for clinical-grade accuracy.

Frequently Asked Questions

What is the difference between Profile I and Profile II?
Profile I measures 8 sex hormones and adrenal markers. Profile II includes all 8 of those markers plus a full 6-marker thyroid panel — TSH, Free T3, Free T4, Total T4, TPO Antibodies, and Thyroglobulin — giving 14 markers in total. Profile II is recommended if you have any thyroid symptoms, a family history of thyroid disease, or suspect both systems may be involved.

What does a high TPO antibody result mean?
Elevated TPO antibodies indicate that your immune system is attacking your thyroid gland — the hallmark of Hashimoto’s thyroiditis, the most common cause of hypothyroidism in women. Many women with Hashimoto’s have normal TSH levels for years before diagnosis. This panel measures TPOab so that autoimmune thyroid disease can be identified early.

What is the difference between Free T3 and Free T4?
Free T4 is the inactive storage form of thyroid hormone, which your body converts into Free T3 — the active form that regulates metabolism, energy, mood, and temperature. Some people convert T4 to T3 poorly due to nutrient deficiencies, stress, or genetic factors. Measuring both allows detection of conversion problems missed by standard NHS TSH-only testing.

Is this test suitable during perimenopause or menopause?
Yes. Thyroid disorders become significantly more common after 40, and perimenopause involves dramatic shifts across all the sex hormones in this panel. Testing all 14 markers together provides the clearest picture of what is driving symptoms during this transitional phase.

Does the price include the laboratory fee?
Yes. The full laboratory analysis fee is included. You are only responsible for posting your sample to the laboratory.

How long is the kit valid for?
The kit must be used within 12 months of the purchase date.