Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — #Neurotransmitters

Neurotransmitter testing is one of the most powerful functional assessment tools available — but it requires a nuanced approach to interpretation. In this clinical overview, Dr. Kate Placzek of ZRT Laboratory outlines the key fundamentals every practitioner needs before reading a neurotransmitter report: from understanding patterns over numbers and treatment sequencing, to the clinical significance of low serotonin on SSRIs, GABA’s peripheral mechanisms, and when to run a diurnal catecholamine assessment.

Hot flashes, mood instability, brain fog and memory changes during perimenopause are not “all in your head” — but they are very much in your brain. In this in-depth clinical article, Dr. Kate Placzek of ZRT Laboratory explains how declining estradiol disrupts brain glucose metabolism, neurotransmitter signalling and thermoregulation, why perimenopause represents a window of neurological vulnerability, and why the timing of hormone replacement therapy is critical to protecting long-term brain health.

When we talk about “stress,” or allostatic load, in terms of the perception of an event, we must realize that these “events” must first be translated into neurochemical signals before they trigger the HPA axis. Therefore, the sensitivity and outcome of translating these events (whether they are ongoing events, memories of past events, or stressful anticipation of unrealized events), is highly dependent upon signaling from other neurotransmitters. In fact, the signaling neurotransmitters that manage mood and affect often overlap with measures of HPA axis activation, and cannot be easily distinguished in some subjects. [1] While the detailed influence of neurotransmitters, such...

What if there was a safe, effective, inexpensive, and simple way to help treat one of the most common neurodevelopmental disorders of childhood? Health care professionals often overlook nutrients; yet imbalances in many minerals are frequently seen in medical disorders including ADHD. Fortunately, replenishing nutrients with an integrative treatment plan has proven to be an effective treatment for the symptoms of ADHD. In this two-part series, we will evaluate mineral deficiencies in zinc and magnesium, excess copper, and their relationship with neuropsychiatric symptoms. Minerals Essential for Health Minerals are inorganic substances essential for cell metabolism, neurotransmitter synthesis, growth, and development....

In perimenopause, falling estradiol doesn’t just trigger hot flashes — it disrupts serotonin production, driving mood swings, brain fog and sleepless nights. Discover the hormonal science behind “the change” and how testing can help.