Male Comprehensive Hormone Profile II | 14 Markers inc. Full Thyroid Panel

Test ID: B-243M | Sample Type: Dried Blood Spot | Test Method: LC-MS/MS | Results: 3–5 Working Days | Laboratory: ZRT Laboratory – CLIA Certified | Report: Specialist Doctor Comment Included | Suitable For: Men | Collect Sample At Home: No Clinic Visit Required

What This Test Measures

Sex Hormones & Adrenal Markers (8):

• Estrone (E1) — an oestrogen present in men; elevated levels are linked to fat gain and hormonal imbalance
• Estradiol (E2) — the primary oestrogen; men need balanced E2 for bone density and cardiovascular health, but excess causes low libido and gynaecomastia
• Estriol (E3) — a weaker oestrogen that helps assess overall oestrogen load in men
• Progesterone (Pg) — supports testosterone production and counteracts oestrogen dominance in men
• Testosterone (T) — the primary male sex hormone; critical for energy, muscle mass, libido, mood, and metabolic health
• DHEA-S (DS) — an adrenal precursor hormone that declines with age; linked to vitality, immune function, and testosterone production
• Cortisol (C) — the stress hormone; chronically elevated cortisol directly suppresses testosterone production
• SHBG — regulates how much testosterone is biologically available; high SHBG causes low-T symptoms even when total testosterone appears normal

Full Thyroid Panel (6):

• TSH — the primary screening marker for thyroid function
• Free T3 (fT3) — the active thyroid hormone; low fT3 is linked to fatigue, weight gain, and depression
• Free T4 (fT4) — the storage thyroid hormone converted to T3; key for assessing conversion issues
• Total T4 (TT4) — measures total thyroxine including protein-bound hormone
• TPO Antibodies (TPOab) — elevated levels indicate autoimmune thyroid disease (Hashimoto’s thyroiditis)
• Thyroglobulin (Tgbn) — a marker for thyroid tissue health and iodine-related dysfunction

Who Should Consider This Test?

• Complex or overlapping symptoms involving both hormones and thyroid
• Symptoms persisting despite normal standard GP blood tests
• Family history of thyroid disease or autoimmune conditions
• Suspected andropause, adrenal fatigue, or oestrogen dominance
• Monitoring multiple hormone systems during or after TRT, thyroid medication, or other treatment
• Wanting the most comprehensive male hormone and thyroid baseline available at home

Not Sure Which Test Is Right for You?

Email us at info@hormonelab.co.uk with your gender, age, symptoms, medications, and any current treatments. We will forward your enquiry to our doctors and respond within 24 hours.

Are Complex, Overlapping Symptoms Leaving You Without Answers?

Thyroid and sex hormones are deeply interconnected in men — thyroid dysfunction can suppress testosterone, raise SHBG, and worsen andropause symptoms. Many men are treated for low testosterone when the root cause is actually thyroid dysfunction. If you recognise any of the following, this comprehensive 14-marker panel could finally give you the full picture:

• Persistent fatigue or exhaustion that doesn’t improve with rest
• Low libido or erectile dysfunction
• Loss of muscle mass or increased body fat
• Mood swings, depression, or anxiety
• Brain fog, poor concentration, or increased forgetfulness
• Sleep disturbances or insomnia
• Hot flushes or night sweats (andropause symptoms)
• Unexplained weight gain or slow metabolism
• Hair thinning or loss
• Cold intolerance or low body temperature
• High cholesterol, elevated triglycerides, or heart palpitations
• Fertility concerns

Why Test Hormones and Thyroid Together?

A standard GP test typically only checks total testosterone and TSH separately — missing the complex interplay between these systems. This panel measures 14 markers across sex hormones, adrenal function, and a full thyroid panel, giving you and your doctor a complete clinical picture and avoiding misdiagnosis.

How It Works

1. Order your kit — delivered to your door
2. Collect your sample at home — a simple finger-prick dried blood spot; no clinic or GP visit needed
3. Post your sample to ZRT Laboratory using the return instructions provided
4. Receive your results by email within 3–5 working days of the lab receiving your sample

What You Receive

• All 14 markers displayed clearly in graphics and numbers with male-specific reference ranges
• Written interpretation by a Hormone Specialist PhD Doctor
• Guidance on what your results mean and what to do next
• Laboratory fee included — no hidden charges

Why We Use ZRT Laboratory

All testing is performed by ZRT Laboratory — a globally recognised, CLIA-certified diagnostic laboratory founded in 1998 by Dr. David Zava, PhD. ZRT has performed over 11 million tests and is trusted by healthcare professionals in 96+ countries. ZRT is qualified for the CDC Hormone Standardization (HoSt) Program for testosterone and estradiol, and uses advanced LC-MS/MS technology for clinical-grade accuracy.

Frequently Asked Questions

What is the difference between Profile I and Profile II?
Profile I measures 8 sex hormones and adrenal markers. Profile II includes all 8 of those markers plus a full 6-marker thyroid panel — TSH, Free T3, Free T4, Total T4, TPO Antibodies, and Thyroglobulin — giving 14 markers in total. Profile II is recommended if you have any thyroid symptoms, a family history of thyroid disease, or suspect both systems may be involved.

Can thyroid dysfunction cause low testosterone symptoms?
Yes — significantly so. Hypothyroidism raises SHBG, which reduces free testosterone availability. It also impairs testicular testosterone production and reduces LH sensitivity. Men with symptoms of low testosterone who have normal total testosterone levels should always have thyroid function assessed alongside SHBG.

What does a high TPO antibody result mean?
Elevated TPO antibodies indicate that your immune system is attacking your thyroid gland — the hallmark of Hashimoto’s thyroiditis. Many men with Hashimoto’s have normal TSH levels for years before diagnosis. This panel measures TPOab so that autoimmune thyroid disease can be identified early.

Does the price include the laboratory fee?
Yes. The full laboratory analysis fee is included. You are only responsible for posting your sample to the laboratory.

How long is the kit valid for?
The kit must be used within 12 months of the purchase date.